Detailed view for Tb927.7.4180

Basic information

TDR Targets ID: 13183
Trypanosoma brucei, Fatty acid elongase

Source Database / ID:  TriTrypDB  GeneDB

pI: 9.6448 | Length (AA): 305 | MW (Da): 33871 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01151   GNS1/SUR4 family

Gene Ontology

Mouse over links to read term descriptions.
GO:0042759   long-chain fatty acid biosynthetic process  
GO:0009922   fatty acid elongase activity  
GO:0030176   integral to endoplasmic reticulum membrane  
GO:0016021   integral to membrane  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127859)

Species Accession Gene Product
Brugia malayi Bm1_08835   Fatty acid elongation protein 3
Brugia malayi Bm1_37910   GNS1/SUR4 family protein
Candida albicans CaO19.908   one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)
Candida albicans CaO19.8526   one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1)
Caenorhabditis elegans CELE_F56H11.4   Protein ELO-1, isoform B
Caenorhabditis elegans CELE_D2024.3   Protein ELO-3, isoform B
Caenorhabditis elegans CELE_C40H1.4   Protein ELO-4
Cryptosporidium hominis Chro.80534   fatty-acyl elongase
Cryptosporidium parvum cgd8_4630   7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase
Dictyostelium discoideum DDB_G0292896   GNS1/SUR4 family protein
Dictyostelium discoideum DDB_G0274669   hypothetical protein
Dictyostelium discoideum DDB_G0272012   GNS1/SUR4 family protein
Dictyostelium discoideum DDB_G0277569   GNS1/SUR4 family protein
Dictyostelium discoideum DDB_G0281821   steroid isomerase
Drosophila melanogaster Dmel_CG3971   CG3971 gene product from transcript CG3971-RA
Homo sapiens ENSG00000170522   ELOVL fatty acid elongase 6
Leishmania braziliensis LbrM.14.0720   fatty acid elongase, putative
Leishmania braziliensis LbrM.14.0630   fatty acid elongase, putative
Leishmania braziliensis LbrM.14.0690   fatty acid elongase, putative
Leishmania donovani LdBPK_140660.1   fatty acid elongase, putative
Leishmania donovani LdBPK_140760.1   fatty acid elongase, putative
Leishmania donovani LdBPK_140800.1   fatty acid elongase, putative
Leishmania infantum LinJ.14.0760   fatty acid elongase, putative
Leishmania infantum LinJ.14.0660   fatty acid elongase, putative
Leishmania infantum LinJ.14.0800   fatty acid elongase, putative
Leishmania major LmjF.14.0640   fatty acid elongase, putative
Leishmania major LmjF.14.0740   fatty acid elongase, putative
Leishmania major LmjF.14.0705   fatty acid elongase, putative
Leishmania mexicana LmxM.14.0740   fatty acid elongase, putative
Leishmania mexicana LmxM.14.0640   fatty acid elongase, putative
Leishmania mexicana LmxM.14.0705   fatty acid elongase, putative
Loa Loa (eye worm) LOAG_05719   GNS1/SUR4 family protein
Loa Loa (eye worm) LOAG_11536   fatty acid elongation protein 3
Mus musculus ENSMUSG00000041220   ELOVL family member 6, elongation of long chain fatty acids (yeast)
Neospora caninum NCLIV_008210   GNS1/SUR4 family domain-containing protein, putative
Neospora caninum NCLIV_020350   GNS1/SUR4 domain containing protein, related
Plasmodium berghei PBANKA_0820900   long chain fatty acid elongation enzyme, putative
Plasmodium falciparum PF3D7_0920000   long chain fatty acid elongation enzyme, putative
Plasmodium falciparum PF3D7_0109300   fatty acid elongation protein, GNS1/SUR4 family, putative
Plasmodium knowlesi PKNH_0718000   fatty acid elongase, putative
Plasmodium vivax PVX_099415   GNS1/SUR4 domain containing protein
Plasmodium yoelii PY03060   unnamed protein product, putative
Plasmodium yoelii PY05248   30 kDa glycoprotein
Saccharomyces cerevisiae YLR372W   fatty acid elongase SUR4
Saccharomyces cerevisiae YJL196C   fatty acid elongase ELO1
Trypanosoma brucei gambiense Tbg972.7.4690   fatty acid elongase, putative
Trypanosoma brucei Tb927.7.4180   Fatty acid elongase
Trypanosoma congolense TcIL3000_7_3360   fatty acid elongase, putative
Trypanosoma cruzi TcCLB.506661.30   fatty acid elongase, putative
Trypanosoma cruzi TcCLB.511245.130   fatty acid elongase, putative
Trypanosoma cruzi TcCLB.511245.160   fatty acid elongase, putative
Trypanosoma cruzi TcCLB.510989.10   fatty acid elongase, putative
Toxoplasma gondii TGME49_253880   GNS1/SUR4 family protein
Toxoplasma gondii TGME49_205350   integral membrane protein, GNS1/SUR4 family protein, putative

