Target list

Search results for query: Wes VV TB Prioritized Targets: Structure, Enzyme, <600AA, essential, curated, not in human

  • Score for genes in query #61 (TB E coli essentials): 20
  • Score for genes in query #60 (TB known essentials): 35
  • Score for genes in query #59 (TB with Modeled structures): 20
  • Score for genes in query #48 (TB curated): 50
  • Score for genes in query #58 (TB w/ solved structures): 30
  • Score for genes in query #63 (TB not in human): 10
  • Score for genes in query #52 (TB enzymes (any EC #)): 35
  • Score for genes in query #62 (TB essential in any species): 10
  • Score for genes in query #54 (TB < 600 AA): 25

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2250 records found | Showing page 1 of 90 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0533c   OG5_129509   3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase I ... 200
M. tuberculosis   Rv1305   OG5_126818   Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodii ... 185
M. tuberculosis   Rv1018c   OG5_131193   Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 185
M. tuberculosis   Rv1611   OG5_129980   Probable indole-3-glycerol phosphate synthase TrpC 185
M. tuberculosis   Rv1850   OG5_132452   Urease alpha subunit UreC (urea amidohydrolase) 185
M. tuberculosis   Rv1007c   OG5_127468   Methionyl-tRNA synthetase MetS (MetRS) (methionine--tRNA ligase) 175
M. tuberculosis   Rv0983   OG5_126815   Probable serine protease PepD (serine proteinase) (MTB32B) 175
M. tuberculosis   Rv2925c   OG5_127728   Probable ribonuclease III Rnc (RNase III) 175
M. tuberculosis   Rv0764c   OG5_129288   Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lano ... 170
M. tuberculosis   Rv2763c   OG5_128410   Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 170
M. tuberculosis   Rv1848   OG5_139588   Urease gamma subunit UreA (urea amidohydrolase) 170
M. tuberculosis   Rv1654   OG5_130618   Probable acetylglutamate kinase ArgB 165
M. tuberculosis   Rv2537c   OG5_132746   3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 165
M. tuberculosis   Rv2178c   OG5_130802   3-deoxy-D-arabino-heptulosonate 7-phosphate synthase AroG (DAHP synthetase, phen ... 165
M. tuberculosis   Rv2539c   OG5_130547   Shikimate kinase AroK (SK) 165
M. tuberculosis   Rv1094   OG5_237738   Possible acyl-[acyl-carrier protein] desaturase DesA2 (acyl-[ACP] desaturase) (s ... 165
M. tuberculosis   Rv3607c   OG5_133572   Probable dihydroneopterin aldolase FolB (DHNA) 165
M. tuberculosis   Rv2391   OG5_132911   Ferredoxin-dependent sulfite reductase SirA 165
M. tuberculosis   Rv2225   OG5_129046   3-methyl-2-oxobutanoate hydroxymethyltransferase PanB 165
M. tuberculosis   Rv3602c   OG5_129569   Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activatin ... 165
M. tuberculosis   Rv3465   OG5_132926   dTDP-4-dehydrorhamnose 3,5-epimerase RmlC (dTDP-4-keto-6-deoxyglucose 3,5-epimer ... 165
M. tuberculosis   Rv3280   OG5_130273   Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:ca ... 160
M. tuberculosis   Rv2276     No group Cytochrome P450 121 Cyp121 160
M. tuberculosis   Rv3795   OG5_166834   Integral membrane indolylacetylinositol arabinosyltransferase EmbB (arabinosylin ... 160
M. tuberculosis   Rv3793   OG5_166834   Integral membrane indolylacetylinositol arabinosyltransferase EmbC (arabinosylin ... 160