Detailed view for Tb927.11.10020

Basic information

TDR Targets ID: 16077
Trypanosoma brucei, short-chain dehydrogenase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 9.7594 | Length (AA): 313 | MW (Da): 33959 | Paralog Number: 0

Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 2

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00106   short chain dehydrogenase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0016491   oxidoreductase activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0008152   metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_130166)

Species Accession Gene Product
Brugia malayi Bm1_09265   Dehydrogenases, short chain protein 30
Caenorhabditis elegans CELE_T25G12.7   Protein DHS-30
Caenorhabditis elegans CELE_T25G12.13   Protein T25G12.13
Caenorhabditis elegans CELE_T25G12.2   Protein T25G12.2
Drosophila melanogaster Dmel_CG7601   CG7601 gene product from transcript CG7601-RA
Giardia lamblia GL50803_8382   Short-chain dehydrogenase, putative
Homo sapiens ENSG00000109016   dehydrogenase/reductase (SDR family) member 7B
Leishmania braziliensis LbrM.35.3640   short chain dehydrogenase-like protein
Leishmania donovani LdBPK_363570.1   short chain dehydrogenase-like protein
Leishmania infantum LinJ.36.3570   short chain dehydrogenase-like protein
Leishmania major LmjF.36.3410   short chain dehydrogenase-like protein
Leishmania mexicana LmxM.36.3410   short chain dehydrogenase-like protein
Loa Loa (eye worm) LOAG_13677   dehydrogenase
Loa Loa (eye worm) LOAG_12558   hypothetical protein
Mus musculus ENSMUSG00000042569   dehydrogenase/reductase (SDR family) member 7B
Mycobacterium tuberculosis Rv3391   Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1
Mycobacterium tuberculosis Rv0945   Probable short-chain type dehydrogenase/reductase
Mycobacterium tuberculosis Rv1050   Probable oxidoreductase
Mycobacterium ulcerans MUL_4417   short chain dehydrogenase
Mycobacterium ulcerans MUL_4346   multi-functional enzyme with acyl-CoA-reductase activity AcrA1
Mycobacterium ulcerans MUL_0918   short chain dehydrogenase
Mycobacterium ulcerans MUL_3139   short-chain dehydrogenase
Oryza sativa 4329454   Os02g0511400
Oryza sativa 4350557   Os11g0499600
Schmidtea mediterranea mk4.005667.01  
Schmidtea mediterranea mk4.010259.00  
Trypanosoma brucei gambiense Tbg972.11.11250   short-chain dehydrogenase, putative
Trypanosoma brucei Tb927.11.10020   short-chain dehydrogenase, putative
Trypanosoma congolense TcIL3000_0_45550   short-chain dehydrogenase, putative
Trypanosoma congolense TcIL3000.11.10540   short-chain dehydrogenase, putative
Trypanosoma cruzi TcCLB.509749.39   short-chain dehydrogenase, putative
Trypanosoma cruzi TcCLB.510719.20   short-chain dehydrogenase, putative

Essentiality

Tb927.11.10020 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
mtu3451 Mycobacterium tuberculosis non-essential nmpdr
Tb11.01.1780 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.1780 this record Trypanosoma brucei significant loss of fitness in bloodstream forms (6 days) alsford
Tb11.01.1780 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.1780 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.4

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Macaca mulatta Hydroxysteroid 11-beta dehydrogenase 1 140 aa 26.0% 154 aa Compounds References
Cochliobolus lunatus 17-beta-hydroxysteroid-dehydrogenase 270 aa 23.0% 248 aa Compounds References
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 301 aa 23.5% 251 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.008 0.5 0.5
0.0073 0.4546 1
0.0408 0.5144 1
0.0082 1 0.5
0.0132 0.3658 1
0.0009 0.5 0.5
0.0196 0.8679 1
0.0009 0.5 0.5
0.007 1 1
0.0106 0.5 0.5
0.0053 1 1
0.0004 0.5 0.5
0.0089 0.5 0.5
0.007 1 1
0.0058 0.3931 1
0.011 0.3568 1
0.0056 0.875 1
0.0009 0.5 0.5
0.0012 0.5 0.5
0.0016 0.5 0.5
0.0162 1 1
0.0058 1 1
0.0064 0.3508 0.5
0.0019 0.4322 1
0.0057 0.284 0.6352
0.0004 0.5 0.5
0.0032 1 1
0.0106 1 0.5
0.0068 1 1
0.0097 0.4304 1
0.0123 0.5 0.5
0.0027 0.5 0.5
0.0004 0.5 0.5
0.0408 0.5144 1
0.0021 0.5 0.5
0.0089 0.5 0.5
0.0013 0.5 0.5
0.0012 0.5 0.5
0.0021 0.3321 0.5
0.0066 0.3586 0.5
0.0196 0.8679 1
0.007 0.2916 1
0.0068 0.2585 0.5
0.0068 1 1
0.0009 0.5 0.5
0.0027 0.5 0.5
0.0067 0.3468 1
0.0009 0.5 0.5
0.0113 1 1
0.0026 0.5 0.5
0.0045 1 1
0.0196 0.8679 1
0.0408 0.5144 1
0.0106 1 1
0.0087 0.5 0.5
0.0088 1 1
0.0004 0.5 0.5
0.0171 0.4063 0.5
0.0106 0.2872 1
0.0114 1 0.5
0.0071 0.3141 0.5
0.0039 1 1
0.0009 0.5 0.5
0.0009 0.5 0.5
0.0035 1 1
0.0013 1 0.5
0.0009 1 0.5
0.016 0.577 1
0.0073 0.2873 1
0.0073 0.3141 1
0.0118 1 1
0.0021 0.3321 0.5
0.0119 0.2746 1
0.0102 0.7451 0.5
0.0046 0.3082 0
0.0005 0.5 0.5
0.0088 0.6544 1
0.007 0.2916 1
0.0131 0.5 0.5
0.0084 0.4283 0.4283
0.0005 0.5 0.5
0.0165 1 1
0.0076 1 1
0.0114 1 0.5
0.0004 0.5 0.5
0.0171 0.4063 0.5
0.0085 1 1
0.0009 0.7374 0.5
0.0108 0.5 0.5
0.0009 0.5 0.5
0.004 0.5 0.5
0.016 0.577 1
0.0093 0.5 0.5
0.0218 0.5 0.5
0.0073 0.3811 1
0.0073 0.3811 1
0.0004 0.5 0.5
0.0004 0.5 0.5
0.007 0.2916 1
0.0097 1 1
0.0402 1 1
0.0222 0.5 0.5
0.0053 1 1
0.0056 1 1
0.0157 0.5 0.5
0.007 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

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Gene identifier Tb927.11.10020 (Trypanosoma brucei), short-chain dehydrogenase, putative
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