pI: 5.7547 |
Length (AA): 225 |
MW (Da): 23950 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
19 | 207 | 3dh1 (A) | 17 | 173 | 43.00 | 0 | 1 | 1.1109 | 0.14 |
27 | 161 | 2a8n (A) | 7 | 108 | 45.00 | 0.0000000000063 | 0.99 | 0.7389 | 0.65 |
27 | 220 | 1z3a (A) | 22 | 167 | 36.00 | 0 | 1 | 0.915822 | 0.6 |
72 | 151 | 2g84 (A) | 59 | 127 | 33.00 | 0.78 | 0.25 | 0.434456 | 1.21 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126941)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G48175 | tRNA adenosine deaminase 1 |
Arabidopsis thaliana | AT1G68720 | tRNA(adenine(34)) deaminase |
Babesia bovis | BBOV_III000450 | cytosine deaminase, putative |
Brugia malayi | Bm1_29930 | tRNA-specific adenosine deaminase 2 |
Candida albicans | CaO19.1458 | similar to S. cerevisiae TAD2 (YJL035C) subunit of adenosine deaminase that converts the tRNA wobble position to insosine |
Candida albicans | CaO19.9033 | similar to S. cerevisiae TAD2 (YJL035C) subunit of adenosine deaminase that converts the tRNA wobble position to insosine |
Caenorhabditis elegans | CELE_JC8.4 | Protein JC8.4 |
Cryptosporidium hominis | Chro.20177 | cytidine and deoxycytidylate deaminase family |
Cryptosporidium parvum | cgd2_1630 | cytidine and deoxycytidylate deaminase family, putative |
Chlamydia trachomatis | CT_844 | tRNA-specific adenosine deaminase |
Dictyostelium discoideum | DDB_G0288099 | adenosine deaminase, tRNA-specific |
Drosophila melanogaster | Dmel_CG5292 | CG5292 gene product from transcript CG5292-RB |
Escherichia coli | b2559 | tRNA-specific adenosine deaminase |
Echinococcus granulosus | EgrG_000788300 | tRNA specific adenosine deaminase 2 |
Entamoeba histolytica | EHI_169890 | cytidine/deoxycytidylate deaminase family protein |
Echinococcus multilocularis | EmuJ_000788300 | tRNA specific adenosine deaminase 2 |
Giardia lamblia | GL50803_2486 | Cytosine deaminase, putative |
Homo sapiens | ENSG00000189007 | adenosine deaminase, tRNA-specific 2 |
Leishmania braziliensis | LbrM.10.0850 | deaminase, putative |
Leishmania donovani | LdBPK_100780.1 | deaminase, putative |
Leishmania infantum | LinJ.10.0780 | deaminase, putative |
Leishmania major | LmjF.10.0730 | deaminase, putative |
Leishmania mexicana | LmxM.10.0730 | deaminase, putative |
Loa Loa (eye worm) | LOAG_06088 | tRNA-specific adenosine deaminase 2 |
Mycobacterium leprae | ML2474 | possible cytidine/deoxycytidylate deaminase |
Mus musculus | ENSMUSG00000019808 | adenosine deaminase, tRNA-specific 2 |
Mycobacterium tuberculosis | Rv3752c | Possible cytidine/deoxycytidylate deaminase |
Mycobacterium ulcerans | MUL_4370 | cytidine/deoxycytidylate deaminase |
Neospora caninum | NCLIV_027210 | Cytidine and deoxycytidylate deaminase family protein, related |
Oryza sativa | 4332682 | Os03g0321900 |
Oryza sativa | 4341078 | Os06g0489500 |
Plasmodium berghei | PBANKA_1362200 | cytidine and deoxycytidylate deaminase, putative |
Plasmodium falciparum | PF3D7_1349400 | cytidine and deoxycytidylate deaminase, putative |
Plasmodium knowlesi | PKNH_1251500 | cytidine and deoxycytidylate deaminase, putative |
Plasmodium vivax | PVX_083365 | cytidine and deoxycytidylate deaminase, putative |
Plasmodium yoelii | PY04017 | hypothetical protein |
Saccharomyces cerevisiae | YPR062W | cytosine deaminase |
Saccharomyces cerevisiae | YJL035C | Tad2p |
Schistosoma japonicum | Sjp_0087990 | ko:K01500 adenosine deaminase, tRNA-specific 2, TAD2 homolog [EC:3.5.4.-], putative |
Schistosoma mansoni | Smp_053790 | cytidine/deoxycytidylate deaminase-related |
Schistosoma mansoni | Smp_053780 | cytidine/deoxycytidylate deaminase-related |
Trypanosoma brucei gambiense | Tbg972.8.3890 | deaminase, putative |
Trypanosoma brucei | Tb927.8.4180 | tRNA-specific adenosine deaminase |
Trypanosoma congolense | TcIL3000_8_3880 | deaminase, putative |
Trypanosoma cruzi | TcCLB.503897.80 | deaminase, putative |
Trypanosoma cruzi | TcCLB.509561.120 | deaminase, putative |
Toxoplasma gondii | TGME49_259570 | CMP/dCMP deaminase, zinc-binding, putative |
Theileria parva | TP03_0793 | cytidine deaminase, putative |
Trichomonas vaginalis | TVAG_087960 | riboflavin-specific deaminase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0168 | cytosine/adenosine deaminase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.4180 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.4180 this record | Trypanosoma brucei | significant gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.4180 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.4180 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
b2559 | Escherichia coli | essential | goodall |
CELE_JC8.4 | Caenorhabditis elegans | embryonic lethal | wormbase |
YJL035C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_259570 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | increased (PATO:0000470) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
9 literature references were collected for this gene.