Detailed view for PF3D7_1106100

Basic information

TDR Targets ID: 1551
Plasmodium falciparum, apicoplast ribosomal protein S15 precursor, putative
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 10.559 | Length (AA): 269 | MW (Da): 32403 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 1

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00312   Ribosomal protein S15

Gene Ontology

Mouse over links to read term descriptions.
GO:0020011   apicoplast  
GO:0005840   ribosome  
GO:0005622   intracellular  
GO:0003735   structural constituent of ribosome  
GO:0006412   translation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
137 218 2avy (O) 7 88 38.00 0.000000056 1 0.88 -1.06
127 216 1a32 (A) 2 86 44.00 0 0.69 0.748272 0.34
131 217 2vqe (O) 2 88 39.00 0 0.93 0.89212 -0.97
137 216 4iyl (A) 8 87 41.00 0.00000000005 0.94 0.736098 0.54

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile sporozoite, Sporozoite. PlasmoDB Zanghi G
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile intra-erythrocytic - 32 hs, early schizont, late trophozoite, Oocyst, Ring, Female Gametocyte. Otto TD PlasmoDB Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, gametocyte, early trophozoite, late schizont, Male Gametocyte. Otto TD PlasmoDB Lasonder E
Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile intra-erythrocytic - 0 hs. Otto TD
Show/Hide expression data references
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • PlasmoDB Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB

Orthologs

Ortholog group members (OG5_127663)

Species Accession Gene Product
Arabidopsis thaliana AT1G80620   S15/NS1, RNA-binding protein
Arabidopsis thaliana AT1G15810   S15/NS1, RNA-binding protein
Babesia bovis BBOV_III007430   30S ribosomal protein S15
Candida albicans CaO19.2520   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPS28 (YDR337W) small subunit protein (E. coli S15)
Candida albicans CaO19.10056   likely mitochondrial ribosomal protein similar to S. cerevisiae MRPS28 (YDR337W) small subunit protein (E. coli S15)
Chlamydia trachomatis CT_843   30S ribosomal protein S15
Dictyostelium discoideum DDB_G0289469   hypothetical protein
Drosophila melanogaster Dmel_CG4207   CG4207 gene product from transcript CG4207-RA
Escherichia coli b3165   30S ribosomal subunit protein S15
Echinococcus granulosus EgrG_000191300   expressed conserved protein
Echinococcus multilocularis EmuJ_000191300   expressed conserved protein
Homo sapiens ENSG00000116898   mitochondrial ribosomal protein S15
Mycobacterium leprae ML0853   PROBABLE 30S RIBOSOMAL PROTEIN S15 RPSO
Mus musculus ENSMUSG00000028861   mitochondrial ribosomal protein S15
Mycobacterium tuberculosis Rv2785c   30S ribosomal protein S15 RpsO
Mycobacterium ulcerans MUL_2147   30S ribosomal protein S15
Neospora caninum NCLIV_058640   ribosomal protein S15, putative
Oryza sativa 4331046   Os02g0803200
Plasmodium berghei PBANKA_0940800   apicoplast ribosomal protein S15 precursor, putative
Plasmodium falciparum PF3D7_1106100   apicoplast ribosomal protein S15 precursor, putative
Plasmodium knowlesi PKNH_0903700   ribosomal protein S15, putative
Plasmodium vivax PVX_090980   30S ribosomal protein S15, putative
Plasmodium yoelii PY03370   ribosomal protein S15, putative
Saccharomyces cerevisiae YDR337W   mitochondrial 37S ribosomal protein MRPS28
Schistosoma japonicum Sjp_0061660   IPR009068,S15/NS1, RNA-binding,domain-containing
Schistosoma mansoni Smp_074210   hypothetical protein
Schmidtea mediterranea mk4.034460.00  
Toxoplasma gondii TGME49_316110   ribosomal protein RPS15
Treponema pallidum TP0887   30S ribosomal protein S15
Theileria parva TP04_0924   hypothetical protein
Wolbachia endosymbiont of Brugia malayi Wbm0020   30S ribosomal protein S15

Essentiality

PF3D7_1106100 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b3165 Escherichia coli essential goodall
PBANKA_0940800 Plasmodium berghei Essential plasmo
TGME49_316110 Toxoplasma gondii Probably essential sidik
Show/Hide essentiality data references
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier PF3D7_1106100 (Plasmodium falciparum), apicoplast ribosomal protein S15 precursor, putative
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