Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
2250 records found | Showing page 1 of 90 (records 1-25) | Number of records to display | Find orthologs in
Organism | Name | Ortholog group | Product | Weight |
---|---|---|---|---|
M. tuberculosis | Rv0533c | OG5_129509 | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase I ... | 200 |
M. tuberculosis | Rv1305 | OG5_126818 | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodii ... | 185 |
M. tuberculosis | Rv1018c | OG5_131193 | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 185 |
M. tuberculosis | Rv1611 | OG5_129980 | Probable indole-3-glycerol phosphate synthase TrpC | 185 |
M. tuberculosis | Rv1850 | OG5_132452 | Urease alpha subunit UreC (urea amidohydrolase) | 185 |
M. tuberculosis | Rv1007c | OG5_127468 | Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) | 175 |
M. tuberculosis | Rv0983 | OG5_126815 | Probable serine protease PepD (serine proteinase) (MTB32B) | 175 |
M. tuberculosis | Rv2925c | OG5_127728 | Probable ribonuclease III Rnc (RNase III) | 175 |
M. tuberculosis | Rv0764c | OG5_129288 | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lano ... | 170 |
M. tuberculosis | Rv2763c | OG5_128410 | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 170 |
M. tuberculosis | Rv1848 | OG5_139588 | Urease gamma subunit UreA (urea amidohydrolase) | 170 |
M. tuberculosis | Rv1654 | OG5_130618 | Probable acetylglutamate kinase ArgB | 165 |
M. tuberculosis | Rv2537c | OG5_132746 | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 165 |
M. tuberculosis | Rv2178c | OG5_130802 | 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phen ... | 165 |
M. tuberculosis | Rv2539c | OG5_130547 | Shikimate kinase AroK (SK) | 165 |
M. tuberculosis | Rv1094 | OG5_237738 | Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (s ... | 165 |
M. tuberculosis | Rv3607c | OG5_133572 | Probable dihydroneopterin aldolase FolB (DHNA) | 165 |
M. tuberculosis | Rv2391 | OG5_132911 | Ferredoxin-dependent sulfite reductase SirA | 165 |
M. tuberculosis | Rv2225 | OG5_129046 | 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB | 165 |
M. tuberculosis | Rv3602c | OG5_129569 | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activatin ... | 165 |
M. tuberculosis | Rv3465 | OG5_132926 | dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimer ... | 165 |
M. tuberculosis | Rv3280 | OG5_130273 | Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:ca ... | 160 |
M. tuberculosis | Rv2276 | No group | Cytochrome P450 121 Cyp121 | 160 |
M. tuberculosis | Rv3795 | OG5_166834 | Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylin ... | 160 |
M. tuberculosis | Rv3793 | OG5_166834 | Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylin ... | 160 |