Target list

Search results for query: PLoS NTD Query 7 (P. falciparum apicoplast)

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  • Score for genes in query #248 (Pfa Dindex >=0.4): 20
  • Score for genes in query #246 (Pfa ortholog in taxon (Pvi)): 50
  • Score for genes in query #237 (Pfa all proteins): 1
  • Score for genes in query #243 (Pfa PDB structures): -100
  • Score for genes in query #238 (Pfa expression in any RBC stage (80-100%)): 25
  • Score for genes in query #241 (Pfa compound desirability >0.2): 10
  • Score for genes in query #247 (Pfa any genetic validation): -50
  • Score for genes in query #240 (Pfa uploaded weighted list for molecular weight): 0
  • Score for genes in query #249 (Pfa assayable): 20
  • Score for genes in query #242 (Pfa Pubmed): -20
  • Score for genes in query #244 (Pfa Modbase structure models): 10
  • Score for genes in query #245 (Pfa NOT in humans): 50
  • Score for genes in query #236 (Pfa any essentiality): 50
  • Score for genes in query #239 (Pfa uploaded weighted list for Isoelectric point): 0
  • Score for genes in query #235 (Pfa Enzymes (EC + functional category)): 100
  • Score for genes in query #251 (Curated list of nuclear encode apicoplast targeted gene from Stuart Ralph): 1000

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

4804 records found | Showing page 1 of 193 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
P. falciparum   PF3D7_1332600   OG5_129467   apurinic/apyrimidinic endonuclease Apn1, putative 1286
P. falciparum   PF3D7_0104400   OG5_130373   4-hydroxy-3-methylbut-2-enyl diphosphate reductase 1276
P. falciparum   PF3D7_1344800   OG5_128535   aspartate carbamoyltransferase 1261
P. falciparum   PF3D7_0716600   OG5_128800   cysteine desulfurase 1261
P. falciparum   PF3D7_1022800   OG5_130276   4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 1261
P. falciparum   PF3D7_0219500   OG5_128305   pseudouridine synthase, putative 1261
P. falciparum   PF3D7_1126000   OG5_126764   threonine--tRNA ligase 1256
P. falciparum   PF3D7_1406600   OG5_133657   ATP-dependent Clp protease regulatory subunit ClpC, putative 1256
P. falciparum   PF3D7_1005000   OG5_166421   methionine--tRNA ligase, putative 1241
P. falciparum   PF3D7_0925300   OG5_128299   proline--tRNA ligase, putative 1241
P. falciparum   PF3D7_1223300   OG5_129568   DNA gyrase subunit A 1241
P. falciparum   PF3D7_0731600   OG5_136613   acyl-CoA synthetase 1236
P. falciparum   PF3D7_1037100   OG5_144357   pyruvate kinase 2 1236
P. falciparum   PF3D7_1313400   OG5_156840   DEAD box helicase, putative 1236
P. falciparum   PF3D7_1367700   OG5_126799   alanine--tRNA ligase 1236
P. falciparum   PF3D7_0215300   OG5_136613   acyl-CoA synthetase 1236
P. falciparum   PF3D7_0504200   OG5_150571   ATP-dependent RNA helicase DDX27, putative 1236
P. falciparum   PF3D7_0509600   OG5_126756   asparagine--tRNA ligase 1236
P. falciparum   PF3D7_1216000   OG5_126677   serine--tRNA ligase, putative 1236
P. falciparum   PF3D7_1357200   OG5_127621   glutamate--tRNA ligase 1231
P. falciparum   PF3D7_1436800   OG5_134854   ATP-dependent Clp protease proteolytic subunit 1231
P. falciparum   PF3D7_1411400   OG5_127218   plastid replication-repair enzyme 1221
P. falciparum   PF3D7_0808200   OG5_133546   plasmepsin X 1216
P. falciparum   PF3D7_1116700   OG5_130494   dipeptidyl aminopeptidase 1 1216
P. falciparum   PF3D7_0504000   OG5_127048   cation transporting P-ATPase 1216

Showing page 1 (records 1-25) of 193