Target list

Search results for query: Weighted ranking of Pfa targets for PLOS-NTD

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #81 (Mtb no TM domain (now searched on pfa)): 20
  • Score for genes in query #90 (Mtb all proteins (now searched on pfa)): 1
  • Score for genes in query #80 (Mtb mwt <100kDa (now searched on pfa)): 20
  • Score for genes in query #82 (Mtb PDB (now searched on pfa)): 50
  • Score for genes in query #87 (Mtb dindex >=0.6 (now searched on pfa)): 35
  • Score for genes in query #88 (Mtb Compd desirability >0.3 (now searched on pfa)): 35
  • Score for genes in query #86 (Mtb any essentiality evidence (now searched on pfa)): 50
  • Score for genes in query #85 (Mtb any genetic validation (now searched on pfa)): 50
  • Score for genes in query #84 (Mtb not in humans (now searched on pfa)): 25
  • Score for genes in query #89 (Mtb assayable (now searched on pfa)): 35
  • Score for genes in query #83 (Mtb modbase (now searched on pfa)): 30
  • Score for genes in query #78 (Mtb enz (EC + func. Categ.) (now searched on pfa)): 100
  • Score for genes in query #93 (Pfa in Pvi): 25
  • Score for genes in query #79 (Mtb Pubmed (now searched on pfa)): 35

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.


4804 records found | Showing page 1 of 193 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_0417200   OG5_127385   bifunctional dihydrofolate reductase-thymidylate synthase 486
P. falciparum   PF3D7_0615100   OG5_130466   enoyl-acyl carrier reductase 461
P. falciparum   PF3D7_1439900   OG5_127002   triosephosphate isomerase 451
P. falciparum   PF3D7_1029600   OG5_127245   adenosine deaminase 436
P. falciparum   PF3D7_1127100   OG5_126992   deoxyuridine 5'-triphosphate nucleotidohydrolase 436
P. falciparum   PF3D7_1419800   OG5_126785   glutathione reductase 436
P. falciparum   PF3D7_0322000   OG5_126792   peptidyl-prolyl cis-trans isomerase 436
P. falciparum   PF3D7_0520900   OG5_127233   adenosylhomocysteinase 436
P. falciparum   PF3D7_0922500   OG5_126776   phosphoglycerate kinase 436
P. falciparum   PF3D7_0420200   OG5_130884   holo-[acyl-carrier-protein] synthase, putative 426
P. falciparum   PF3D7_0623000   OG5_128304   chorismate synthase 426
P. falciparum   PF3D7_1405600   OG5_126823   ribonucleoside-diphosphate reductase small chain, putative 416
P. falciparum   PF3D7_1444800   OG5_127143   fructose-bisphosphate aldolase 416
P. falciparum   PF3D7_0603300   OG5_127289   dihydroorotate dehydrogenase 416
P. falciparum   PF3D7_1467300   OG5_130462   1-deoxy-D-xylulose 5-phosphate reductoisomerase 411
P. falciparum   PF3D7_0211400   OG5_129509   beta-ketoacyl-ACP synthase III 411
P. falciparum   PF3D7_1012400   OG5_127374   hypoxanthine-guanine phosphoribosyltransferase 401
P. falciparum   PF3D7_1354500   OG5_127011   adenylosuccinate synthetase 401
P. falciparum   PF3D7_1414400   OG5_126821   serine/threonine protein phosphatase PP1 401
P. falciparum   PF3D7_1416500   OG5_126857   NADP-specific glutamate dehydrogenase 401
P. falciparum   PF3D7_1247400   OG5_126727   peptidyl-prolyl cis-trans isomerase FKBP35 401
P. falciparum   PF3D7_0810800   OG5_128803   hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase 391
P. falciparum   PF3D7_1015300   OG5_126721   methionine aminopeptidase 1b, putative 386
P. falciparum   PF3D7_1115600   OG5_127452   peptidyl-prolyl cis-trans isomerase 386
P. falciparum   PF3D7_1434600   OG5_127231   methionine aminopeptidase 2 386