pI: 5.3467 |
Length (AA): 506 |
MW (Da): 57974 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
167 | 537 | 5k4b (A) | 172 | 537 | 29.00 | 0 | 1 | 1.008 | -0.56 |
509 | 559 | 5cwh (A) | 105 | 155 | 12.00 | 0 | 0.01 | 0.281371 | -0.8 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128265)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT4G20980 | eukaryotic translation initiation factor 3 subunit 7 |
Arabidopsis thaliana | AT5G44320 | translation initiation factor eIF-3 subunit 7 |
Babesia bovis | BBOV_III000500 | eukaryotic translation initiation factor 3 subunit 7, putative |
Brugia malayi | Bm1_03660 | translation initiation factor 3 subunit 7 |
Brugia malayi | Bm1_00085 | translation initiation factor 3 subunit 7 |
Brugia malayi | Bm1_19625 | eukaryotic translation initiation factor 3 subunit 7, putative |
Caenorhabditis elegans | CELE_R08D7.3 | Protein EIF-3.D |
Cryptosporidium hominis | Chro.20034 | eukaryotic translation initiation factor 3 subunit 7 |
Cryptosporidium parvum | cgd2_270 | translation initiation factor eIF-3 subunit 7 |
Dictyostelium discoideum | DDB_G0274627 | eIF-3 zeta |
Drosophila melanogaster | Dmel_CG4810 | CG4810 gene product from transcript CG4810-RA |
Drosophila melanogaster | Dmel_CG10161 | Eukaryotic initiation factor 3 p66 subunit |
Echinococcus granulosus | EgrG_001125000 | eukaryotic translation initiation factor 3 |
Echinococcus multilocularis | EmuJ_001125000 | eukaryotic translation initiation factor 3 |
Homo sapiens | ENSG00000100353 | eukaryotic translation initiation factor 3, subunit D |
Leishmania braziliensis | LbrM.30.3030 | eukaryotic translation initiation factor 3 subunit 7-like protein |
Leishmania donovani | LdBPK_303080.1 | eukaryotic translation initiation factor 3 subunit d |
Leishmania infantum | LinJ.30.3080 | eukaryotic translation initiation factor 3 subunit 7-like protein |
Leishmania mexicana | LmxM.29.3040 | eukaryotic translation initiation factor 3 subunit 7-like protein |
Loa Loa (eye worm) | LOAG_03764 | hypothetical protein |
Mus musculus | ENSMUSG00000016554 | eukaryotic translation initiation factor 3, subunit D |
Neospora caninum | NCLIV_012130 | Eukaryotic translation initiation factor 3 subunit 7-like protein, related |
Oryza sativa | 4339634 | Os05g0566500 |
Plasmodium berghei | PBANKA_1206100 | eukaryotic translation initiation factor 3 subunit D, putative |
Plasmodium falciparum | PF3D7_1007900 | eukaryotic translation initiation factor 3 subunit D, putative |
Plasmodium knowlesi | PKNH_0806900 | eukaryotic translation initiation factor 3 subunit D, putative |
Plasmodium vivax | PVX_094590 | eukaryotic translation initiation factor 3 subunit 7, putative |
Plasmodium yoelii | PY04269 | eukaryotic translation initiation factor 3 subunit 7 |
Schistosoma japonicum | Sjp_0300780 | ko:K03251 translation initiation factor eIF-3 subunit 7, putative |
Schistosoma mansoni | Smp_136290 | eukaryotictranslation initiation factor 3 subunit |
Schmidtea mediterranea | mk4.000946.00 | Eukaryotic translation initiation factor 3 subunit D |
Trypanosoma brucei gambiense | Tbg972.6.4180 | eukaryotic translation initiation factor 3 subunit 7-like protein, putative |
Trypanosoma brucei | Tb927.6.4370 | eukaryotic translation initiation factor 3 subunit d |
Trypanosoma congolense | TcIL3000_6_3790 | eukaryotic translation initiation factor 3 subunit d |
Trypanosoma cruzi | TcCLB.509065.160 | eukaryotic translation initiation factor 3 subunit d |
Trypanosoma cruzi | TcCLB.506943.160 | eukaryotic translation initiation factor 3 subunit 7 |
Toxoplasma gondii | TGME49_317720 | eukaryotic translation initiation factor 3 subunit 7, putative |
Theileria parva | TP03_0787 | eukaryotic translation initiation factor 3 subunit 7, putative |
Trichomonas vaginalis | TVAG_062640 | eukaryotic translation initiation factor 3 subunit, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.6.4370 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.6.4370 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.6.4370 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.6.4370 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_R08D7.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_R08D7.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_R08D7.3 | Caenorhabditis elegans | sterile | wormbase |
PBANKA_1206100 | Plasmodium berghei | Essential | plasmo |
TGME49_317720 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.