pI: 4.876 |
Length (AA): 367 |
MW (Da): 41999 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 367 | 3dyh (A) | 1 | 367 | 99.99 | 0 | 1 | 2.2443 | -1.72 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
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Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127590)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G17190 | farnesyl diphosphate synthase 2 |
Arabidopsis thaliana | AT5G47770 | farnesyl diphosphate synthase 1 |
Babesia bovis | BBOV_I000120 | farnesyl pyrophosphate synthetase, putative |
Brugia malayi | Bm1_54695 | Polyprenyl synthetase family protein |
Candida albicans | CaO19.11967 | similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) |
Candida albicans | CaO19.4491 | similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) |
Caenorhabditis elegans | CELE_R06C1.2 | Protein FDPS-1 |
Cryptosporidium hominis | Chro.40285 | farnesyl pyrophosphate synthase |
Cryptosporidium parvum | cgd4_2550 | putative farnesyl pyrophosphate synthase |
Dictyostelium discoideum | DDB_G0268742 | hypothetical protein |
Dictyostelium discoideum | DDB_G0278735 | FDP synthase |
Dictyostelium discoideum | DDB_G0278823 | hypothetical protein |
Drosophila melanogaster | Dmel_CG12389 | Farnesyl pyrophosphate synthase |
Echinococcus granulosus | EgrG_001040000 | farnesyl pyrophosphate synthase |
Echinococcus multilocularis | EmuJ_001040000 | farnesyl pyrophosphate synthase |
Giardia lamblia | GL50803_6633 | Farnesyl diphosphate synthase |
Homo sapiens | ENSG00000160752 | farnesyl diphosphate synthase |
Leishmania braziliensis | LbrM.22.1240 | farnesyl pyrophosphate synthase |
Leishmania donovani | LdBPK_221210.1 | farnesyl pyrophosphate synthase |
Leishmania infantum | LinJ.22.1210 | farnesyl pyrophosphate synthase |
Leishmania major | LmjF.22.1360 | farnesyl pyrophosphate synthase |
Leishmania mexicana | LmxM.22.1360 | farnesyl pyrophosphate synthase, putative |
Loa Loa (eye worm) | LOAG_06272 | polyprenyl synthetase |
Mus musculus | ensembl-mmu:ENSMUSG00000059743 | farnesyl diphosphate synthetase |
Mycobacterium tuberculosis | Rv2173 | Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) |
Mycobacterium ulcerans | MUL_0373 | geranylgeranyl pyrophosphate synthase |
Mycobacterium ulcerans | MUL_3516 | geranylgeranyl pyrophosphate synthase |
Neospora caninum | NCLIV_048200 | hypothetical protein |
Oryza sativa | 4337261 | Os04g0657300 |
Oryza sativa | 4337260 | Os04g0657100 |
Oryza sativa | 4324245 | Os01g0703400 |
Oryza sativa | 4339489 | Os05g0543400 |
Plasmodium berghei | PBANKA_0919800 | geranylgeranyl pyrophosphate synthase, putative |
Plasmodium falciparum | PF3D7_1128400 | geranylgeranyl pyrophosphate synthase, putative |
Plasmodium knowlesi | PKNH_0926500 | geranylgeranyl pyrophosphate synthase, putative |
Plasmodium vivax | PVX_092040 | geranylgeranyl pyrophosphate synthase |
Plasmodium yoelii | PY05919 | farnesyl pyrophosphate synthase |
Saccharomyces cerevisiae | YJL167W | bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase |
Schistosoma japonicum | Sjp_0216390 | ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative |
Schistosoma mansoni | Smp_070710 | farnesyl pyrophosphate synthase |
Schmidtea mediterranea | mk4.033514.01 | |
Schmidtea mediterranea | mk4.003779.02 | Farnesyl pyrophosphate synthase |
Schmidtea mediterranea | mk4.025052.00 | |
Trypanosoma brucei gambiense | Tbg972.7.3690 | farnesyl pyrophosphate synthase, putative |
Trypanosoma brucei | Tb927.7.3360 | farnesyl pyrophosphate synthase |
Trypanosoma congolense | TcIL3000_7_2560 | farnesyl pyrophosphate synthase |
Trypanosoma cruzi | TcCLB.511823.70 | farnesyl pyrophosphate synthase |
Trypanosoma cruzi | TcCLB.508323.9 | farnesyl pyrophosphate synthase, putative |
Toxoplasma gondii | TGME49_224490 | polyprenyl synthetase superfamily protein |
Theileria parva | TP03_0857 | farnesyl pyrophosphate synthetase, putative |
Trichomonas vaginalis | TVAG_150090 | geranylgeranyl pyrophosphate synthase, putative |
Trichomonas vaginalis | TVAG_388030 | geranylgeranyl pyrophosphate synthase, putative |
Trichomonas vaginalis | TVAG_353270 | geranylgeranyl diphosphate synthase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.3360 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.3360 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.3360 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.3360 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_R06C1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R06C1.2 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_R06C1.2 | Caenorhabditis elegans | sterile | wormbase |
YJL167W | Saccharomyces cerevisiae | inviable | yeastgenome |
PBANKA_0919800 | Plasmodium berghei | Essential | plasmo |
TGME49_224490 | Toxoplasma gondii | Essentiality uncertain | sidik |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | decreased time (PATO:0000716) | single cell organism (CARO:0000064) | bloodstream stage (PLO:0040) | inferred from RNAi experiment (ECO:0000019) | Trypanosoma brucei brucei | No drug identifiers listed for this gene. |
Annotator: | ts4@sanger.ac.uk. | Comment: | *** KD was not complete, KD of procyclic cells caused cell death. | References: | 12618430 | |
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | single cell organism (CARO:0000064) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | Trypanosoma brucei brucei | No drug identifiers listed for this gene. |
Annotator: | ts4@sanger.ac.uk. | Comment: | . | References: | 12618430 | |
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | single cell organism (CARO:0000064) | bloodstream stage (PLO:0040) | in vivo inhibition (TDR:00016) | Trypanosoma brucei brucei | No drug identifiers listed for this gene. |
Annotator: | ts4@sanger.ac.uk. | Comment: | Drug: bisphosphontes. . | References: | 12618430 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.8
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Plasmodium falciparum | geranylgeranyl pyrophosphate synthase, putative | Compounds | References |
Trypanosoma cruzi | farnesyl pyrophosphate synthase | Compounds | References |
Leishmania donovani | farnesyl pyrophosphate synthase | Compounds | References |
Leishmania major | farnesyl pyrophosphate synthase | Compounds | References |
Trypanosoma cruzi | farnesyl pyrophosphate synthase, putative | Compounds | References |
Toxoplasma gondii | polyprenyl synthetase superfamily protein | Compounds | References |
Homo sapiens | farnesyl diphosphate synthase | Compounds | References |
Target | Type | Source | Notes |
---|---|---|---|
Tb927.7.3360 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Trypanosoma brucei ( 2 ) |
13 literature references were collected for this gene.