Target list

Search results for query: PLoS NTD query (L. major)

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  • Score for genes in query #531 (L. major genetic validation): 50
  • Score for genes in query #523 (L. major enzymes): 100
  • Score for genes in query #530 (L. major conserved in TriTryps): 25
  • Score for genes in query #529 (L. major not in humans): 25
  • Score for genes in query #534 (L. major assayability precedent): 35
  • Score for genes in query #527 (L. major PDB structures): 50
  • Score for genes in query #524 (L. major PubMed publications): 35
  • Score for genes in query #532 (L. major druggability >=0.6): 35
  • Score for genes in query #528 (L. major ModBase models): 30
  • Score for genes in query #526 (L. major no transmembrane domains): 20
  • Score for genes in query #522 (all L. major proteins): 1
  • Score for genes in query #525 (L. major MW < 100 kD): 20

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

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8243 records found | Showing page 1 of 330 (records 1-25) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
L. major   LmjF.29.0820   OG5_127800   cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin ... 381
L. major   LmjF.23.0270   OG5_133937   pteridine reductase 1 366
L. major   LmjF.36.1960   OG5_127648   phosphomannomutase, putative 366
L. major   LmjF.08.1080   OG5_126607   cathepsin L-like protease 351
L. major   LmjF.23.0050   OG5_126792   cyclophilin 11, putative 351
L. major   LmjF.05.0350   OG5_126785   trypanothione reductase 351
L. major   LmjF.06.0120   OG5_127452   cyclophilin 2 351
L. major   LmjF.25.0910   OG5_126792   cyclophilin a 351
L. major   LmjF.08.1060   OG5_126607   cathepsin L-like protease 351
L. major   LmjF.18.0270   OG5_126888   glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 351
L. major   LmjF.24.0850   OG5_127002   triosephosphate isomerase 351
L. major   LmjF.08.1030   OG5_126607   cathepsin L-like protease 351
L. major   LmjF.06.0860   OG5_127385   dihydrofolate reductase-thymidylate synthase 351
L. major   LmjF.12.0220   OG5_127291   hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 351
L. major   LmjF.30.2970   OG5_126628   glyceraldehyde 3-phosphate dehydrogenase, glycosomal 351
L. major   LmjF.27.1870   OG5_134306   trypanothione synthetase, putative 341
L. major   LmjF.06.0560   OG5_143192   deoxyuridine triphosphatase, putative,dUTP diphosphatase 341
L. major   LmjF.08.1010   OG5_126607   cathepsin L-like protease 331
L. major   LmjF.36.0550   OG5_126712   cell division related protein kinase 2,cdc2-related kinase 316
L. major   LmjF.32.1820   OG5_126676   iron superoxide dismutase, putative 316
L. major   LmjF.36.1260   OG5_127143   fructose-1,6-bisphosphate aldolase 316
L. major   LmjF.21.0845   OG5_127374   hypoxanthine-guanine phosphoribosyltransferase 316
L. major   LmjF.18.0990   OG5_128034   UDP-glucose pyrophosphorylase 316
L. major   LmjF.35.0030   OG5_126685   pyruvate kinase 316
L. major   LmjF.32.1830   OG5_126676   iron superoxide dismutase, putative 316