Essentiality

Tb927.7.4180 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.4180 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.4180 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.4180 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.4180 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_D2024.3 Caenorhabditis elegans slow growth wormbase
PBANKA_0820900 Plasmodium berghei Dispensable plasmo
TGME49_205350 Toxoplasma gondii Probably non-essential sidik
TGME49_253880 Toxoplasma gondii Probably non-essential sidik
TGME49_205350 Toxoplasma gondii Essentiality uncertain sidik
TGME49_253880 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) normal (PATO:0000461) single cell organism (CARO:0000064) bloodstream stage (PLO:0040) inferred from loss-of-function mutant phenotype (ECO:0000016) Trypanosoma brucei brucei No drug identifiers listed for this gene.
Annotator: ts4@sanger.ac.uk. Comment: . References: 16923389
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens ELOVL fatty acid elongase 6 Compounds References
Mus musculus ELOVL family member 6, elongation of long chain fatty acids (yeast) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.005 1 0.5
0.1651 0.2576 1
0.0642 1 1
0.0405 0.9596 1
0.0392 0.3495 1
0.0638 0.4117 1
0.0398 0.5003 1
0.0921 0.5093 0.4877
0.0449 0.4567 1
0.0325 0.4105 1
0.031 0.3048 1
0.0192 0.4916 1
0.0344 0.3203 1
0.067 1 1
0.0604 1 1
0.0466355 1 1
0.0505 1 1
0.0344 0.3203 1
0.0594 0.6032 1
0.005 0.334 1
0.1651 0.2576 1
0.0513 1 1
0.0879 0.2861 1
0.0391 0.4917 1
0.0827 1 1
0.0804 0.4728 1
0.0405 0.9596 1
0.005 0.5 0.5
0.047 0.5601 1
0.005 0.33 1
0.0308 0.3713 1
0.161 0.2589 1
0.0203 0.5 0.5
0.0165 0.5 0.5
0.0419 0.5073 1
0.0539 1 1
0.0082 0.3889 1
0.0456 1 1
0.0514 0.3649 1
0.0301 0.5578 1
0.0217 0.2625 1
0.161 0.2553 1
0.0545 1 1
0.0921 0.5093 0.4877
0.0545 0.5 0.5
0.0378 0.3776 1
0.0293 0.5 0.5
0.005 1 0.5
0.03 0.9708 1
0.0068 0.5 0.5
0.0645 1 1
0.0545 0.5 0.5
0.0443 0.5 0.5
0.0748 0.7357 0.7208
0.0648 0.6548 1
0.005 0.2901 0.5
0.0328 0.6783 1
0.0336 1 1
0.0427 1 1
0.0301 0.5578 1
0.0333 0.2897 1
0.0604 0.7475 1
0.0354 1 1
0.0502 1 1
0.0082 1 1
0.0306 0.3642 1
0.0182 1 1
0.0097 0.2747 0.5
0.0513 1 1
0.0308 0.3713 1
0.005 1 1
0.01 0.5461 1
0.0652 1 1
0.1651 0.2576 1
0.0539 0.5 0.5
0.0763 0.5 0.5
0.0378 1 1
0.005 0.5 0.5
0.047 0.4756 1
0.0337 0.3141 0.7152
0.0378 0.3776 1
0.0542 0.5 0.5
0.0763 0.5 0.5
0.0405 0.9596 1
0.043 0.4691 1
0.1518 0.2829 1
0.0457 0.5 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.7.4180 (Trypanosoma brucei), Fatty acid elongase
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