Detailed view for PF3D7_1029600

Basic information

TDR Targets ID: 1363
Plasmodium falciparum, adenosine deaminase

Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 5.4334 | Length (AA): 367 | MW (Da): 42466 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00962   Adenosine/AMP deaminase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005575   cellular_component  
GO:0019239   deaminase activity  
GO:0004000   adenosine deaminase activity  
GO:0009168   purine ribonucleoside monophosphate biosynthetic process  

Metabolic Pathways

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 365 2a3l (A) 360 790 18.00 0 1 0.85 0.32
10 367 2amx (A) 18 376 64.00 0 1 1.96 -2.59
9 367 2amx (A) 18 376 64.00 0 1 1.8895 -1.81
10 367 2pgf (A) 5 363 73.00 0 1 1.99778 -2.02

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

  • 2AMX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2PGF:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2PGR:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 2QVN:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3EWC:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
  • 3EWD:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, merozoite, sporozoite, early ring, early schizont, early trophozoite, late ring, late schizont, late trophozoite, Oocyst, Ring. Otto TD PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Female Gametocyte, Male Gametocyte. Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Sporozoite. Zanghi G
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.

Orthologs

Ortholog group members (OG5_127245)

Species Accession Gene Product
Arabidopsis thaliana AT4G04880   adenosine deaminase-like protein
Babesia bovis BBOV_I001470   adenosine deaminase, putative
Brugia malayi Bm1_18590   Adenosine/AMP deaminase family protein
Candida albicans CaO19.9791   similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase
Candida albicans CaO19.2251   similar to S. cerevisiae AAH1 (YNL141W) adenine aminohydrolase
Caenorhabditis elegans CELE_C06G3.5   Protein C06G3.5, isoform B
Caenorhabditis elegans CELE_C44B7.12   Protein C44B7.12
Dictyostelium discoideum DDB_G0287371   adenosine deaminase
Drosophila melanogaster Dmel_CG11994   Adenosine deaminase
Escherichia coli b1623   adenosine deaminase
Echinococcus granulosus EgrG_000536400   adenosine deaminase
Entamoeba histolytica EHI_014320   adenosine deaminase, putative
Entamoeba histolytica EHI_005040   adenosine deaminase, putative
Echinococcus multilocularis EmuJ_000536400   adenosine deaminase
Homo sapiens ENSG00000196839   adenosine deaminase
Homo sapiens ENSG00000168803   adenosine deaminase-like
Leishmania braziliensis LbrM.34.2090   adenine aminohydrolase
Leishmania donovani LdBPK_352200.1   adenine aminohydrolase
Leishmania infantum LinJ.35.2200   adenine aminohydrolase
Leishmania major LmjF.35.2160   adenine aminohydrolase
Leishmania mexicana LmxM.34.2160   adenine aminohydrolase
Loa Loa (eye worm) LOAG_13491   hypothetical protein
Loa Loa (eye worm) LOAG_09631   hypothetical protein
Loa Loa (eye worm) LOAG_15299   hypothetical protein
Loa Loa (eye worm) LOAG_12299   hypothetical protein
Loa Loa (eye worm) LOAG_15552   hypothetical protein
Mycobacterium leprae ML0700   Probable adenosine deaminase Add (ADENOSINE AMINOHYDROLASE)
Mus musculus ENSMUSG00000017697   adenosine deaminase
Mus musculus ENSMUSG00000027259   adenosine deaminase-like
Mycobacterium tuberculosis Rv3313c   Probable adenosine deaminase Add (adenosine aminohydrolase)
Mycobacterium ulcerans MUL_1364   adenosine deaminase
Neospora caninum NCLIV_052400   adenosine/AMP deaminase domain containing protein, putative
Neospora caninum NCLIV_019950   Adenosine deaminase (EC 3.5.4.4), related
Oryza sativa 4344179   Os07g0661000
Onchocerca volvulus OVOC3922   Adenosine deaminase homolog
Plasmodium berghei PBANKA_0513600   adenosine deaminase, putative
Plasmodium falciparum PF3D7_1029600   adenosine deaminase
Plasmodium knowlesi PKNH_0614300   adenosine deaminase, putative
Plasmodium vivax PVX_111245   adenosine deaminase, putative
Plasmodium yoelii PY02076   adenosine deaminase
Saccharomyces cerevisiae YNL141W   adenine deaminase
Schistosoma japonicum Sjp_0056550   ko:K01488 adenosine deaminase [EC3.5.4.4], putative
Schistosoma japonicum Sjp_0051070   ko:K01488 adenosine deaminase [EC3.5.4.4], putative
Schistosoma mansoni Smp_140430   adenosine deaminase-related
Schistosoma mansoni Smp_035700   adenosine deaminase
Schmidtea mediterranea mk4.000517.09  
Schmidtea mediterranea mk4.001281.03  
Schmidtea mediterranea mk4.000517.08  
Schmidtea mediterranea mk4.003471.00  
Schmidtea mediterranea mk4.001179.00   Putative adenosine deaminase
Toxoplasma gondii TGME49_205720   Adenosine/AMP deaminase domain-containing protein
Toxoplasma gondii TGME49_215480   Adenosine/AMP deaminase domain-containing protein
Treponema pallidum TP0045   adenosine deaminase
Trichomonas vaginalis TVAG_416510   adenosine deaminase, putative
Trichomonas vaginalis TVAG_430670   adenosine deaminase, putative

