pI: 10.4631 |
Length (AA): 364 |
MW (Da): 41621 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
282 | 355 | 5hmo (A) | 801 | 876 | 34.00 | 0.023 | 0.01 | 0.511397 | -1.13 |
291 | 349 | 5uh7 (A) | 55 | 113 | 19.00 | 0 | 0.01 | 0.615288 | -2.87 |
299 | 356 | 5j45 (A) | 26 | 86 | 33.00 | 0.33 | 0.15 | 0.705441 | -2.57 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127732)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G61770 | Peter Pan-like protein |
Babesia bovis | BBOV_III005130 | Brix domain containing protein |
Brugia malayi | Bm1_48640 | Brix domain containing protein |
Candida albicans | CaO19.6589 | brix domain protein similar to S. cerevisiae SSF1 () and SSF2 (YDR312W) nucleolar proteins involved in ribosomal large subunit b |
Caenorhabditis elegans | CELE_K09H9.6 | Protein LPD-6 |
Cryptosporidium hominis | Chro.80392 | RNA-binding protein |
Cryptosporidium parvum | cgd8_3390 | S.cerevisiae Ssf2p/drosophila peter pan like protein that has an IMP4 domain at its N-terminus and is involved in rRNA processin |
Dictyostelium discoideum | DDB_G0285515 | brix domain-containing protein |
Drosophila melanogaster | Dmel_CG5786 | peter pan |
Echinococcus granulosus | EgrG_000921700 | zinc finger protein 598 |
Echinococcus granulosus | EgrG_000921600 | peter pan |
Entamoeba histolytica | EHI_012190 | brix domain containing protein |
Echinococcus multilocularis | EmuJ_000921600 | peter pan |
Echinococcus multilocularis | EmuJ_000921700 | zinc finger protein 598 |
Giardia lamblia | GL50803_15566 | Peter pan protein |
Homo sapiens | ENSG00000244165 | purinergic receptor P2Y, G-protein coupled, 11 |
Homo sapiens | ENSG00000130810 | peter pan homolog (Drosophila) |
Homo sapiens | ENSG00000243207 | PPAN-P2RY11 readthrough |
Leishmania braziliensis | LbrM.03.0810 | peter pan protein, putative |
Leishmania donovani | LdBPK_030880.1 | peter pan protein, putative |
Leishmania infantum | LinJ.03.0880 | peter pan protein, putative |
Leishmania major | LmjF.03.0900 | peter pan protein, putative |
Leishmania mexicana | LmxM.03.0900 | peter pan protein, putative |
Loa Loa (eye worm) | LOAG_05530 | brix domain-containing protein |
Mus musculus | ENSMUSG00000004100 | peter pan homolog (Drosophila) |
Neospora caninum | NCLIV_033880 | hypothetical protein |
Oryza sativa | 4332803 | Os03g0343700 |
Onchocerca volvulus | OVOC969 | Peter pan protein homolog |
Plasmodium berghei | PBANKA_0711700 | BRIX domain, putative |
Plasmodium falciparum | PF3D7_0819100 | BRIX domain, putative |
Plasmodium knowlesi | PKNH_1312900 | BRIX domain, putative |
Plasmodium vivax | PVX_089410 | hypothetical protein, conserved |
Saccharomyces cerevisiae | YHR066W | Ssf1p |
Saccharomyces cerevisiae | YDR312W | Ssf2p |
Schistosoma japonicum | Sjp_0008560 | ko:K08709 nuclear receptor, other families, insect, putative |
Schistosoma japonicum | Sjp_0310700 | expressed protein |
Schistosoma japonicum | Sjp_0216170 | ko:K08387 purinergic receptor P2Y, G protein-coupled, 11, putative |
Schistosoma japonicum | Sjp_0123230 | hypothetical protein |
Schistosoma mansoni | Smp_181500 | peter pan-related |
Schistosoma mansoni | Smp_173890 | peter pan-related |
Schmidtea mediterranea | mk4.004364.01 | Protein Peter pan |
Schmidtea mediterranea | mk4.000152.13 | Zinc finger protein 598 |
Trypanosoma brucei gambiense | Tbg972.3.2900 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.3.2830 | brix domain containing protein, putative |
Trypanosoma congolense | TcIL3000_3_1730 | peter pan protein, putative |
Trypanosoma cruzi | TcCLB.508153.830 | peter pan protein, putative |
Trypanosoma cruzi | TcCLB.508181.130 | peter pan protein, putative |
Toxoplasma gondii | TGME49_273840 | brix domain-containing protein |
Theileria parva | TP02_0441 | hypothetical protein |
Trichomonas vaginalis | TVAG_363770 | ssf, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.3.2830 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.3.2830 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.3.2830 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.3.2830 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_K09H9.6 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_K09H9.6 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_K09H9.6 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_K09H9.6 | Caenorhabditis elegans | slow growth | wormbase |
CELE_K09H9.6 | Caenorhabditis elegans | sterile | wormbase |
TGME49_273840 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2Y, G-protein coupled, 11 | Compounds | References |
Homo sapiens | PPAN-P2RY11 readthrough | Compounds | References |
1 literature reference was collected for this gene.