Target list

Search results for query: Reweightable Leish rankings (12 criteria)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #344 (Leish essential): 40
  • Score for genes in query #346 (Leish druggability > 0.6): 35
  • Score for genes in query #348 (Leish PubMed publications): 35
  • Score for genes in query #337 (Leish enzymes): 100
  • Score for genes in query #339 (Leish no transmembrane domains): 20
  • Score for genes in query #343 (Leish not in humans): 25
  • Score for genes in query #347 (Leish compound desirability > 0.3): 35
  • Score for genes in query #338 (Leish < 100 kDa): 20
  • Score for genes in query #340 (Leish PDB structure): 50
  • Score for genes in query #342 (Leish present in all TriTryps): 25
  • Score for genes in query #341 (Leish structural model (ModBase)): 30
  • Score for genes in query #345 (Leish genetic validation): 50

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

8205 records found | Showing page 1 of 329 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
L. major   LmjF.29.0820   OG5_127800   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin ... 445
L. major   LmjF.36.0550   OG5_126712   cell division related protein kinase 2,cdc2-related kinase 415
L. major   LmjF.23.0050   OG5_126792   cyclophilin 11, putative 415
L. major   LmjF.05.0350   OG5_126785   trypanothione reductase 415
L. major   LmjF.06.0120   OG5_127452   cyclophilin 2 415
L. major   LmjF.25.0910   OG5_126792   cyclophilin a 415
L. major   LmjF.18.0270   OG5_126888   glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 415
L. major   LmjF.06.0860   OG5_127385   dihydrofolate reductase-thymidylate synthase 415
L. major   LmjF.36.1960   OG5_127648   phosphomannomutase, putative 395
L. major   LmjF.24.0850   OG5_127002   triosephosphate isomerase 380
L. major   LmjF.13.0390   OG5_126605   alpha tubulin 380
L. major   LmjF.21.1080   OG5_126712   cell division protein kinase 2,cdc2-related kinase 380
L. major   LmjF.19.1440   OG5_126781   mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 380
L. major   LmjF.30.2970   OG5_126628   glyceraldehyde 3-phosphate dehydrogenase, glycosomal 380
L. major   LmjF.08.1080   OG5_126607   cathepsin L-like protease 375
L. major   LmjF.08.1060   OG5_126607   cathepsin L-like protease 375
L. major   LmjF.08.1030   OG5_126607   cathepsin L-like protease 375
L. major   LmjF.34.1260   OG5_127218   mitochondrial DNA polymerase I protein A, putative 365
L. major   LmjF.22.1360   OG5_127590   farnesyl pyrophosphate synthase 365
L. major   LmjF.31.2940   OG5_129470   squalene synthase, putative 365
L. major   LmjF.28.2430   OG5_127061   vacuolar ATP synthase subunit b, putative 365
L. major   LmjF.33.1630   OG5_126792   cyclophilin 4, putative 365
L. major   LmjF.19.0550   OG5_126721   methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 365
L. major   LmjF.32.1580   OG5_127555   phosphomannose isomerase 365
L. major   LmjF.30.0880   OG5_128398   adenosine kinase, putative 365