Essentiality

PF3D7_1029600 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b1623 Escherichia coli non-essential goodall
CELE_C06G3.5 Caenorhabditis elegans embryonic lethal wormbase
PBANKA_0513600 Plasmodium berghei Dispensable plasmo
TGME49_215480 Toxoplasma gondii Probably non-essential sidik
TGME49_205720 Toxoplasma gondii Probably non-essential sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) lethal (sensu genetics) (PATO:0000718) multi-cellular organism (CARO:0000012) bloodstream stage (PLO:0040) in vivo inhibition (TDR:00016) Plasmodium falciparum 40483   532381   532382  
Annotator: saralph@unimelb.edu.au. Comment: Drug: deoxycoformycin. . References: 10639753 15576366

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 1


Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens adenosine deaminase Compounds References
Mus musculus adenosine deaminase Compounds References
Bos taurus Adenosine deaminase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.3185 0.2873 1
0.0277 0.7929 1
0.347 1 1
0.5055 1 1
0.1115 0.4684 0.5
0.4495 0.8655 1
0.0258 0.6533 1
0.0104 0.5348 1
0.0719 1 1
0.0368 1 1
0.3185 0.2873 1
0.0388 1 1
0.0383 0.4665 0.9745
0.0276 1 0.5
0.5146 1 1
0.6601 1 1
0.0644 1 1
0.137 0.9224 0.9217
0.0284 1 1
0.0907 0.2943 1
0.3387 1 1
0.0174 0.5104 0
0.0965 1 1
0.0544 1 1
0.0104 0.5901 1
0.0247 1 0.5
0.3418 1 1
0.0174 0.4963 1
0.0575 0.6578 1
0.01 0.2568 0.9214
0.0073 1 0.5
0.0517 1 0.5
0.0554 1 0.5
0.0269 0.7423 0.7414
0.2021 1 1
0.4291 1 1
0.297 1 1
0.6959 1 1
0.8655 1 1
0.8106 1 1
0.0085 1 0.5
0.0171 0.602 1
0.0907 0.2943 1
0.0137 1 1
0.7929 1 1
0.3397 1 1
0.051 1 0.5
0.0712 0.4088 0.4067
0.0085 0.9602 1
0.4107 1 1
0.0258 0.8056 1
0.0172 0.4952 1
0.0388 1 0.5
0.2162 1 1
0.0137 0.4169 1
0.0137 1 1
0.6565 1 1
0.0104 1 0.5
0.3185 0.2873 1
0.1416 0.466 0.4605
0.5243 1 1
0.0084 1 0.5
0.0907 0.2943 1
0.7565 1 1
0.4982 1 1
0.4506 1 1
0.3196 1 1
0.0086 0.4803 0
0.2848 0.3419 1
0.029 1 1
0.0655 1 0.5
0.0199 0.5521 1
0.0844 1 1
0.0368 1 0.5
0.0277 0.5152 1
0.1851 0.6362 1
