Target list

Search results for query: Wes VV TB Prioritized Targets: Structure, Enzyme, <600AA, essential, curated, not in human

  • Score for genes in query #60 (TB known essentials): 35
  • Score for genes in query #61 (TB E coli essentials): 20
  • Score for genes in query #52 (TB enzymes (any EC #)): 35
  • Score for genes in query #54 (TB < 600 AA): 25
  • Score for genes in query #62 (TB essential in any species): 10
  • Score for genes in query #59 (TB with Modeled structures): 20
  • Score for genes in query #48 (TB curated): 50
  • Score for genes in query #58 (TB w/ solved structures): 30
  • Score for genes in query #63 (TB not in human): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2250 records found | Showing page 2 of 90 (records 26-50) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0005   OG5_128755   DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... 160
M. tuberculosis   Rv1266c   OG5_142551   Probable transmembrane serine/threonine-protein kinase H PknH (protein kinase H) ... 160
M. tuberculosis   Rv0682   OG5_127680   30S ribosomal protein S12 RpsL 160
M. tuberculosis   Rv3708c   OG5_128664   Aspartate-semialdehyde dehydrogenase Asd (ASA dehydrogenase) (ASADH) (aspartic s ... 155
M. tuberculosis   Rv1306   OG5_134191   Probable ATP synthase B chain AtpF 155
M. tuberculosis   Rv0993   OG5_131936   UTP--glucose-1-phosphate uridylyltransferase GalU (UDP-glucose pyrophosphorylase ... 155
M. tuberculosis   Rv0006   OG5_129568   DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... 155
M. tuberculosis   Rv0524   OG5_129427   Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semial ... 155
M. tuberculosis   Rv3398c   OG5_130660   Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP syn ... 155
M. tuberculosis   Rv2210c   OG5_126731   Branched-chain amino acid transaminase IlvE 155
M. tuberculosis   Rv2995c   OG5_126870   Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3 ... 155
M. tuberculosis   Rv3441c   OG5_128112   Probable phospho-sugar mutase / MrsA protein homolog 155
M. tuberculosis   Rv2157c   OG5_132578   Probable UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-al ... 155
M. tuberculosis   Rv2156c   OG5_131597   Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 155
M. tuberculosis   Rv2421c   OG5_131883   Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophos ... 155
M. tuberculosis   Rv3257c   OG5_128112   Probable phosphomannomutase PmmA (PMM) (phosphomannose mutase) 155
M. tuberculosis   Rv2883c   OG5_130032   Probable uridylate kinase PyrH (UK) (uridine monophosphate kinase) (UMP kinase) 155
M. tuberculosis   Rv1415   OG5_127275   Probable riboflavin biosynthesis protein RibA2 : GTP cyclohydrolase II + 3,4-dih ... 155
M. tuberculosis   Rv3457c   OG5_130460   Probable DNA-directed RNA polymerase (alpha chain) RpoA (transcriptase alpha cha ... 155
M. tuberculosis   Rv0415   OG5_144261   Possible thiamine biosynthesis oxidoreductase ThiO 155
M. tuberculosis   Rv0467   OG5_129572   Isocitrate lyase Icl (isocitrase) (isocitratase) 150
M. tuberculosis   Rv1484   OG5_130466   NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl ... 150
M. tuberculosis   Rv2965c   OG5_132912   Probable phosphopantetheine adenylyltransferase KdtB (pantetheine- phosphate ade ... 150
M. tuberculosis   Rv2841c   OG5_131885   Probable N utilization substance protein A NusA 150
M. tuberculosis   Rv2533c   OG5_132731   N utilization substance protein NusB (NusB protein) 150