Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.
1043 records found | Showing page 1 of 42 (records 1-25) | Number of records to display | Find orthologs in
| Organism | Name | Ortholog group | Product |
|---|---|---|---|
| M. tuberculosis | Rv0001 | OG5_132291 | Chromosomal replication initiator protein DnaA |
| M. tuberculosis | Rv0002 | OG5_132148 | DNA polymerase III (beta chain) DnaN (DNA nucleotidyltransferase) |
| M. tuberculosis | Rv0005 | OG5_128755 | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... |
| M. tuberculosis | Rv0006 | OG5_129568 | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisome ... |
| M. tuberculosis | Rv0009 | OG5_128211 | Probable iron-regulated peptidyl-prolyl cis-trans isomerase A PpiA (PPIase A) (r ... |
| M. tuberculosis | Rv0014c | OG5_146588 | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) |
| M. tuberculosis | Rv0015c | OG5_155711 | Transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A) |
| M. tuberculosis | Rv0016c | OG5_133524 | Probable penicillin-binding protein PbpA |
| M. tuberculosis | Rv0032 | OG5_126783 | Possible 8-amino-7-oxononanoate synthase BioF2 (AONS) (8-amino-7-ketopelargonate ... |
| M. tuberculosis | Rv0038 | OG5_131289 | Conserved protein |
| M. tuberculosis | Rv0041 | OG5_127675 | Probable leucyl-tRNA synthetase LeuS (leucine--tRNA ligase) (LEURS) |
| M. tuberculosis | Rv0045c | OG5_128173 | Possible hydrolase |
| M. tuberculosis | Rv0053 | OG5_131749 | 30S ribosomal protein S6 RpsF |
| M. tuberculosis | Rv0054 | OG5_127389 | Single-strand binding protein Ssb (helix-destabilizing protein) |
| M. tuberculosis | Rv0055 | OG5_128626 | 30S ribosomal protein S18-1 RpsR1 |
| M. tuberculosis | Rv0058 | OG5_131890 | Probable replicative DNA helicase DnaB |
| M. tuberculosis | Rv0060 | OG5_133608 | Conserved hypothetical protein |
| M. tuberculosis | Rv0066c | OG5_126691 | Probable isocitrate dehydrogenase [NADP] Icd2 (oxalosuccinate decarboxylase) (ID ... |
| M. tuberculosis | Rv0068 | OG5_126621 | Probable oxidoreductase |
| M. tuberculosis | Rv0070c | OG5_126679 | Serine hydroxymethyltransferase GlyA2 (serine methylase 2) (SHMT 2) |
| M. tuberculosis | Rv0073 | OG5_126906 | Probable glutamine-transport ATP-binding protein ABC transporter |
| M. tuberculosis | Rv0085 | OG5_147565 | Possible hydrogenase HycP |
| M. tuberculosis | Rv0086 | OG5_134238 | Possible hydrogenase HycQ |
| M. tuberculosis | Rv0092 | OG5_126855 | Cation transporter P-type ATPase a CtpA |
| M. tuberculosis | Rv0102 | OG5_156768 | Probable conserved integral membrane protein |