0.429 1 1
0.0104 0.6445 1
0.0898 1 1
0.3185 0.2873 1
0.0431 1 1
0.0344 0.3172 0.2903
0.0258 0.8056 1
0.3185 0.2873 1
0.0907 0.295 1
0.0104 0.4272 1
0.0359 1 1
0.4626 1 1
0.0366 1 0.5
0.3185 0.2873 1
0.0113854 0.265169 0.233375
0.4439 1 1
0.4092 1 1
0.0104 0.6801 1
0.0723 0.2561 1
0.4291 1 1
0.0663 0.3595 1
0.0095 1 1
0.0373 0.6758 1
0.0272 1 1
0.0173 0.3558 0.6757
0.0338 0.2713 1
0.5146 1 1
0.3185 0.2873 1
0.1716 1 1
0.6654 1 1
0.0388 1 0.5
0.5146 1 1
0.0536 0.5596 0.5
0.0564 0.686 1
0.4872 0.4057 1
0.052 1 0.5
0.0104 1 0.5
0.0273 0.2864 1
0.0174 0.345 1
0.0344 0.2802 0.5702
0.0173 0.4742 1
0.0261 1 0.5
0.5052 1 1
0.3185 0.2873 1
0.3185 0.2873 1
0.7933 1 1
0.7983 1 1
0.277 1 1
0.0104 0.4257 1
0.0196 0.6278 0.577
0.4097 1 1
0.0176 0.5004 1
0.3185 0.2873 1
0.0094 0.2518 1
0.0884 0.4668 0.5
0.5554 1 1
0.0275 0.3297 0.2698
0.0805 0.3745 1
0.4655 1 1
0.0565 1 0.5
0.3185 0.2873 1
0.0104 1 1
0.0936 0.5 0.5
0.0065 1 0.5
0.3185 0.2873 1
0.0356 1 1
0.7565 1 1
0.3688 1 1
0.02 0.5535 1
0.0823 1 0.5
0.0269 0.9447 1
0.0359 1 1
0.026 0.355 1
0.0349 0.336 1
0.0137 1 1
0.017 1 1
0.3566 1 1
0.0086 0.284 0.5889
0.0465 1 1
0.4495 0.8655 1
0.0344 0.2802 0.5702
0.0802 1 1
0.5554 1 1
0.3185 0.2873 1
0.0137 1 1
0.3253 1 1
0.0104 1 0.5
0.0581 1 1
0.0168 1 1
0.4107 1 1
0.3185 0.2873 1
0.6565 1 1
0.0107 1 1
0.0222 1 1
0.0907 0.295 1
0.4878 1 1
0.0171 0.6829 1
0.2035 1 1
0.0092 0.7598 1
0.429 1 1
0.6989 0.3855 1
0.1135 1 1
0.5752 1 1
0.0582 1 0.5
0.5554 1 1
0.0174 0.3836 1
0.017 1 1
0.0349 0.3325 1
0.0399 0.8612 0.8612
0.0355 0.2732 1
0.0104 1 1
0.0083 0.5292 0
0.0433 1 1
0.0084 0.4356 1
0.2848 0.3419 1
0.7933 1 1
0.0547 1 1
0.3978 1 1
0.0554 1 1
0.0197 0.5367 0.5367
0.2035 1 1
0.0137 0.2959 1
0.0467 1 0.5
0.3722 1 1
0.0163 1 1
0.0459 0.2648 0.323
0.0257 0.2544 1
0.0271 1 1
0.0373 0.6758 1
0.0354 1 1
0.0089 0.5396 1
0.0531 1 1
0.4092 1 1
0.0089 1 1
0.0174 0.345 1
0.0261 0.3061 0.6189
0.0544 1 0.5
0.0111 0.2568 1
0.0171 0.6829 1
0.0169 0.4851 1
0.3253 1 1
0.0256 0.6664 0.5
0.0195 0.2866 1
0.0455 1 1
0.4107 1 1
