pI: 6.3532 |
Length (AA): 382 |
MW (Da): 42690 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128136)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G51800 | putative nuclear DNA-binding protein G2p |
Babesia bovis | BBOV_IV005570 | proliferation-associated protein 2g4, putative |
Brugia malayi | Bm1_12685 | DNA-binding protein, 42 kDa containing protein |
Candida albicans | CaO19.6507 | curved-DNA binding protein |
Candida albicans | CaO19_6507 | hypothetical protein |
Candida albicans | CaO19.13860 | curved-DNA binding protein |
Caenorhabditis elegans | CELE_W08E12.7 | Protein W08E12.7 |
Cryptosporidium hominis | Chro.30278 | nuclear DNA-binding protein G2p -related |
Cryptosporidium parvum | cgd3_2390 | proliferation-associated protein 2G4 metalloprotease, creatinase/aminopeptidase fold |
Dictyostelium discoideum | DDB_G0282361 | proliferation associated protein |
Drosophila melanogaster | Dmel_CG10576 | CG10576 gene product from transcript CG10576-RD |
Echinococcus granulosus | EgrG_000781200 | Proliferation associated protein 2G4 |
Entamoeba histolytica | EHI_175020 | peptidase, putative |
Echinococcus multilocularis | EmuJ_000781200 | Proliferation associated protein 2G4 |
Homo sapiens | ENSG00000170515 | proliferation-associated 2G4, 38kDa |
Leishmania braziliensis | LbrM.19.0470 | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania donovani | LdBPK_190150.1 | metallo-peptidase, Clan MG, Family M24 |
Leishmania infantum | LinJ.19.0150 | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania major | LmjF.19.0160 | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Leishmania mexicana | LmxM.19.0160 | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Loa Loa (eye worm) | LOAG_08033 | DNA-binding protein |
Mus musculus | ENSMUSG00000025364 | proliferation-associated 2G4 |
Neospora caninum | NCLIV_038400 | Methionine aminopeptidase (EC 3.4.11.18), related |
Oryza sativa | 4338500 | Os05g0350500 |
Plasmodium berghei | PBANKA_1016300 | proliferation-associated protein 2g4, putative |
Plasmodium falciparum | PF3D7_1428300 | proliferation-associated protein 2g4, putative |
Plasmodium knowlesi | PKNH_1330400 | proliferation-associated protein, putative |
Plasmodium vivax | PVX_085125 | proliferation-associated protein 2g4, putative |
Schistosoma japonicum | Sjp_0128810 | ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative |
Schistosoma mansoni | Smp_150690.1 | proliferation-associated protein 2G4 38kDa (M24 family) |
Schistosoma mansoni | Smp_150690.2 | proliferation-associated protein 2G4 38kDa (M24 family) |
Schmidtea mediterranea | mk4.000573.03 | Proliferation-associated protein 2G4, 38kDa |
Trypanosoma brucei gambiense | Tbg972.10.17950 | aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 |
Trypanosoma brucei | Tb927.10.14790 | metallo-peptidase, Clan MG, Family M24 |
Trypanosoma congolense | TcIL3000_10_12660 | metallo-peptidase, Clan MG, Family M24 |
Trypanosoma cruzi | TcCLB.506211.200 | metallo-peptidase, Clan MG, Family M24 |
Trypanosoma cruzi | TcCLB.511289.30 | metallo-peptidase, Clan MG, Family M24 |
Toxoplasma gondii | TGME49_279390 | proliferation-associated protein 2G4, putative |
Theileria parva | TP01_0364 | proliferation-associated protein 2g4, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.14790 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.14790 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.14790 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.14790 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_279390 | Toxoplasma gondii | Essentiality uncertain | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.3
1 literature reference was collected for this gene.