pI: 7.604 |
Length (AA): 561 |
MW (Da): 62037 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 554 | 4e3x (A) | 21 | 562 | 44.00 | 0 | 1 | 1.48862 | -0.76 |
11 | 557 | 4jdc (A) | 3 | 543 | 44.00 | 0 | 1 | 1.54774 | -0.72 |
42 | 543 | 4oe6 (A) | 53 | 562 | 52.00 | 0 | 1 | 1.48053 | -0.55 |
52 | 542 | 1ag8 (A) | 22 | 494 | 23.00 | 0.00011 | 1 | 1.08632 | -0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128522)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_04205 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor |
Candida albicans | CaO19.3974 | delta-1-pyrroline-5-carboxylate dehydrogenase |
Candida albicans | CaO19.11457 | delta-1-pyrroline-5-carboxylate dehydrogenase |
Caenorhabditis elegans | CELE_F56D12.1 | Protein ALH-6, isoform D |
Dictyostelium discoideum | DDB_G0283293 | hypothetical protein |
Drosophila melanogaster | Dmel_CG7145 | delta-1-Pyrroline-5-carboxylate dehydrogenase 1 |
Escherichia coli | b1014 | fused DNA-binding transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase |
Homo sapiens | ENSG00000159423 | aldehyde dehydrogenase 4 family, member A1 |
Leishmania braziliensis | LbrM.03.0210 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Leishmania donovani | LdBPK_030190.1 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Leishmania infantum | LinJ.03.0190 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Leishmania major | LmjF.03.0200 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Leishmania mexicana | LmxM.03.0200 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Loa Loa (eye worm) | LOAG_07106 | delta-1-pyrroline-5-carboxylate dehydrogenase |
Mus musculus | ENSMUSG00000028737 | aldehyde dehydrogenase 4 family, member A1 |
Mycobacterium tuberculosis | Rv1187 | Probable pyrroline-5-carboxylate dehydrogenase RocA |
Mycobacterium ulcerans | MUL_0932 | pyrroline-5-carboxylate dehydrogenase, RocA |
Saccharomyces cerevisiae | YHR037W | 1-pyrroline-5-carboxylate dehydrogenase |
Schistosoma japonicum | Sjp_0107580 | expressed protein |
Schistosoma japonicum | Sjp_0203100 | ko:K00294 1-pyrroline-5-carboxylate dehydrogenase [EC1.5.1.12], putative |
Schistosoma mansoni | Smp_065060 | aldehyde dehydrogenase |
Schmidtea mediterranea | mk4.000753.03 | Putative aldehyde dehydrogenase |
Trypanosoma brucei gambiense | Tbg972.10.4060 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Trypanosoma brucei | Tb927.10.3210 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Trypanosoma congolense | TcIL3000_10_2660 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.510943.50 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.509351.10 | delta-1-pyrroline-5-carboxylate dehydrogenase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0539 | bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1208 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.3210 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.3210 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.3210 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.10.3210 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1014 | Escherichia coli | non-essential | goodall |
CELE_F56D12.1 | Caenorhabditis elegans | slow growth | wormbase |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Aldehyde dehydrogenase 1A1 | 501 aa | 27.2% | 453 aa | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase | 519 aa | 28.6% | 454 aa | Compounds | References |
Rattus norvegicus | Aldehyde dehydrogenase, cytosolic 1 | 501 aa | 26.9% | 454 aa | Compounds | References |
1 literature reference was collected for this gene.