Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #13 ( expressed in egg stage (ESTs)): 3
  • Score for genes in query #8 (any essentiality evidence): 3
  • Score for genes in query #1 (Orthologs of D. melanogaster genes with mutant phenotype lethal): 10
  • Score for genes in query #3 (Embryonic Lethal/Arrest in C. elegans): 10
  • Score for genes in query #4 (Growth Defect in C. elegans): 3
  • Score for genes in query #6 (Morphology Defect in C. elegans): 3
  • Score for genes in query #10 (structural model available): 10
  • Score for genes in query #9 (in human): -20
  • Score for genes in query #2 (Orthologs of D. melanogaster genes with mutant phenotype "neurophysiological defect"): 10
  • Score for genes in query #5 (Larval/Adult Lethal/Arrest in C. elegans): 10
  • Score for genes in query #14 ( expressed in schistosomula stage (ESTs)): 3
  • Score for genes in query #16 (Caffrey et al 's TOP 18): 0
  • Score for genes in query #12 (expressed in adult worm (ESTs)): 3
  • Score for genes in query #15 (expressed in any relevant stage (ESTs)): 10
  • Score for genes in query #17 (Caffrey et al 's TOP 35): 0
  • Score for genes in query #7 (Sterility in C. elegans): 3
  • Score for genes in query #11 (druggable genes inferred by sequence simiarity): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

10633 records found | Showing page 1 of 426 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
S. mansoni   Smp_025010   OG5_126846   casein kinase II beta subunit 85
S. mansoni   Smp_059340.1   OG5_131088   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimula ... 81
S. mansoni   Smp_027880   OG5_127549   hypothetical protein 81
S. mansoni   Smp_040970.1   OG5_126705   vacuolar proton atpases 81
S. mansoni   Smp_059340.2   OG5_131088   Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimula ... 81
S. mansoni   Smp_136710.1   OG5_126674   calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pum ... 75
S. mansoni   Smp_007260.1   OG5_126674   ATPase 75
S. mansoni   Smp_129050   OG5_126660   dynamin 75
S. mansoni   Smp_136710.2   OG5_126674   calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pum ... 75
S. mansoni   Smp_007260.2   OG5_126674   ATPase 75
S. mansoni   Smp_142050   OG5_126781   serine/threonine protein kinase 72
S. mansoni   Smp_044920   OG5_126660   dynamin 72
S. mansoni   Smp_040570.1   OG5_126724   rab5 72
S. mansoni   Smp_040570.2   OG5_126724   rab5 72
S. mansoni   Smp_027920   OG5_126605   tubulin subunit alpha 71
S. mansoni   Smp_090120.2   OG5_126605   alpha tubulin 71
S. mansoni   Smp_040970.3   OG5_126705   vacuolar proton atpases 71
S. mansoni   Smp_090120.1   OG5_126605   alpha tubulin 71
S. mansoni   Smp_015020   OG5_127003   Na+/K+ transporting ATPase subunit alpha 69
S. mansoni   Smp_161920   OG5_126595   actin 68
S. mansoni   Smp_059790.1   OG5_126720   transketolase 68
S. mansoni   Smp_016780   OG5_126605   tubulin subunit alpha 68
S. mansoni   Smp_034490   OG5_127762   proteasome catalytic subunit 1 (T01 family) 68
S. mansoni   Smp_060420.5   OG5_127875   suppressor of actin (sac) 68
S. mansoni   Smp_151140   OG5_246280   serine/threonine protein kinase 68

Showing page 1 (records 1-25) of 426