0.5071 1 1
0.0104 0.5104 0
0.3185 0.2873 1
0.0712 0.4088 0.4067
0.0084 1 0.5
0.3681 1 1
0.4821 1 1
0.3185 0.2873 1
0.0355 0.258 0.258
0.0269 0.9447 1
0.0661 0.4103 1
0.1396 1 1
0.4655 1 1
0.4655 1 1
0.0171 0.5716 1
0.0269 0.7423 0.7414
0.028 0.3824 0.6751
0.0084 0.5781 0.5578
0.0104 1 0.5
0.0376 1 1
0.009 0.2803 1
0.3827 0.7658 1
0.3323 1 1
0.0389 0.2695 0.9553
0.0496 0.284 1
0.1166 1 1
0.5055 1 1
0.0274 1 1
0.026 0.961 0.5
0.0104 0.4423 1
0.0107 1 1
0.0463 1 0.5
0.0375 0.2551 0.5
0.0167 0.439 1
0.0998 1 1
0.0368 1 1
0.0477 1 0.5
0.0084 0.5606 0.5
0.137 0.9224 0.9217
0.0467 0.2575 0.4379
0.0274 1 1
0.0431 1 1
0.0545 1 1
0.4982 1 1
0.028 0.3824 0.6751
0.028 1 0.5
0.0196 0.6278 0.577
0.5482 1 1
0.0359 1 1
0.1339 1 1
0.0378 0.4249 1
0.0103 1 1
0.0179 0.3411 1
0.0137 1 1
0.017 1 0.5
0.2848 0.3419 1
0.0539 1 0.5
0.0181 0.3232 0.3232
0.0104 0.54 0.5
0.0261 0.519 1
0.0172 0.2726 0.5
0.00911339 0.298831 0.270611
0.029 1 1
0.0172 1 1
0.0201 0.271 0.56
0.6657 1 1
0.0907 0.2946 1
0.0104 0.2696 0
0.0907 0.295 1
0.7202 1 1
0.0169 0.4538 0
0.0084 1 1
0.5711 1 1
0.0179 0.2605 1
0.0175 1 1
0.0564 0.686 1
0.4097 1 1
0.0104 1 0.5
0.2722 1 1
0.0465 1 1
0.0663 0.3595 1
0.0284 1 0.5
0.02 0.5535 1
0.0092111 1 0.5
0.0104 1 0.5
0.0171 1 1
0.4821 1 1
0.0259 1 0.5
0.0469 0.2511 0.6023
0.017 1 1
0.1851 0.6362 1
0.0113854 0.265169 0.233375
0.0167 0.305 1
0.017 1 1
0.0268 0.2688 1
0.2053 1 1
0.7811 1 1
0.5075 1 1
0.0724 1 1
0.0174 0.345 1
0.0445 1 1
0.0359 1 1
0.0337 0.2732 1
0.4655 1 1
0.0095 0.4158 0.9191
0.0907 0.295 1
0.0137 1 1
0.6484 1 1
0.0338 0.2713 1
0.0429 0.2958 1
0.0137 0.3391 0.8878
0.0104 1 1
0.4097 1 1
0.0104 0.2917 1
0.5055 1 1
0.0556 0.681 1
0.0171 0.3337 0
0.631 1 1
0.0269 1 0.5
0.0845 0.3362 1
0.7026 1 1
0.0907 0.295 1
0.0575 0.6843 1
0.009 1 0.5
0.017 1 1
0.5502 1 1
0.6484 1 1
0.1396 1 1
0.0348 1 1
0.0528 0.5067 1
0.6823 1 1
0.4732 1 1
0.0435 0.2913 0.2642
0.4471 1 1
0.0261 0.648 0.5835
0.2297 1 1
0.0104 0.3648 1
0.0195 0.8339 1
0.3185 0.2873 1
0.0085 0.72 0.5
0.4097 1 1
0.0137 1 1
0.0391 1 1
