pI: 7.5126 |
Length (AA): 195 |
MW (Da): 21731 |
Paralog Number:
0
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
11 | 193 | 1z81 (A) | 25 | 210 | 44.00 | 0 | 1 | 1.48 | -1.1 |
24 | 193 | 2haq (A) | 22 | 187 | 61.00 | 0 | 1 | 1.69 | -1.51 |
29 | 193 | 2gw2 (A) | 8 | 177 | 52.00 | 0 | 1 | 1.61 | -1.8 |
16 | 193 | 1ihg (A) | 3 | 184 | 51.00 | 0 | 1 | 1.61462 | -1.23 |
24 | 193 | 2haq (A) | 22 | 187 | 62.00 | 0 | 1 | 1.68999 | -1.36 |
29 | 193 | 1qng (A) | 5 | 171 | 57.00 | 0 | 1 | 1.65395 | -1.59 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Resolution | Method | # Atoms | # Residues | Dep. Date | Pub. Date | Mod. Date |
---|---|---|---|---|---|---|
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, sporozoite, early ring, early schizont, late ring, late schizont, late trophozoite, Oocyst, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | intra-erythrocytic - 8 hs, merozoite, early trophozoite. | Otto TD PlasmoDB |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | gametocyte, Female Gametocyte, Male Gametocyte. | PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Sporozoite. | Zanghi G |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Ortholog group members (OG5_127452)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G29960 | peptidyl-prolyl cis-trans isomerase CYP19-4 |
Arabidopsis thaliana | AT5G58710 | cyclophilin ROC7 |
Arabidopsis thaliana | AT5G13120 | peptidyl-prolyl cis-trans isomerase CYP20-2 |
Arabidopsis thaliana | AT3G62030 | peptidyl-prolyl cis-trans isomerase CYP20-3 |
Babesia bovis | BBOV_I000280 | peptidylprolyl isomerase, putative |
Brugia malayi | Bm1_24035 | cyclophilin-type peptidyl-prolyl cis-trans isomerase-15, Bmcyp-5 |
Brugia malayi | Bm1_49715 | cyclophilin-type peptidyl-prolyl cis-trans isomerase-6, Bmcyp-6 |
Brugia malayi | Bm1_19855 | cyclophilin-type peptidyl-prolyl cis-trans isomerase-18, Bmcyp-18 |
Candida albicans | CaO19.7421 | likely cyclophilin type peptidyl-prolyl cis-trans isomerase similar to E.nidulans cypB and to S. cerevisiae CPR5 (YDR304C) |
Caenorhabditis elegans | CELE_F31C3.1 | Protein CYN-5 |
Caenorhabditis elegans | CELE_F42G9.2 | Protein CYN-6 |
Dictyostelium discoideum | DDB_G0269120 | cyclophilin B |
Drosophila melanogaster | Dmel_CG2852 | CG2852 gene product from transcript CG2852-RD |
Echinococcus granulosus | EgrG_001015600 | peptidyl prolyl cis trans isomerase B |
Entamoeba histolytica | EHI_128100 | peptidyl-prolyl cis-trans isomerase, putative |
Echinococcus multilocularis | EmuJ_001015600 | peptidyl prolyl cis trans isomerase B |
Giardia lamblia | GL50803_17163 | Peptidyl-prolyl cis-trans isomerase B precursor |
Homo sapiens | ENSG00000166794 | peptidylprolyl isomerase B (cyclophilin B) |
Leishmania braziliensis | LbrM.06.0100 | cyclophilin 2 |
Leishmania donovani | LdBPK_060120.1 | cyclophilin |
Leishmania infantum | LinJ.06.0120 | cyclophilin 2 |
Leishmania major | LmjF.06.0120 | cyclophilin 2 |
Leishmania mexicana | LmxM.06.0120 | cyclophilin |
Loa Loa (eye worm) | LOAG_00140 | CYN-5 protein |
Loa Loa (eye worm) | LOAG_13609 | cyclophilin-type peptidyl-prolyl cis-trans isomerase-18 |
Loa Loa (eye worm) | LOAG_00699 | cyclophilin-type peptidyl-prolyl cis-trans isomerase-15 |
Mus musculus | ENSMUSG00000032383 | peptidylprolyl isomerase B |
Oryza sativa | 4337539 | Os05g0103200 |
Oryza sativa | 4327912 | Os01g0284700 |
Oryza sativa | 4342022 | Os06g0708500 |
Onchocerca volvulus | OVOC1727 |
|
Plasmodium berghei | PBANKA_0932200 | peptidyl-prolyl cis-trans isomerase, putative |
Plasmodium falciparum | PF3D7_1115600 | peptidyl-prolyl cis-trans isomerase |
Plasmodium knowlesi | PKNH_0913200 | peptidylprolyl isomerase precursor, putative |
Plasmodium vivax | PVX_091425 | peptidyl-prolyl cis-trans isomerase 11, putative |
Plasmodium yoelii | PY00781 | peptidyl-prolyl cis-trans isomerase, cyclophilin-type |
Saccharomyces cerevisiae | YHR057C | peptidylprolyl isomerase CPR2 |
Saccharomyces cerevisiae | YDR304C | peptidylprolyl isomerase family protein CPR5 |
Schistosoma japonicum | Sjp_0206950 | ko:K03768 peptidyl-prolyl cis-trans isomerase B (cyclophilin B), putative |
Schistosoma mansoni | Smp_040790 | cyclophilin B |
Schmidtea mediterranea | mk4.026224.00 | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme |
Schmidtea mediterranea | mk4.007569.01 | Peptidyl-prolyl cis-trans isomerase |
Schmidtea mediterranea | mk4.002772.00 | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme |
Schmidtea mediterranea | mk4.000140.03 | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme |
Schmidtea mediterranea | mk4.002453.00 | Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme |
Trypanosoma brucei gambiense | Tbg972.7.5450 | cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma brucei | Tb11.v5.0160 | cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma brucei | Tb927.7.4770 | cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma congolense | TcIL3000_7_3940 | cyclophilin-type peptidyl-prolyl cis-trans isomerase, putative |
Trypanosoma cruzi | TcCLB.507521.70 | cyclophilin, putative |
Trypanosoma cruzi | TcCLB.508577.140 | cyclophilin, putative |
Trichomonas vaginalis | TVAG_038810 | peptidyl-prolyl cis-trans isomerase D, ppid, putative |
Trichomonas vaginalis | TVAG_062520 | cyclophilin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.4770 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.4770 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.4770 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.4770 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.6
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | peptidylprolyl isomerase B (cyclophilin B) | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Cyclophilin A | 164 aa | 53.7% | 162 aa | Compounds | References |
Plasmodium falciparum | peptidyl-prolyl cis-trans isomerase | 171 aa | 56.6% | 166 aa | Compounds | References |
13 literature references were collected for this gene.