Detailed view for Tb927.9.3350
Basic information
Trypanosoma brucei, pseudouridylate synthase, putative
Source Database / ID: TriTrypDB GeneDB
pI: 9.7712 |
Length (AA): 406 |
MW (Da): 46295 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Network
Pfam domains
Gene Ontology
GO:0009982 pseudouridine synthase activity
GO:0003723 RNA binding
GO:0009451 RNA modification
GO:0006396 RNA processing
GO:0001522 pseudouridine synthesis
Metabolic Pathways
Structural information
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
| Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
|---|---|---|---|---|---|---|---|---|---|
| 158 | 393 | 1v9k (A) | 93 | 315 | 25.00 | 0.000000048 | 1 | 0.839081 | 0.07 |
| 158 | 393 | 1v9k (A) | 93 | 315 | 23.00 | 0 | 1 | 0.845481 | -0.11 |
| 160 | 367 | 5uba (A) | 99 | 330 | 32.00 | 0 | 1 | 0.736115 | 0.61 |
Help me make sense of these data.
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Expression
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 80-100% percentile | Procyclic. | Siegel TN |
| Upregulation Percent | Ranking | Stage | Dataset |
|---|---|---|---|
| Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
-
Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.
Orthologs
Ortholog group members (OG5_129784)
| Species | Accession | Gene Product |
|---|---|---|
| Arabidopsis thaliana | AT3G19440 | RNA pseudourine synthase 4 |
| Brugia malayi | Bm1_08265 | RNA pseudouridylate synthase family protein |
| Dictyostelium discoideum | DDB_G0285543 | hypothetical protein |
| Echinococcus granulosus | EgrG_000842200 | methylmalonic aciduria and homocystinuria type D |
| Echinococcus granulosus | EgrG_000878300 | Pseudouridine synthase domain containing protein |
| Echinococcus multilocularis | EmuJ_000878300 | Pseudouridine synthase domain containing protein |
| Echinococcus multilocularis | EmuJ_000842200 | methylmalonic aciduria and homocystinuria type D |
| Homo sapiens | ENSG00000165526 | RNA pseudouridylate synthase domain containing 4 |
| Leishmania braziliensis | LbrM.01.0310 | pseudouridylate synthase-like protein |
| Leishmania donovani | LdBPK_010280.1 | pseudouridylate synthase-like protein |
| Leishmania infantum | LinJ.01.0280 | pseudouridylate synthase-like protein |
| Leishmania major | LmjF.01.0280 | pseudouridylate synthase-like protein |
| Leishmania mexicana | LmxM.01.0280 | pseudouridylate synthase-like protein |
| Loa Loa (eye worm) | LOAG_04880 | hypothetical protein |
| Mus musculus | ENSMUSG00000032044 | RNA pseudouridylate synthase domain containing 4 |
| Oryza sativa | 4346373 | Os09g0103500 |
| Onchocerca volvulus | OVOC8102 | Putative ribosomal pseudouridine synthase |
| Schistosoma japonicum | Sjp_0007980 | ko:K06179 ribosomal large subunit pseudouridine synthase C, putative |
| Schistosoma japonicum | Sjp_0303930 | similar to Uncharacterized protein C2orf25 homolog, mitochondrial precursor, putative |
| Schistosoma mansoni | Smp_194510 | ribosomal pseudouridine synthase |
| Schmidtea mediterranea | mk4.001567.07 | Putative ribosomal pseudouridine synthase |
| Schmidtea mediterranea | mk4.001929.04 | |
| Trypanosoma brucei gambiense | Tbg972.9.1670 | pseudouridylate synthase, putative |
| Trypanosoma brucei | Tb927.9.3350 | pseudouridylate synthase, putative |
| Trypanosoma congolense | TcIL3000_9_950 | pseudouridylate synthase, putative |
| Trypanosoma cruzi | TcCLB.511577.90 | pseudouridylate synthase-like protein, putative |
| Trypanosoma cruzi | TcCLB.504797.30 | pseudouridylate synthase-like protein, putative |
| Treponema pallidum | TP0231 | hypothetical protein |
| Wolbachia endosymbiont of Brugia malayi | Wbm0206 | pseudouridylate synthase |
Essentiality
Phenotypes and Validation (curated)
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Annotated validation
Associated compounds / Druggability
Known modulators for this target
Predicted associations
By orthology with druggable targets
By sequence similarity to non orthologous druggable targets
Obtained from network model
Assayability
Assay information
Reagent availability
Bibliographic References