0.0532 0.4619 1
0.0104 0.4292 1
0.0536 1 0.5
0.3397 1 1
0.3185 0.2873 1
0.0521 0.3896 1
0.4626 1 1
0.6565 1 1
0.0201 0.6826 1
0.0137 1 1
0.0654 1 1
0.0464 0.2819 0.2587
0.6066 0.886 1
0.3185 0.2873 1
0.0723 0.2561 1
0.0661 0.4103 1
0.4097 1 1
0.0104 0.8628 1
0.0104 1 1
0.5055 1 1
0.0443 0.2633 1
0.0575 0.6578 1
0.6484 1 1
0.0137 1 1
0.0642 0.9269 1
0.0176 0.4952 1
0.0174 0.345 1
0.0544 1 1
0.0936 0.5 0.5
0.0995 0.5 0.5
0.3827 0.7658 1
0.3185 0.2873 1
0.0262 0.2546 0.2546
0.0085 0.3609 0.5
0.0541 1 0.5
0.5277 1 1
0.3706 1 1
0.5229 1 1
0.0216 1 1
0.0104 1 0.5
0.0185 1 0.5
0.0889 0.9072 1
0.0262 0.7034 1
0.0166 1 1
0.5986 1 1
0.0089 1 0.5
0.0104 1 0.5
0.0332 1 1
0.4626 1 1
0.0087 1 0.5
0.733 1 1
0.4495 0.8655 1
0.4471 1 1
0.1355 0.977 0
0.0193 0.5339 0.5699
0.0104 1 0.5
0.0823 1 0.5
0.297 1 1
0.0661 0.4103 1
0.0137 1 1
0.0907 0.295 1
0.094 0.3075 1
0.0536 0.5596 0.5
0.9135 1 1
0.1826 1 1
0.034 0.2509 0.2463
0.0374 1 1
0.0255 0.3777 0.9537
0.0173 1 0.5
0.0344 0.2802 0.5702
0.3185 0.2873 1
0.0903 1 1
0.1531 1 1
0.0269 0.5339 1
0.563 1 1
0.0463 1 0.5
0.3185 0.2873 1
0.6989 0.3855 1
0.0433 1 1
0.4716 1 1
0.0192 0.5674 0.521
0.0805 0.3745 1
0.0907 0.2943 1
0.0719 1 1
0.0177 0.5996 1
0.0166 0.5004 1
0.1826 1 1
0.0137 1 1
0.0214 0.654 1
0.3408 1 1
0.0178 1 1
0.0088 0.2839 1
0.0998 1 1
0.0762 0.6389 1
0.0477 1 1
0.0327 1 1
0.5243 1 1
0.0086 0.4908 1
0.948 1 1
0.0261 0.648 0.5835
0.0346 0.341 0.8936
0.0284 0.5 0.5
0.027 1 0.5
0.4482 1 1
0.0104 0.2877 0.5
0.0892 0.5 0.5
0.0845 0.3362 1
0.3253 1 1
0.3827 0.7658 1
0.2772 1 1
0.108 1 1
0.029 1 1
0.0344 0.2802 0.5702
0.0641 1 1
0.0526 1 1
0.0907 0.295 1
0.0086 0.4925 0
0.0672 0.8081 1
0.0576 1 1
0.0207 0.4568 0.4472
0.0575 0.6578 1
0.0104 0.2528 1
0.0166 1 1
0.4097 1 1
0.0903 1 1
0.0085 1 0.5
0.5273 1 1
0.0388 0.5 0.5
0.0261 1 0.5
0.0104 1 0.5
0.3185 0.2873 1
0.0172 0.5241 1
0.0431 1 1
0.0265 0.6994 1
0.6484 1 1
0.0098 1 0.5
0.0091 0.2608 0.2608
0.2848 0.3419 1
0.0137 1 1
0.4626 1 1
0.3827 0.7658 1
0.0491 1 0.5
0.5055 1 1
0.0287 1 1
0.4471 1 1
0.4097 1 1
