pI: 6.3376 |
Length (AA): 404 |
MW (Da): 46112 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
7 | 400 | 2ixo (A) | 12 | 314 | 33.00 | 0 | 1 | 1.04385 | -0.15 |
10 | 401 | 2ixm (A) | 25 | 318 | 39.00 | 0 | 1 | 1.1261 | -0.36 |
11 | 400 | 2ixn (A) | 3 | 299 | 37.00 | 0 | 1 | 1.11295 | -0.24 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127213)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G08960 | phosphotyrosyl phosphatase activator (PTPA) family protein |
Babesia bovis | BBOV_IV010340 | phosphotyrosyl phosphatase activator, putative |
Brugia malayi | Bm1_28280 | protein phosphatase 2A, regulatory subunit B' |
Candida albicans | CaO19.14084 | Resistant to Rapamycin Deletion |
Candida albicans | CaO19.14195 | rapamycin sensitivity |
Candida albicans | CaO19.6792 | Resistant to Rapamycin Deletion |
Candida albicans | CaO19.6933 | rapamycin sensitivity |
Caenorhabditis elegans | CELE_Y71H2AM.20 | Protein Y71H2AM.20, isoform B |
Cryptosporidium hominis | Chro.10277 | phosphotyrosyl phosphatase activator protein-related |
Cryptosporidium parvum | cgd1_2470 | phosphotyrosyl phosphatase activator protein-related |
Dictyostelium discoideum | DDB_G0270036 | phosphotyrosyl phosphatase activator |
Dictyostelium discoideum | DDB_G0279655 | hypothetical protein |
Drosophila melanogaster | Dmel_CG3289 | Phosphotyrosyl phosphatase activator |
Echinococcus granulosus | EgrG_000242700 | serine:threonine protein phosphatase 2A |
Entamoeba histolytica | EHI_098850 | protein phosphatase regulatory subunit, putative |
Echinococcus multilocularis | EmuJ_000242700 | serine:threonine protein phosphatase 2A |
Giardia lamblia | GL50803_10612 | Phosphotyrosyl phosphatase activator protein, putative |
Homo sapiens | ENSG00000119383 | protein phosphatase 2A activator, regulatory subunit 4 |
Leishmania braziliensis | LbrM.07.0190 | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative |
Leishmania donovani | LdBPK_070350.1 | protein phosphatase 2A, regulatory subunit B, putative |
Leishmania infantum | LinJ.07.0350 | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative |
Leishmania major | LmjF.07.0190 | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative |
Leishmania mexicana | LmxM.07.0190 | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative |
Loa Loa (eye worm) | LOAG_07359 | hypothetical protein |
Mus musculus | ENSMUSG00000039515 | protein phosphatase 2A activator, regulatory subunit B |
Neospora caninum | NCLIV_015300 | phosphotyrosyl phosphatase activator, putative |
Oryza sativa | 4340511 | Os06g0219800 |
Onchocerca volvulus | OVOC2182 | Putative phosphotyrosyl phosphatase activator |
Plasmodium berghei | PBANKA_1014600 | serine/threonine protein phosphatase 2A activator, putative |
Plasmodium falciparum | PF3D7_1430100 | serine/threonine protein phosphatase 2A activator |
Plasmodium knowlesi | PKNH_1328600 | serine/threonine protein phosphatase 2A activator, putative |
Plasmodium vivax | PVX_085035 | serine/threonine protein phosphatase 2A activator, putative |
Plasmodium yoelii | PY01269 | protein phosphatase 2a, regulatory subunit b' |
Saccharomyces cerevisiae | YIL153W | peptidylprolyl isomerase RRD1 |
Saccharomyces cerevisiae | YPL152W | peptidylprolyl isomerase RRD2 |
Schistosoma japonicum | Sjp_0303020 | ko:K01802 peptidylprolyl isomerase [EC5.2.1.8], putative |
Schistosoma mansoni | Smp_166290 | phosphotyrosyl phosphatase activator |
Schmidtea mediterranea | mk4.000519.10 | Putative phosphotyrosyl phosphatase activator |
Trypanosoma brucei gambiense | Tbg972.8.1320 | protein phosphatase 2A, regulatory subunit B, putative,phosphotyrosyl phosphate activator protein, putative |
Trypanosoma brucei | Tb927.8.1710 | protein phosphatase 2A, regulatory subunit B, putative |
Trypanosoma congolense | TcIL3000_8_1600 | protein phosphatase 2A, regulatory subunit B, putative |
Trypanosoma cruzi | TcCLB.505071.90 | protein phosphatase 2A, regulatory subunit B, putative |
Trypanosoma cruzi | TcCLB.511395.30 | protein phosphatase 2A, regulatory subunit B, putative |
Toxoplasma gondii | TGME49_283720 | phosphotyrosyl phosphate activator (ptpa) protein |
Theileria parva | TP01_0695 | phosphotyrosyl phosphatase activator, putative |
Trichomonas vaginalis | TVAG_216210 | phosphotyrosyl phosphatase activator, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.1710 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.1710 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.1710 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.1710 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_Y71H2AM.20 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y71H2AM.20 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y71H2AM.20 | Caenorhabditis elegans | slow growth | wormbase |
CELE_Y71H2AM.20 | Caenorhabditis elegans | sterile | wormbase |
TGME49_283720 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | protein phosphatase 2A activator, regulatory subunit 4 | Compounds | References |
1 literature reference was collected for this gene.