pI: 8.0631 |
Length (AA): 434 |
MW (Da): 45944 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 421 | 3ccz (A) | 451 | 860 | 50.00 | 0 | 1 | 1.55411 | -0.39 |
11 | 47 | 4fqj (A) | 48 | 83 | 42.00 | 0.98 | 0.14 | 0.364301 | 1.01 |
60 | 118 | 1v7r (A) | 86 | 144 | 32.00 | 0.33 | 0.31 | 0.642961 | 0.99 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127955)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G76490 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 |
Arabidopsis thaliana | AT2G17370 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 |
Brugia malayi | Bm1_54020 | Hydroxymethylglutaryl-coenzyme A reductase family protein |
Candida albicans | CaO19.1031 | hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) |
Candida albicans | CaO19.8633 | hydroxymethylglutaryl-CoA reductase (ergosterol biosynthesis) |
Caenorhabditis elegans | CELE_F08F8.2 | Protein HMGR-1 |
Dictyostelium discoideum | DDB_G0276615 | hmg CoA reductase B |
Dictyostelium discoideum | DDB_G0269142 | hmg CoA reductase A |
Drosophila melanogaster | Dmel_CG10367 | HMG Coenzyme A reductase |
Echinococcus granulosus | EgrG_000630800 | hydroxymethylglutaryl coenzyme A reductase |
Echinococcus multilocularis | EmuJ_000630800 | hydroxymethylglutaryl coenzyme A reductase |
Homo sapiens | ENSG00000113161 | 3-hydroxy-3-methylglutaryl-CoA reductase |
Leishmania braziliensis | LbrM.30.3180 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Leishmania donovani | LdBPK_303230.1 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Leishmania infantum | LinJ.30.3230 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Leishmania major | LmjF.30.3190 | 3-hydroxy-3-methylglutaryl-CoA reductase |
Leishmania mexicana | LmxM.29.3190 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Loa Loa (eye worm) | LOAG_01960 | hypothetical protein |
Mus musculus | ENSMUSG00000021670 | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
Mycobacterium ulcerans | MUL_3522 | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase |
Oryza sativa | 4347443 | Os09g0492700 |
Oryza sativa | 9272427 | Os02g0713900 |
Oryza sativa | 4346017 | Os08g0512700 |
Saccharomyces cerevisiae | YML075C | hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 |
Saccharomyces cerevisiae | YLR450W | hydroxymethylglutaryl-CoA reductase (NADPH) HMG2 |
Schistosoma japonicum | Sjp_0210190 | ko:K00021 3-hydroxy-3-methylglutaryl-CoA reductase [EC1.1.1.34], putative |
Schistosoma mansoni | Smp_138590 | hydroxymethylglutaryl-CoA reductase (NADPH) |
Schmidtea mediterranea | mk4.000523.07 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Schmidtea mediterranea | mk4.000523.08 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
Trypanosoma brucei gambiense | Tbg972.6.4330 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Trypanosoma brucei | Tb927.6.4540 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Trypanosoma congolense | TcIL3000_6_3990 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Trypanosoma cruzi | TcCLB.506831.40 | 3-hydroxy-3-methylglutaryl-CoA reductase |
Trypanosoma cruzi | TcCLB.509167.20 | 3-hydroxy-3-methylglutaryl-CoA reductase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4540 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4540 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4540 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.6.4540 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F08F8.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F08F8.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F08F8.2 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F08F8.2 | Caenorhabditis elegans | sterile | wormbase |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | Compounds | References |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | Compounds | References |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | Compounds | References |
Rattus norvegicus | HMG-CoA reductase | Compounds | References |
Sus scrofa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Compounds | References |
Mesocricetus auratus | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Compounds | References |
Homo sapiens | 3-hydroxy-3-methylglutaryl-CoA reductase | Compounds | References |
Mus musculus | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | Compounds | References |
1 literature reference was collected for this gene.