0.0268 0.2688 1
0.0174 0.2506 1
0.3478 1 1
0.1046 1 1
0.6484 1 1
0.0907 0.295 1
0.0264 1 1
0.0137 0.2729 1
0.5393 1 1
0.0642 0.9269 1
0.0085 0.4929 0
0.0091 0.596 0
0.0532 0.4619 1
0.0472 0.5018 1
0.1542 1 1
0.009 0.2605 1
0.2617 1 1
0.2263 1 1
0.02 0.2991 0
0.6253 1 1
0.0104 0.2675 0.5
0.0104 1 0.5
0.0171 0.4784 1
0.0171 1 0.5
0.0085 0.4929 0
0.5693 1 1
0.0269 1 0.5
0.3827 0.7658 1
0.0275 0.3297 0.2698
0.058 0.3407 1
0.2846 1 1
0.5071 1 1
0.0169 1 1
0.3185 0.2873 1
0.0531 1 1
0.0264 1 0.5
0.44 1 1
0.0378 0.4249 1
0.0544 1 0.5
0.0561 1 1
0.0378 1 1
0.3185 0.2873 1
0.0137 1 1
0.2809 1 1
0.0261 1 0.5
0.0137 1 1
0.3348 1 1
0.0266 1 1
0.446 1 1
0.733 1 1
0.0257 0.3158 1
0.0084 0.5104 0
0.0347 0.2815 0.2795
0.0496 0.284 1
0.0521 0.3896 1
0.0907 0.2943 1
0.0538 0.5317 0.5
0.0113854 0.265169 0.233375
0.0177 0.5996 1
0.0498 1 1
0.5365 1 1
0.429 1 1
0.0661 0.4103 1
0.5215 1 1
0.4471 1 1
0.0085 1 0.5
0.0178 1 1
0.3185 0.2873 1
0.2141 1 1
0.0173 0.4742 1
0.0086 0.4112 1
0.0349 0.345 1
0.2561 1 1
0.0262 0.3224 1
0.009 0.2605 1
0.0085 0.4097 0
0.0831 1 1
0.0712 0.4088 0.4067
0.026 1 0.5
0.0179 0.2605 1
0.0173 1 1
0.0086 0.4112 1
0.0623 1 1
0.0445 1 1
0.0188 0.5074 1
0.174 1 1
0.4291 1 1
0.5201 1 1
0.6484 1 1
0.0348 0.4895 0.5333
0.4158 1 1
0.0344 1 1

Assayability

Assay information

  • Assay for Adenosine Deaminase (3.5.4.4 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.
  • BRENDA Assay
  • An enzyme with this EC number or name or sequence has been assayed in Plasmodium falciparum ( 1 )

Reagent availability

  • Pviv005676AAA;
  • Type Source Notes
    soluble recombinant protein Structural Genomics for Pathogenic Protozoa (SGPP) Pviv005676; Recombinant protein: full-length; Source: P vivax; Adenosine deaminase ; Identifier: Pv111245

Bibliographic References

29 literature references were collected for this gene.

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Gene identifier PF3D7_1029600 (Plasmodium falciparum), adenosine deaminase
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