Detailed view for Tb927.11.1690

Basic information

TDR Targets ID: 10718
Trypanosoma brucei, Emopamil binding protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.5531 | Length (AA): 183 | MW (Da): 20428 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 4

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF05241   Emopamil binding protein

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0005783   endoplasmic reticulum  
GO:0047750   cholestenol delta-isomerase activity  
GO:0016125   sterol metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_134510)

Species Accession Gene Product
Caenorhabditis elegans CELE_ZK84.2   Protein ZK84.2
Caenorhabditis elegans CELE_Y38H6C.16   Protein Y38H6C.16
Leishmania braziliensis LbrM.27.1180   hypothetical protein, conserved
Leishmania donovani LdBPK_270960.1   Emopamil binding protein, putative
Leishmania infantum LinJ.27.0960   hypothetical protein, conserved
Leishmania major LmjF.27.1090   hypothetical protein, conserved
Leishmania mexicana LmxM.27.1090   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_05727   hypothetical protein
Onchocerca volvulus OVOC13475  
Trypanosoma brucei gambiense Tbg972.11.1810   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.1690   Emopamil binding protein, putative
Trypanosoma congolense TcIL3000.11.1470   Emopamil binding protein, putative
Trypanosoma cruzi TcCLB.506629.50   Emopamil binding protein, putative
Trypanosoma cruzi TcCLB.509831.30   Emopamil binding protein, putative

