Detailed view for Tb927.8.690

Basic information

TDR Targets ID: 13573
Trypanosoma brucei, peptidyl-prolyl cis-trans isomerase/rotamase, putative

Source Database / ID:  TriTrypDB  GeneDB

pI: 6.4672 | Length (AA): 115 | MW (Da): 12498 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00639   PPIC-type PPIASE domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0016853   isomerase activity  
GO:0003755   peptidyl-prolyl cis-trans isomerase activity  
GO:0006457   protein folding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 115 2lj4 (A) 4 118 99.00 0 1 2.1969 -1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 2LJ4:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_128367)

Species Accession Gene Product
Arabidopsis thaliana AT2G18040   peptidyl-prolyl cis-trans isomerase Pin1
Babesia bovis BBOV_IV000920   peptidyl-prolyl cis-trans isomerase, putative
Brugia malayi Bm1_02445   Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1
Candida albicans CaO19.5196   peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t
Candida albicans CaO19.12663   peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t
Caenorhabditis elegans CELE_Y110A2AL.13   Protein PINN-1
Dictyostelium discoideum DDB_G0268618   hypothetical protein
Drosophila melanogaster Dmel_CG17051   dodo
Echinococcus granulosus EgrG_000478800   expressed protein
Entamoeba histolytica EHI_188070   peptidyl-prolyl cis-trans isomerase, putative
Echinococcus multilocularis EmuJ_000478800   expressed protein
Homo sapiens ENSG00000127445   peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Leishmania braziliensis LbrM.07.1080   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative
Leishmania donovani LdBPK_071180.1   peptidyl-prolyl cis-trans isomerase/rotamase, putative
Leishmania infantum LinJ.07.1180   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative
Leishmania major LmjF.07.1030   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative
Leishmania mexicana LmxM.07.1030   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative
Loa Loa (eye worm) LOAG_06824   Pin1-type peptidyl-prolyl cis-trans isomerase
Mus musculus ENSMUSG00000032171   protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
Mus musculus ENSMUSG00000074997   protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1, retrogene 1
Neospora caninum NCLIV_027540   peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative
Oryza sativa 9266162   Os04g0118500
Saccharomyces cerevisiae YJR017C   peptidylprolyl isomerase ESS1
Schistosoma japonicum Sjp_0055700   ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative
Schistosoma mansoni Smp_162890   rotamase
Schmidtea mediterranea mk4.000228.02   Putative rotamase
Trypanosoma brucei gambiense Tbg972.8.300   peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative
Trypanosoma brucei Tb927.8.690   peptidyl-prolyl cis-trans isomerase/rotamase, putative
Trypanosoma congolense TcIL3000_8_240   peptidyl-prolyl cis-trans isomerase/rotamase, putative
Trypanosoma cruzi TcCLB.509611.20   peptidyl-prolyl cis-trans isomerase
Trypanosoma cruzi TcCLB.508567.70   peptidyl-prolyl cis-trans isomerase
Toxoplasma gondii TGME49_258930   peptidylprolyl isomerase
Theileria parva TP01_0114   peptidyl-prolyl cis-trans isomerase, putative
Trichomonas vaginalis TVAG_420360   rotamase, putative
Trichomonas vaginalis TVAG_325610   rotamase, putative
Trichomonas vaginalis TVAG_102340   conserved hypothetical protein

Essentiality

Tb927.8.690 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.690 this record Trypanosoma brucei significant gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.690 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.690 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.690 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
YJR017C Saccharomyces cerevisiae inviable yeastgenome
TGME49_258930 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) increased (PATO:0000470) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6


Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0039 0.4942 1
0.0099 0.5616 0.5
0.0034 0.2607 0
0.0141 0.9729 1
0.0204 0.2767 1
0.0144625 0.855192 1
0.0102 0.4712 1
0.0034 0.4608 0.5505
0.0131 0.2731 1
0.0039 0.9622 0.5
0.0038 0.3281 1
0.0101 0.5349 1
0.0039 0.4222 1
0.0039 0.948 0.5
0.0039 0.9608 1
0.0039 0.3533 0.5505
0.0032 0.2762 1
0.0032 0.3762 1
0.0136 0.4324 1
0.0032 0.2531 1
0.0072 0.9732 1
0.0039 0.9638 0.5
0.0128 0.2504 1
0.0032 0.96 0.5
0.013 0.8442 1
0.0132 0.8561 1
0.0027 0.5132 0.5
0.0039 0.3044 0.3044
0.0125 0.9722 1
0.0034 0.3677 1
0.0039 0.6311 0.9821
0.0039 0.4027 0.1754
0.0065 0.3125 1
0.0038 0.9629 0.5
0.0097 0.3128 1
0.0099 0.4983 1
0.0067 0.9415 0.5
0.0039 0.3677 1
0.0097 0.3963 0.5
0.0193 0.9739 1
0.0103 0.5416 1
0.0039 0.4442 1
0.0065 0.3105 1
0.0128 0.2504 1
0.0065 0.9517 0.5
0.0033 0.9662 1
0.0069 0.537 0.537
0.0039 0.9662 1
0.0173 0.7043 0.5
0.0128 0.2504 1
0.0064 0.6978 0.6978
0.0039 0.3044 0.3044
0.0352 0.9697 1
0.0036 0.4942 0.5
0.0036 0.2837 0.2046
0.0032 0.6311 1
0.0169 0.3935 1
0.0066 0.9662 1
0.0037 0.7087 1
0.0039 0.2618 0.8387
0.0039 0.3301 1
0.007 0.6437 1
0.015 0.9662 1
0.0039 0.4072 0.6136
0.0039 0.4849 0.6457
0.0508 0.9758 1
0.0024 0.6311 0.9679
0.0032 0.6311 1
0.0039 0.2594 0
0.0466 0.9757 1
0.0039 0.9623 0.5
0.0472 0.9662 1
0.03 0.3395 1
0.0039 0.2607 0.5
0.0039 0.4942 0.5
0.0097 0.9639 1
0.0032 0.9661 1
0.0032 0.4222 1
0.0172 0.5074 1
0.0065 0.9518 0.5
0.0099 0.3769 0.5
0.0064 0.6112 0
0.0507 0.975 1
0.0137 0.676 0.5
0.0144625 0.855192 1
0.0036 0.3033 1
0.021 0.975 1
0.0105 0.9714 1
0.0102 0.4712 1
0.0039 0.5581 1
0.0467 0.9753 1
0.0493 0.9757 1
0.0039 0.6311 1
0.0039 0.9662 0.9679
0.0069 0.537 0.537
0.0033 0.4222 1
0.0039 0.5321 0.5
0.0039 0.3872 0.3872
0.0099 0.6139 1
0.0487 0.619 1
0.0038 0.3315 0.2857
0.0173 0.7043 0.5
0.0039 0.4837 1
0.0097 0.546 0.5
0.0039 0.9702 1
0.00928024 0.984571 1
0.0102 0.9713 1
0.0037 0.9662 1
0.0507 0.975 1
0.0039 0.3199 1
0.0453 0.9739 1
0.0036 0.6311 1
0.0039 0.3077 0.5
0.004 0.9673 1
0.0039 0.4187 0.4187
0.0223 0.2546 1
0.0043 0.973 1
0.0038 0.9629 0.5
0.0032 0.9662 1
0.0167 0.9662 1
0.0101 0.5349 1
0.0039 0.4442 1
0.0098 0.5385 1
0.0234 0.2654 1
0.0039 0.9678 1
0.0163 0.3997 1
0.0102 0.9743 1
0.007 0.6437 1
0.0039 0.9637 0.5
0.0039 0.9662 1
0.0032 0.8904 1
0.0065 0.6214 0.6214
0.0033 0.9662 0.9679
0.0034 0.9662 0.9679
0.0106 0.5175 0.5
0.0032 0.972 1
0.0039 0.862 0.8373
0.0034 0.4608 0.5505
0.0039 0.9636 0.5
0.0039 0.9628 1
0.0033 0.4187 0.4187
0.0487 0.9741 1
0.0039 0.9553 0.9553
0.0039 0.8698 1
0.0032 0.9661 1
0.0105 0.9713 1
0.0039 0.9758 1
0.0101 0.5349 1
0.0039 0.6311 1
0.0098 0.3563 0.5
0.03 0.3395 1
0.0088 0.9454 1
0.0072 0.4654 1
0.0106 0.407 0.5
0.0032 0.3805 0.5
0.0015 0.9662 1
0.0065 0.9689 1
0.0209 0.4996 1
0.0457 0.9747 1
0.0039 0.9541 1
0.0066 0.7327 0
0.0144625 0.855192 1
0.0039 0.5658 1
0.0037 0.6311 1
0.0039 0.4348 0.4348
0.0039 0.2515 0.2515
0.0032 0.6311 1
0.0032 0.9662 1
0.0039 0.3858 1
0.0129 0.849 1
0.0149 0.3049 1
0.014 0.7469 1
0.0326 0.7325 1
0.015 0.9758 1
0.0511 0.9662 1
0.0542 0.9754 1
0.0039 0.8333 1
0.0299 0.3449 1
0.0033 0.9662 1
0.0182 0.2646 1
0.0448 0.9757 1
0.0039 0.5321 0.5
0.0039 0.6311 1
0.0039 0.5658 1
0.0057 0.9742 1
0.01 0.5231 1
0.0097 0.4056 0.5
0.0033 0.4788 1
0.0039 0.2607 0.5
0.0038 0.3737 0.5
0.0034 0.9662 1
0.0104 0.6869 1
0.0033 0.4348 0.4348
0.0144 0.9754 1
0.004 0.9673 1
0.0102 0.3093 1
0.0039 0.9662 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.8.690 (Trypanosoma brucei), peptidyl-prolyl cis-trans isomerase/rotamase, putative
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