Target list

Search results for query: Union of (1, 2, 3, 4, 5, 6, 7, 9, 10, 11, 12)

You can Modify weights (moves query to your history allowing re-weight functionality) to match your needs

  • Score for genes in query #2 (tcruzi genes with 3D models): 30
  • Score for genes in query #3 (tcruzi genes absent in human/mouse): 50
  • Score for genes in query #4 (tcruzi genes with orthologs in T. brucei): 40
  • Score for genes in query #9 (amastigote expression >= 1 spectrum): 3
  • Score for genes in query #12 (trypomastigote expression >=2 spectra >=2 peptides): 4
  • Score for genes in query #5 (tcruzi genes essential in yeast): 50
  • Score for genes in query #7 (tcruzi genes with moderately good druggability prediction): 60
  • Score for genes in query #1 (tcruzi genes with 3D structures): 40
  • Score for genes in query #11 (trypomastigote expression >= 1 spectrum): 2
  • Score for genes in query #10 (amastigote expression >= 2 spectra / 2 peptides): 6
  • Score for genes in query #6 (tcruzi genes essential in bacteria): 50

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

18001 records found | Showing page 1 of 721 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
T. cruzi   TcCLB.509153.90   OG5_127385   dihydrofolate reductase-thymidylate synthase 270
T. cruzi   TcCLB.505763.19   OG5_127253   P-type H+-ATPase, putative 245
T. cruzi   TcCLB.506621.30   OG5_126823   ribonucleoside-diphosphate reductase small chain, putative 235
T. cruzi   TcCLB.509203.70   OG5_127113   DNA topoisomerase II, putative 230
T. cruzi   TcCLB.506529.340   OG5_216555   STE/STE11 serine/threonine-protein kinase, putative 230
T. cruzi   TcCLB.509167.190   OG5_164248   STE/STE11 serine/threonine-protein kinase, putative 230
T. cruzi   TcCLB.509167.100   OG5_126723   valyl-tRNA synthetase, putative 230
T. cruzi   TcCLB.508699.10   OG5_127113   DNA topoisomerase II, putative 230
T. cruzi   TcCLB.506649.20   OG5_127253   P-type H+-ATPase, putative 230
T. cruzi   TcCLB.507019.10   OG5_140087   STE/STE11 serine/threonine-protein kinase, putative 230
T. cruzi   TcCLB.506445.60   OG5_128755   mitochondrial DNA topoisomerase II, putative 230
T. cruzi   TcCLB.508277.370   OG5_128755   mitochondrial DNA topoisomerase II, putative 230
T. cruzi   TcCLB.510889.30   OG5_216555   STE/STE11 serine/threonine-protein kinase, putative 230
T. cruzi   TcCLB.509065.180   OG5_164248   protein kinase-like protein, putative 230
T. cruzi   TcCLB.508323.9   OG5_127590   farnesyl pyrophosphate synthase, putative 220
T. cruzi   TcCLB.508647.200   OG5_127002   triosephosphate isomerase, putative 212
T. cruzi   TcCLB.511555.80   OG5_126823   ribonucleoside-diphosphate reductase small chain, putative 200
T. cruzi   TcCLB.511287.49   OG5_126583   aldo-keto reductase 195
T. cruzi   TcCLB.508909.20   OG5_126887   GMP reductase 195
T. cruzi   TcCLB.509233.180   OG5_127099   ATP synthase subunit beta, mitochondrial, putative 195
T. cruzi   TcCLB.506519.130   OG5_126887   GMP reductase 195
T. cruzi   TcCLB.511823.70   OG5_127590   farnesyl pyrophosphate synthase 190
T. cruzi   TcCLB.510149.80   OG5_126568   ABC transporter, putative 189
T. cruzi   TcCLB.506989.30   OG5_126568   ABC transporter, putative 189
T. cruzi   TcCLB.510943.50   OG5_128522   delta-1-pyrroline-5-carboxylate dehydrogenase, putative 186

Showing page 1 (records 1-25) of 721