pI: 5.7722 |
Length (AA): 332 |
MW (Da): 36627 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127238)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G12230 | transaldolase-like protein |
Brugia malayi | Bm1_04195 | Transaldolase |
Candida albicans | CaO19.11849 | Transaldolase |
Candida albicans | CaO19.4371 | Transaldolase |
Caenorhabditis elegans | CELE_Y24D9A.8 | Protein Y24D9A.8, isoform B |
Chlamydia trachomatis | CT_313 | transaldolase |
Dictyostelium discoideum | DDB_G0280909 | hypothetical protein |
Drosophila melanogaster | Dmel_CG2827 | CG2827 gene product from transcript CG2827-RA |
Escherichia coli | b3946 | fructose-6-phosphate aldolase 2 |
Escherichia coli | b2464 | transaldolase A |
Escherichia coli | b0008 | transaldolase B |
Escherichia coli | b0825 | fructose-6-phosphate aldolase 1 |
Echinococcus granulosus | EgrG_000092800 | transaldolase |
Echinococcus multilocularis | EmuJ_000092800 | transaldolase |
Homo sapiens | ENSG00000177156 | transaldolase 1 |
Leishmania braziliensis | LbrM.16.0750 | transaldolase, putative |
Leishmania donovani | LdBPK_160760.1 | transaldolase, putative |
Leishmania infantum | LinJ.16.0760 | transaldolase, putative |
Leishmania major | LmjF.16.0760 | transaldolase, putative |
Leishmania mexicana | LmxM.16.0760 | transaldolase, putative |
Loa Loa (eye worm) | LOAG_02901 | transaldolase |
Mus musculus | ENSMUSG00000025503 | transaldolase 1 |
Neospora caninum | NCLIV_030290 | transaldolase, putative |
Oryza sativa | 4344683 | Os08g0154300 |
Onchocerca volvulus | OVOC3446 | Transaldolase homolog |
Saccharomyces cerevisiae | YGR043C | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase NQM1 |
Saccharomyces cerevisiae | YLR354C | sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate transaldolase TAL1 |
Schistosoma japonicum | Sjp_0213130 | ko:K00616 transaldolase [EC2.2.1.2], putative |
Schistosoma mansoni | Smp_070600 | transaldolase |
Schmidtea mediterranea | mk4.008991.00 | |
Schmidtea mediterranea | mk4.010083.00 | Probable transaldolase |
Schmidtea mediterranea | mk4.035731.04 | Probable transaldolase |
Schmidtea mediterranea | mk4.035731.03 | |
Trypanosoma brucei gambiense | Tbg972.8.5600 | transaldolase, putative |
Trypanosoma brucei | Tb927.8.5600 | transaldolase, putative |
Trypanosoma congolense | TcIL3000_0_10000 | transaldolase, putative |
Trypanosoma cruzi | TcCLB.503477.20 | transaldolase, putative |
Trypanosoma cruzi | TcCLB.507889.10 | transaldolase, putative |
Toxoplasma gondii | TGME49_229360 | transaldolase |
Trichomonas vaginalis | TVAG_272910 | transaldolase total2, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0686 | translaldolase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.5600 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.5600 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.5600 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.8.5600 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0008 | Escherichia coli | non-essential | goodall |
b0825 | Escherichia coli | non-essential | goodall |
b2464 | Escherichia coli | non-essential | goodall |
b3946 | Escherichia coli | non-essential | goodall |
TGME49_229360 | Toxoplasma gondii | Probably non-essential | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2
3 literature references were collected for this gene.