pI: 5.1501 |
Length (AA): 185 |
MW (Da): 20718 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 185 | 3gp3 (A) | 1 | 204 | 31.00 | 0.0000002 | 1 | 1.1174 | 0.55 |
1 | 185 | 4ij5 (A) | 1 | 182 | 25.00 | 0 | 1 | 1.3914 | -0.83 |
2 | 185 | 1h2e (A) | 3 | 184 | 26.00 | 0 | 1 | 1.40319 | -0.77 |
3 | 106 | 5um0 (A) | 2 | 109 | 38.00 | 0.000033 | 0.67 | 0.754562 | 0.47 |
4 | 185 | 2a6p (A) | 8 | 179 | 20.00 | 0 | 0.97 | 1.24018 | -0.43 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_129378)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G04120 | phosphoglycerate mutase-like protein |
Arabidopsis thaliana | AT3G50520 | phosphoglycerate mutase |
Candida albicans | CaO19.13477 | similar to phosphoglycerate mutases |
Candida albicans | CaO19.6056 | similar to phosphoglycerate mutases |
Drosophila melanogaster | Dmel_CG7059 | CG7059 gene product from transcript CG7059-RA |
Drosophila melanogaster | Dmel_CG15874 | Phosphoglycerate mutase 5-2 |
Escherichia coli | b4395 | phosphatase |
Leishmania braziliensis | LbrM.08.0060 | phosphoglycerate mutase protein, putative |
Leishmania donovani | LdBPK_080060.1 | phosphoglycerate mutase protein, putative |
Leishmania infantum | LinJ.08.0060 | phosphoglycerate mutase protein, putative |
Leishmania major | LmjF.08.0060 | phosphoglycerate mutase protein, putative |
Leishmania mexicana | LmxM.08.0060 | phosphoglycerate mutase protein, putative |
Mycobacterium leprae | ML1452c | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) |
Mycobacterium tuberculosis | Rv2228c | Multifunctional protein. Has RNASE H, alpha-ribazole phosphatase, and acid phosphatase activities. |
Mycobacterium ulcerans | MUL_3691 | phosphoglycerate mutase |
Neospora caninum | NCLIV_034520 | Phosphoglycerate/bisphosphoglycerate mutase (EC 5.4.2.1), related |
Oryza sativa | 4349723 | Os11g0138600 |
Saccharomyces cerevisiae | YOR283W | phosphoglycerate mutase |
Trypanosoma brucei gambiense | Tbg972.5.5000 | phosphoglycerate mutase protein, putative |
Trypanosoma brucei | Tb927.5.3580 | phosphoglycerate mutase protein, putative |
Trypanosoma congolense | TcIL3000_0_40660 | phosphoglycerate mutase protein, putative |
Trypanosoma congolense | TcIL3000_5_4010 | phosphoglycerate mutase protein, putative |
Trypanosoma cruzi | TcCLB.511649.150 | phosphoglycerate mutase protein, putative |
Trypanosoma cruzi | TcCLB.507811.44 | phosphoglycerate mutase protein, putative |
Toxoplasma gondii | TGME49_273030 | phosphoglycerate mutase family protein |
Trichomonas vaginalis | TVAG_165570 | phosphoglycerate mutase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3580 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.5.3580 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b4395 | Escherichia coli | non-essential | goodall |
TGME49_273030 | Toxoplasma gondii | Probably non-essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | single cell organism (CARO:0000064) | bloodstream stage (PLO:0040) | inferred from RNAi experiment (ECO:0000019) | Trypanosoma brucei brucei | No drug identifiers listed for this gene. |
Annotator: | ts4@sanger.ac.uk. | Comment: | . | References: | 15955817 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Tbru015950; Recombinant protein: full-length; Source: T brucei; phosphoglycerate mutase protein, putative ; |
Target | Type | Source | Notes |
---|---|---|---|
Tb927.5.3580 | cloned gene | BRENDA | A gene with this EC number or name or sequence has been cloned from Trypanosoma brucei ( 1 ) |
4 literature references were collected for this gene.