pI: 7.2022 |
Length (AA): 374 |
MW (Da): 41971 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
10 | 371 | 1okg (A) | 10 | 368 | 45.00 | 0 | 1 | 1.48621 | -0.26 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_127129)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G16460 | thiosulfate/3-mercaptopyruvate sulfurtransferase 2 |
Brugia malayi | Bm1_51915 | Rhodanese-like domain containing protein |
Candida albicans | CaO19.1356 | similar to rat mercaptopyruvate sulfurtransferase (D50564, EC 2.8.1.2) and to S. cerevisiae YOR251C |
Caenorhabditis elegans | CELE_R186.6 | Protein MPST-7 |
Caenorhabditis elegans | CELE_H12D21.7 | Protein MPST-3, isoform B |
Caenorhabditis elegans | CELE_H12D21.4 | Protein MPST-2 |
Dictyostelium discoideum | DDB_G0291816 | hypothetical protein |
Escherichia coli | b1757 | molybdopterin synthase sulfurtransferase |
Escherichia coli | b2521 | 3-mercaptopyruvate sulfurtransferase |
Giardia lamblia | GL50803_10783 | Thiosulfate sulfurtransferase |
Homo sapiens | ENSG00000128311 | thiosulfate sulfurtransferase (rhodanese) |
Homo sapiens | ENSG00000128309 | mercaptopyruvate sulfurtransferase |
Leishmania braziliensis | LbrM.05.0970 | 3-mercaptopyruvate sulfurtransferase |
Leishmania donovani | LdBPK_050970.1 | 3-mercaptopyruvate sulfurtransferase |
Leishmania infantum | LinJ.05.0970 | 3-mercaptopyruvate sulfurtransferase |
Leishmania major | LmjF.05.0970 | 3-mercaptopyruvate sulfurtransferase |
Leishmania mexicana | LmxM.05.0970 | mercaptopyruvate sulfurtransferase |
Loa Loa (eye worm) | LOAG_07696 | hypothetical protein |
Loa Loa (eye worm) | LOAG_08439 | hypothetical protein |
Mycobacterium leprae | ML0728c | Probable thiosulfate sulfurtransferase SseA (RHODANESE) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRANSFERASE) |
Mycobacterium leprae | ML2198 | PROBABLE THIOSULFATE SULFURTRANSFERASE CYSA2 (RHODANESE-LIKE PROTEIN) (THIOSULFATE CYANIDE TRANSSULFURASE) (THIOSULFATE THIOTRAN |
Mus musculus | ENSMUSG00000044986 | thiosulfate sulfurtransferase, mitochondrial |
Mus musculus | ENSMUSG00000071711 | mercaptopyruvate sulfurtransferase |
Mycobacterium tuberculosis | Rv3283 | Probable thiosulfate sulfurtransferase SseA (rhodanese) (thiosulfate cyanide transsulfurase) (thiosulfate thiotransferase) |
Mycobacterium tuberculosis | Rv0815c | Probable thiosulfate sulfurtransferase CysA2 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran |
Mycobacterium tuberculosis | Rv3117 | Probable thiosulfate sulfurtransferase CysA3 (rhodanese-like protein) (thiosulfate cyanide transsulfurase) (thiosulfate thiotran |
Mycobacterium tuberculosis | Rv2291 | Probable thiosulfate sulfurtransferase SseB |
Mycobacterium ulcerans | MUL_2635 | thiosulfate sulfurtransferase SseA |
Mycobacterium ulcerans | MUL_0432 | thiosulfate sulfurtransferase, CysA2 |
Neospora caninum | NCLIV_070240 | Thiosulfate sulfurtransferase, related |
Oryza sativa | 4352752 | Os12g0608600 |
Oryza sativa | 4328418 | Os02g0167100 |
Plasmodium berghei | PBANKA_0605000 | rhodanese like protein, putative |
Plasmodium falciparum | PF3D7_1206400 | rhodanese like protein, putative |
Plasmodium knowlesi | PKNH_1306400 | rhodanese like protein, putative |
Plasmodium vivax | PVX_084355 | rhodanese like protein, putative |
Plasmodium yoelii | PY01845 | hypothetical protein |
Saccharomyces cerevisiae | YOR251C | Tum1p |
Trypanosoma brucei gambiense | Tbg972.7.6900 | mercaptopyruvate sulfurtransferase, putative |
Trypanosoma brucei | Tb927.7.5920 | mercaptopyruvate sulfurtransferase, putative |
Trypanosoma congolense | TcIL3000_7_4940 | mercaptopyruvate sulfurtransferase, putative |
Trypanosoma cruzi | TcCLB.508173.40 | mercaptopyruvate sulfurtransferase, putative |
Toxoplasma gondii | TGME49_305910 | hypothetical protein |
Trichomonas vaginalis | TVAG_129830 | thiosulfate sulfertansferase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu3170 | Mycobacterium tuberculosis | non-essential | nmpdr |
Tb927.7.5920 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.5920 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.5920 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.5920 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b1757 | Escherichia coli | non-essential | goodall |
b2521 | Escherichia coli | non-essential | goodall |
TGME49_305910 | Toxoplasma gondii | Essentiality uncertain | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
2 literature references were collected for this gene.