Detailed view for PF3D7_0804800

Basic information

TDR Targets ID: 1054
Plasmodium falciparum, peptidyl-prolyl cis-trans isomerase
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 6.7411 | Length (AA): 217 | MW (Da): 24892 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00160   Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD

Gene Ontology

Mouse over links to read term descriptions.
GO:0016018   cyclosporin A binding  
GO:0000413   protein peptidyl-prolyl isomerization  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

Spliceosome (KEGG)

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
22 215 2b71 (A) 23 190 41.00 0 1 1.24 -0.91
32 217 1z81 (A) 25 210 90.00 0 1 2.03 -1.86
5 96 4r6j (A) 141 230 29.00 0.42 0.55 0.509763 0.1
32 217 1z81 (A) 25 210 90.00 0 1 1.98414 -1.37
43 217 1mzw (A) 6 177 60.00 0 1 1.63825 -1.51

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 1Z81:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 24 hs, sporozoite, early ring, late ring, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 32 hs, gametocyte, early trophozoite, late trophozoite, Sporozoite, Female Gametocyte, Male Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, early schizont, late schizont. Otto TD PlasmoDB
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_129014)

Species Accession Gene Product
Arabidopsis thaliana AT2G38730   cyclophilin-like peptidyl-prolyl cis-trans isomerase family protein
Babesia bovis BBOV_IV012070   peptidyl-prolyl cis-trans isomerase, putative
Brugia malayi Bm1_25705   peptidyl-prolyl cis-trans isomerase 11
Caenorhabditis elegans CELE_T01B7.4   Protein CYN-11
Cryptosporidium hominis Chro.80184   cyclophilin
Cryptosporidium parvum cgd8_1560   cyclophilin type peptidyl-prolyl cis-trans isomerase
Dictyostelium discoideum DDB_G0274281   U4/U6 small nuclear ribonucleoprotein
Drosophila melanogaster Dmel_CG17266   CG17266 gene product from transcript CG17266-RA
Echinococcus granulosus EgrG_000525910   U snRNP-associated cyclophilin protein
Entamoeba histolytica EHI_020340   peptidyl-prolyl cis-trans isomerase, putative
Echinococcus multilocularis EmuJ_000525910   U snRNP-associated cyclophilin protein
Homo sapiens ENSG00000171960   peptidylprolyl isomerase H (cyclophilin H)
Loa Loa (eye worm) LOAG_08071   peptidyl-prolyl cis-trans isomerase 11
Mus musculus 433064   predicted gene, 17748
Mus musculus ENSMUSG00000060288   peptidyl prolyl isomerase H
Neospora caninum NCLIV_014620   peptidyl-prolyl cis-trans isomerase H, putative
Oryza sativa 4334542   Os03g0811600
Plasmodium berghei PBANKA_1225800   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium falciparum PF3D7_0804800   peptidyl-prolyl cis-trans isomerase
Plasmodium knowlesi PKNH_0114400   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium vivax PVX_093520   peptidyl-prolyl cis-trans isomerase, putative
Plasmodium yoelii PY00382   cyclophilin
Schistosoma japonicum Sjp_0041570   ko:K09567 peptidyl-prolyl isomerase H (cyclophilin H), putative
Schistosoma mansoni Smp_173280   peptidyl-prolyl cis-trans isomerase h ppih
Schmidtea mediterranea mk4.004875.02   Peptidyl-prolyl cis-trans isomerase 11
Schmidtea mediterranea mk4.003345.00   Peptidyl-prolyl cis-trans isomerase 11
Toxoplasma gondii TGME49_285760   U-snRNP-associated cyclophilin family protein
Theileria parva TP01_1103   cyclophilin, putative
Trichomonas vaginalis TVAG_047830   cyclophilin, putative

Essentiality

PF3D7_0804800 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
PBANKA_1225800 Plasmodium berghei Essential plasmo
TGME49_285760 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Rattus norvegicus Cyclophilin A 164 aa 50.3% 171 aa Compounds References
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase 171 aa 52.4% 170 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

  • Assay for FK-Binding Protein Peptidyl-Prolyl Isomerase Activity (5.2.1.8 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 )

Reagent availability

  • Reagent:
  • Target Type Source Notes
    PF3D7_0804800 purified protein BRENDA A protein with this EC number or name or sequence has been purified from Plasmodium falciparum ( 2 )

Bibliographic References

13 literature references were collected for this gene.

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Gene identifier PF3D7_0804800 (Plasmodium falciparum), peptidyl-prolyl cis-trans isomerase
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