pI: 6.3107 |
Length (AA): 439 |
MW (Da): 47651 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
154 | 195 | 4qoy (E) | 122 | 163 | 55.00 | 0 | 1 | 0.928672 | -2 |
156 | 193 | 2eq8 (C) | 131 | 168 | 47.00 | 0.0012 | 1 | 0.86276 | -2.14 |
204 | 436 | 2ii3 (A) | 193 | 419 | 48.00 | 0 | 1 | 1.15195 | -0.7 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128117)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G06850 | dihydrolipoamide branched chain acyltransferase |
Babesia bovis | BBOV_II001300 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial precursor, putative |
Brugia malayi | Bm1_43910 | Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor |
Caenorhabditis elegans | CELE_ZK669.4 | Protein ZK669.4 |
Chlamydia trachomatis | CT_400 | dihydrolipoamide succinyltransferase |
Dictyostelium discoideum | DDB_G0281797 | branched-chain alpha-keto acid dehydrogenase E2 component |
Drosophila melanogaster | Dmel_CG5599 | CG5599 gene product from transcript CG5599-RA |
Escherichia coli | b0115 | pyruvate dehydrogenase, dihydrolipoyltransacetylase component E2 |
Homo sapiens | ENSG00000137992 | dihydrolipoamide branched chain transacylase E2 |
Leishmania braziliensis | LbrM.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania donovani | LdBPK_050180.1 | dihydrolipoamide branched chain transacylase, putative |
Leishmania infantum | LinJ.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania major | LmjF.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Leishmania mexicana | LmxM.05.0180 | dihydrolipoamide branched chain transacylase, putative |
Loa Loa (eye worm) | LOAG_15407 | hypothetical protein |
Loa Loa (eye worm) | LOAG_11004 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05887 | hypothetical protein |
Mus musculus | ENSMUSG00000000340 | dihydrolipoamide branched chain transacylase E2 |
Neospora caninum | NCLIV_010320 | dihydrolipoamide branched chain transacylase, E2 subunit, putative |
Oryza sativa | 4327289 | Os01g0314100 |
Plasmodium berghei | PBANKA_0402300 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium falciparum | PF3D7_0303700 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex |
Plasmodium knowlesi | PKNH_0839400 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium vivax | PVX_119310 | lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative |
Plasmodium yoelii | PY00503 | Plasmodium vivax PV1H14105_P |
Schmidtea mediterranea | mk4.029456.00 | |
Schmidtea mediterranea | mk4.021231.00 | |
Trypanosoma brucei gambiense | Tbg972.5.5850 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma brucei | Tb927.5.4330 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma congolense | TcIL3000_5_4970 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma cruzi | TcCLB.507601.70 | dihydrolipoamide branched chain transacylase, putative |
Trypanosoma cruzi | TcCLB.510351.90 | dihydrolipoamide branched chain transacylase, putative |
Toxoplasma gondii | TGME49_319920 | 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein |
Theileria parva | TP04_0457 | lipoamide transferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.5.4330 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0115 | Escherichia coli | essential | goodall |
CELE_ZK669.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
PBANKA_0402300 | Plasmodium berghei | Slow | plasmo |
TGME49_319920 | Toxoplasma gondii | Essentiality uncertain | sidik |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.2
12 literature references were collected for this gene.