Detailed view for Tb427.10.1140

Basic information

TDR Targets ID: 12023
Trypanosoma brucei, epsilon tubulin

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.1052 | Length (AA): 487 | MW (Da): 53101 | Paralog Number: 1010

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Pfam domains

PF00091   Tubulin/FtsZ family, GTPase domain
PF03953   Tubulin C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0046785   microtubule polymerization  
GO:0043234   protein complex  
GO:0005874   microtubule  
GO:0005525   GTP binding  
GO:0005198   structural molecule activity  
GO:0003924   GTPase activity  
GO:0051258   protein polymerization  
GO:0007018   microtubule-based movement  
GO:0007017   microtubule-based process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.5


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Bos taurus Tubulin 85 aa 23.6% 110 aa Compounds References
Trypanosoma brucei beta tubulin 442 aa 29.1% 443 aa Compounds References
Plasmodium falciparum tubulin beta chain 445 aa 29.4% 446 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Trypanosoma brucei alpha tubulin 451 aa 26.5% 476 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Bos taurus Tubulin 445 aa 29.1% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Trypanosoma brucei tubulin gamma chain 447 aa 28.3% 491 aa Compounds References
Sus scrofa Tubulin 445 aa 29.4% 446 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Trypanosoma brucei alpha tubulin 451 aa 26.5% 476 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major epsilon tubulin, putative 470 aa 68.0% 488 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Bos taurus Tubulin beta chain 445 aa 29.1% 443 aa Compounds References
Rattus norvegicus Tubulin alpha-1 chain 451 aa 25.7% 479 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Sus scrofa Tubulin alpha chain 451 aa 25.5% 479 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Leishmania major beta tubulin 443 aa 29.8% 443 aa Compounds References
Plasmodium falciparum alpha tubulin 1 453 aa 26.5% 486 aa Compounds References
Trypanosoma brucei alpha tubulin 451 aa 26.5% 476 aa Compounds References
Ovis aries Tubulin alpha 4a 448 aa 26.1% 479 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major gamma-tubulin 447 aa 28.1% 491 aa Compounds References
Trypanosoma brucei alpha tubulin 451 aa 26.5% 476 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References
Leishmania major alpha tubulin 451 aa 26.1% 476 aa Compounds References

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0328 0.447 0.5589
0.046 0.2733 0.4431
0.0294 0.4845 0.3816
0.0507 0.2651 0.2651
0.0182 0.3842 0.2754
0.0284 0.3195 0.5393
0.2094 0.5351 0.5351
0.0902 0.2749 0.5512
0.044 0.5284 0.5262
0.0236 0.6661 1
0.0137 0.5054 0.4188
0.0145 0.3544 0.3392
0.0261 0.2564 0.543
0.0116 0.3065 0.2648
0.0407 0.5054 0.5271
0.0134 0.3347 0
0.007 0.2831 0.7825
0.028 0.3145 0.3784
0.0505 0.5684 0.5684
0.0196 0.3729 0.3729
0.0987 0.2669 0.5326
0.0125 0.3392 0.3392
0.0549 0.448 0.448
0.0135 0.3392 0.3392
0.0344 0.3407 0.5303
0.2043 0.5382 0.5381
0.0132 0.462 0.4008
0.0268 0.5259 0.4188
0.0395 0.5316 0.5306
0.0348 0.336 0.3357
0.0181 0.3287 0.3583
0.0139 0.4532 0.4008
0.0286 0.2721 0.2721
0.1405 0.5136 0.5045
0.0134 0.253 0
0.2048 0.4878 0.5381
0.1408 0.4595 0.5516
0.0179 0.3551 0.3551
0.0798 0.4597 0.3418
0.0431 0.3843 0.3309
0.0577 0.5585 0.5585
0.1147 0.3352 0.5678
0.0522 0.2879 0.4873
0.2053 0.5373 0.5371
0.0885 0.2746 0.551
0.0417 0.3295 0.5271
0.0131 0.3392 0.3392
0.0294 0.4845 0.3816
0.0136 0.3392 0.3392
0.0289 0.3725 0.3725
0.1813 0.552 0.552
0.104 0.2906 0.5329
0.013 0.5084 0.4008
0.0282 0.3142 0.3401
0.0873 0.5375 0.5354
0.0263 0.3178 0.2732
0.0251 0.5402 0.5386
0.0249 0.3749 0.3587
0.0127 0.3392 0.3392
0.2141 0.5326 0.5326
0.0253 0.3918 0.3918
0.013 0.326 0.3078
0.0139 0.3392 0.3392
0.1055 0.5384 0.5384
0.0273 0.3209 0.5017
0.0522 0.2879 0.4873
0.2048 0.4878 0.5381
0.0123 0.4335 0.4008
0.0872 0.3603 0.5535
0.0145 0.3392 0.3392
0.0136 0.3392 0.3392
0.0184 0.2597 0.5378
0.0491 0.5253 0.5252
0.0298 0.4717 0.3673
0.0129 0.4008 0.4008
0.0362 0.3067 0.5295
0.0207 0.3147 0.2745
0.0135 0.3392 0.3392
0.0134 0.3392 0.3392
0.0914 0.2752 0.5515
0.1567 0.5381 0.5378
0.0958 0.2728 0.5481
0.091 0.5325 0.371
0.0423 0.3287 0.527
0.006 0.2882 1
0.0862 0.5519 0.5478
0.0522 0.2879 0.4873
0.2174 0.4299 0.5319
0.0134 0.3392 0.3392
0.0938 0.2781 0.5491
0.0258 0.3471 0.5248
0.1366 0.5329 0.5325
0.0293 0.2733 0.3261
0.0812 0.4723 0.4723
0.0141 0.3392 0.3392
0.0333 0.3437 0.5306
0.0182 0.4071 0.4035
0.0812 0.4723 0.4723
0.1905 0.5369 0.5367
0.0798 0.4597 0.3418
0.101 0.2787 0.546
0.0292 0.5476 0.5443
0.0145 0.5091 0.3748
0.0902 0.2745 0.551
0.0584 0.5546 0.5546
0.0812 0.4723 0.4723
0.0258 0.3496 0.2724
0.0559 0.5037 0.5037
0.2048 0.4878 0.5381
0.1574 0.538 0.5377

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Tb427.10.1140 (Trypanosoma brucei), epsilon tubulin
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