Essentiality

Tb927.11.1690 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb11.55.0011 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (3 days) alsford
Tb11.55.0011 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.55.0011 this record Trypanosoma brucei significant loss of fitness in procyclic forms alsford
Tb11.55.0011 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0308 0.3614 0.3586
0.0302 0.6055 0.8163
0.0406 0.2742 0.2742
0.028 0.2928 0.3605
0.0157 0.2965 0.2367
0.0157 0.309 1
0.0152 0.7055 1
0.0164 0.3476 0.3382
0.0278 0.3463 0
0.0411 0.2696 0.2694
0.0146 0.5689 1
0.0274 0.3071 0.3362
0.0428 0.4985 1
0.0135 1 1
0.0278 0.3018 0
0.0278 0.3304 0.5071
0.0424 0.2696 0.2584
0.0291 0.3476 0
0.0166 0.3347 0.3347
0.0302 0.6055 0.8163
0.0166 0.3334 0.3275
0.0138 0.3388 0.3376
0.0149 0.3481 0.3291
0.029 0.3501 0.3394
0.0267 0.3273 0.3605
0.0273 0.2951 0.3605
0.0565 0.3693 0.3692
0.0276 0.2871 0.3613
0.028 0.3423 0
0.0149 0.3481 0.3291
0.0284 0.2838 0.366
0.0742 0.2704 0.269
0.0152 0.3578 0.3422
0.0285 0.3477 0
0.0303 0.2876 0
0.0424 0.2778 0.2763
0.0283 0.2949 0.3605
0.0147 0.3152 0.3313
0.027 0.3589 0.3533
0.027 0.2951 0.3605
0.0281 0.2848 0.3568
0.0147 0.3305 0
0.0149 0.5698 1
0.0137 0.3878 0
0.0267 0.2906 0.3598
0.0138 0.4173 1
0.0451 0.3582 0
0.0158 0.3381 0.3249
0.0277 0.3269 0.3591
0.0267 0.2906 0.3598
0.0437 0.2742 0.2742
0.0416 0.2554 0.2686
0.014 0.3213 0
0.0406 0.2742 0.2742
0.0166 0.3398 0.3242
0.0277 0.3269 0.3591
0.029 0.7936 0.7936
0.0276 0.2934 0.3605
0.0424 0.2763 0.2763
0.0314 0.3232 0
0.056 0.2888 0.2885
0.0542 0.3649 0.3734
0.0276 0.2958 0.3642
0.0429 0.278 0.2763
0.0267 0.2954 0.3626
0.0278 0.3613 0.3547
0.0149 0.2955 0.1874
0.0144 0.3068 0
0.0276 0.2934 0.3605
0.028 0.2954 0.3605
0.0166 0.3632 0.3357
0.0133 0.3442 0.344
0.0426 0.3668 0.3664
0.0134 0.2927 0.3553
0.1168 0.3273 0.3261
0.0296 0.3423 0.3423
0.0273 0.2623 0.3566
0.0166 0.3334 0.3275
0.1416 0.3294 0.4072
0.0136 0.6075 1
0.0284 0.36 0
0.028 0.258 0
0.0286 0.3665 0.356
0.0416 0.2755 0.2739
0.0146 1 1
0.0411 0.2755 0.2739
0.0406 0.2742 0.2742
0.0167 0.3703 0.3689
0.0444 1 1
0.0149 0.31 0.3505
0.0136 0.3254 0.3254
0.0147 0.6003 1
0.0276 0.2934 0.3605
0.0421 0.2739 0.2739
0.0152 0.7055 1
0.0302 0.6055 0.8163
0.0267 0.3591 0.359
0.0133 0.3458 0.3458
0.0443 0.5184 1
0.0406 0.2742 0.2742
0.0166 0.3398 0.3242
0.016 1 0.5
0.0276 0.2949 0.3605
0.0273 0.2951 0.3605
0.0406 0.2742 0.2742
0.0291 0.3387 0
0.0406 0.2755 0.2739
0.0426 0.3668 0.3664
0.0142 0.3222 1
0.0166 0.2687 0.329
0.0156 0.5289 1
0.0135 0.2903 0.3386
0.027 0.3095 0
0.0133 0.2967 0.3442
0.0276 0.2934 0.3605
0.0447 1 1
0.0267 0.3285 0.3613
0.0849 1 0.5
0.028 0.258 0
0.0292 0.33 0.33
0.0276 0.2871 0.3613
0.0708 0.2965 0.2953
0.0277 0.2949 0.3605
0.0136 0.2991 1
0.0266 0.2646 0.3328
0.0135 0.3563 0.3563
0.0144 0.253 1
0.0166 1 0.5
0.0273 0.2702 0.3621
0.0429 0.278 0.2763
0.0269 0.3409 0.315
0.1019 0.3143 0.3113
0.0133 0.3338 1
0.1416 0.3294 0.4072
0.0402 0.3456 0.3209
0.0414 0.2786 0.3692
0.0266 0.2646 0.3328
0.0138 0.2961 1
0.0284 0.2838 0.366
0.0138 0.2958 1
0.0136 0.3038 0
0.029 0.3673 0.3628
0.0266 0.2928 0.3605
0.0936 0.2777 0
0.0283 0.2523 0.2523
0.1416 0.3294 0.4072
0.028 0.3423 0
0.0269 0.3409 0.315
0.0143 0.2938 0
0.0166 0.6449 0.82
0.0704 0.2572 0.2498
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.028 0.258 0
0.0276 0.2934 0.3605
0.1453 0.2919 0.2918
0.0284 0.3299 0
0.028 0.2949 0.3605
0.0273 0.2949 0.3605
0.0429 0.278 0.2763
0.0452 0.3674 0.3671
0.0279 0.3393 0
0.0137 0.3878 0
0.0267 0.2928 0.3605
0.0142 0.5638 1
0.0166 0.3347 0.3347
0.0285 0.3376 0.3376
0.0296 0.3606 0.3562
0.0141 0.3118 1
0.042 0.5262 1
0.0165 0.4153 1
0.0287 0.2969 0.3605
0.0417 0.2767 0.2751
0.0266 0.6106 0.706
0.0412 0.2723 0.2723
0.0146 0.3891 1
0.028 0.2928 0.3605
0.0276 0.2928 0.3605
0.0406 0.2742 0.2742
0.0156 0.307 1
0.0536 0.3683 0.3674
0.0166 0.6449 0.82
0.0402 0.3456 0.3209
0.0406 0.2742 0.2742
0.0406 0.2742 0.2742
0.0149 0.3481 0.3291
0.0272 0.2977 0
0.0266 0.6263 0.7337
0.0136 1 1
0.0138 1 1
0.0138 0.6883 1
0.0285 0.3092 0.7829
0.0135 0.3231 0.3466
0.0406 0.2742 0.2742
0.045 0.3594 0.355
0.0443 0.2756 0.2742
0.0422 0.3689 0.3681
0.0273 0.3977 1
0.0313 0.364 0.3636
0.0135 0.5927 1
0.0686 0.4293 1
0.0704 0.2911 0
0.0445 0.363 0.3571
0.0399 0.2664 0.272
0.0297 0.3565 0.3474
0.0406 0.2742 0.2742
0.0272 0.3027 0
0.0277 0.3269 0.3591
0.0166 0.3347 0.3347
0.0283 0.2951 0.3605
0.0406 0.2742 0.2742
0.0135 0.3462 0.3399
0.0269 0.2679 0.7341
0.0287 0.3568 0.3568
0.0433 0.2735 0.2733
0.0149 0.2761 0
0.0273 0.2949 0.3605
0.0138 0.3468 0
0.0406 0.2742 0.2742
0.0307 0.3492 0
0.0424 0.2763 0.2763
0.0283 0.2949 0.3605
0.0283 0.2932 0.3605
0.0406 0.2742 0.2742
0.0166 0.6449 0.82
0.0406 0.2742 0.2742
0.1416 0.3294 0.4072
0.0273 0.2941 0.3605
0.0424 0.2765 0.2763
0.0137 0.2745 0.3493
0.0284 0.2838 0.366
0.0278 0.3304 0.5071
0.0276 0.2934 0.3605
0.0406 0.2742 0.2742
0.0435 0.2786 0.2763
0.0406 0.2742 0.2742
0.0422 0.2656 0.2656
0.0271 0.5126 1
0.027 0.3147 0
0.0133 0.3338 1
0.0415 0.3601 0.3569
0.0138 0.3388 0.3376
0.0976 0.2603 0.2603
0.028 0.258 0
0.0418 0.2725 0.2725
0.015 0.2965 0.2367
0.015 0.2947 0.2367

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.1690 (Trypanosoma brucei), Emopamil binding protein, putative
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