pI: 6.9671 |
Length (AA): 543 |
MW (Da): 59690 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127094)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G44170 | aldehyde dehydrogenase 3H1 |
Arabidopsis thaliana | AT4G34240 | aldehyde dehydrogenase 3I1 |
Brugia malayi | Bm1_51685 | Aldehyde dehydrogenase protein 4 |
Candida albicans | CaO19_6518 | hypothetical protein |
Candida albicans | CaO19.13487 | similar to aldehyde dehydrogenases |
Candida albicans | CaO19.6518 | similar to aldehyde dehydrogenases |
Candida albicans | CaO19.13871 | similar to aldehyde dehydrogenases |
Candida albicans | CaO19.6066 | similar to aldehyde dehydrogenases |
Caenorhabditis elegans | CELE_T08B1.3 | Protein ALH-5 |
Caenorhabditis elegans | CELE_T05H4.13 | Protein ALH-4, isoform C |
Dictyostelium discoideum | DDB_G0292270 | aldehyde dehydrogenase |
Drosophila melanogaster | Dmel_CG11140 | Aldehyde dehydrogenase type III |
Echinococcus granulosus | EgrG_001100700 | ras gtp binding protein rho1 |
Echinococcus granulosus | EgrG_000583800 | aldehyde dehydrogenase family 3 member B1 |
Echinococcus granulosus | EgrG_000608100 | Fatty aldehyde dehydrogenase |
Entamoeba histolytica | EHI_042140 | aldehyde dehydrogenase 1, putative |
Echinococcus multilocularis | EmuJ_000583800 | aldehyde dehydrogenase family 3 member B1 |
Echinococcus multilocularis | EmuJ_001100700 | ras gtp binding protein rho1 |
Echinococcus multilocularis | EmuJ_000608100 | Fatty aldehyde dehydrogenase |
Homo sapiens | ENSG00000108602 | aldehyde dehydrogenase 3 family, member A1 |
Homo sapiens | ENSG00000132746 | aldehyde dehydrogenase 3 family, member B2 |
Homo sapiens | ENSG00000072210 | aldehyde dehydrogenase 3 family, member A2 |
Homo sapiens | ENSG00000006534 | aldehyde dehydrogenase 3 family, member B1 |
Loa Loa (eye worm) | LOAG_07638 | aldehyde dehydrogenase 4 |
Mycobacterium leprae | ML2639c | PROBABLE ALDEHYDE DEHYDROGENASE (NAD+) DEPENDENT |
Mus musculus | ENSMUSG00000019102 | aldehyde dehydrogenase family 3, subfamily A1 |
Mus musculus | ENSMUSG00000075296 | aldehyde dehydrogenase 3 family, member B2 |
Mus musculus | ENSMUSG00000010025 | aldehyde dehydrogenase family 3, subfamily A2 |
Mus musculus | 102643082 | aldehyde dehydrogenase family 3 member B1-like |
Mus musculus | 73458 | RIKEN cDNA 1700055N04 gene |
Mus musculus | ENSMUSG00000024885 | aldehyde dehydrogenase 3 family, member B1 |
Mycobacterium tuberculosis | Rv0147 | Probable aldehyde dehydrogenase (NAD+) dependent |
Mycobacterium ulcerans | MUL_4760 | aldehyde dehydrogenase (NAD+) dependent |
Oryza sativa | 4349966 | Os11g0186200 |
Onchocerca volvulus | OVOC6843 | Aldehyde dehydrogenase homolog |
Saccharomyces cerevisiae | YMR110C | Hfd1p |
Schistosoma japonicum | Sjp_0057270 | ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative |
Schistosoma japonicum | Sjp_0207190 | Rho-related GTP-binding protein RhoC precursor, putative |
Schistosoma mansoni | Smp_172730 | aldehyde dehydrogenase |
Schmidtea mediterranea | mk4.002506.03 | Putative aldehyde dehydrogenase |
Schmidtea mediterranea | mk4.046047.00 | |
Trypanosoma brucei gambiense | Tbg972.6.2840 | aldehyde dehydrogenase family, putative |
Trypanosoma brucei | Tb927.6.3050 | aldehyde dehydrogenase family, putative |
Trypanosoma congolense | TcIL3000_6_2570 | aldehyde dehydrogenase family, putative |
Trypanosoma congolense | TcIL3000_0_08790 | aldehyde dehydrogenase family, putative |
Trypanosoma cruzi | TcCLB.507023.120 | aldehyde dehydrogenase family, putative |
Trypanosoma cruzi | TcCLB.511751.120 | aldehyde dehydrogenase family, putative |
Trichomonas vaginalis | TVAG_346790 | succinate semialdehyde dehydrogenase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu148 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.6.3050 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.3050 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.3050 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.6.3050 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T05H4.13 | Caenorhabditis elegans | adult lethal | wormbase |
CELE_T05H4.13 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T05H4.13 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T05H4.13 | Caenorhabditis elegans | slow growth | wormbase |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 3 family, member A1 | Compounds | References |
1 literature reference was collected for this gene.