pI: 3.857 |
Length (AA): 149 |
MW (Da): 16839 |
Paralog Number:
3
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
NA% percentile | Procyclic. | Siegel TN |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126800)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G21274 | calmodulin 6 |
Arabidopsis thaliana | AT2G41110 | calmodulin 2 |
Arabidopsis thaliana | AT3G56800 | calmodulin 3 |
Arabidopsis thaliana | AT1G66410 | calmodulin 4 |
Arabidopsis thaliana | AT3G43810 | calmodulin 7 |
Arabidopsis thaliana | AT2G27030 | calmodulin 5 |
Babesia bovis | BBOV_I004080 | calmodulin |
Brugia malayi | Bm1_50415 | calmodulin |
Candida albicans | CaO19.4413 | likely calmodulin 3' exon |
Candida albicans | CaO19.11891 | likely calmodulin 3' exon |
Caenorhabditis elegans | CELE_T21H3.3 | Protein CMD-1 |
Cryptosporidium hominis | Chro.20092 | calmodulin |
Cryptosporidium parvum | cgd2_810 | calmodulin |
Dictyostelium discoideum | DDB_G0279407 | hypothetical protein |
Drosophila melanogaster | Dmel_CG8472 | Calmodulin |
Echinococcus granulosus | EgrG_000491400 | CalModulin family member cmd 1 |
Echinococcus granulosus | EgrG_000532700 | calmodulin |
Echinococcus granulosus | EgrG_000889000 | calmodulin |
Echinococcus granulosus | EgrG_000605300 | calmodulin |
Echinococcus granulosus | EgrG_000344500 | calmodulin |
Entamoeba histolytica | EHI_100270 | calmodulin, putative |
Echinococcus multilocularis | EmuJ_000747100 | calmodulin |
Echinococcus multilocularis | EmuJ_000344500 | calmodulin |
Echinococcus multilocularis | EmuJ_000490200 | calmodulin |
Echinococcus multilocularis | EmuJ_000605300 | calmodulin |
Echinococcus multilocularis | EmuJ_000532700 | calmodulin |
Echinococcus multilocularis | EmuJ_000889000 | calmodulin |
Echinococcus multilocularis | EmuJ_000491400 | CalModulin family member (cmd 1) |
Giardia lamblia | GL50803_5333 | Calmodulin |
Homo sapiens | ENSG00000160014 | calmodulin 3 (phosphorylase kinase, delta) |
Homo sapiens | ENSG00000143933 | calmodulin 2 (phosphorylase kinase, delta) |
Homo sapiens | ENSG00000198668 | calmodulin 1 (phosphorylase kinase, delta) |
Homo sapiens | 810 | calmodulin-like 3 |
Leishmania braziliensis | LbrM.09.0970 | calmodulin, putative |
Leishmania braziliensis | LbrM.09.0960 | calmodulin, putative |
Leishmania braziliensis | LbrM.09.0980 | calmodulin, putative |
Leishmania donovani | LdBPK_090980.1 | calmodulin, putative |
Leishmania donovani | LdBPK_090970.1 | calmodulin, putative |
Leishmania infantum | LinJ.09.0970 | calmodulin, putative |
Leishmania infantum | LinJ.09.0980 | calmodulin, putative |
Leishmania major | LmjF.09.0920 | calmodulin, putative |
Leishmania major | LmjF.09.0910 | calmodulin, putative |
Leishmania major | LmjF.09.0930 | calmodulin, putative |
Leishmania mexicana | LmxM.09.0910 | calmodulin, putative |
Leishmania mexicana | LmxM.09.0930 | calmodulin, putative |
Leishmania mexicana | LmxM.09.0920 | calmodulin, putative |
Loa Loa (eye worm) | LOAG_01388 | hypothetical protein |
Mus musculus | ENSMUSG00000063130 | calmodulin-like 3 |
Mus musculus | ENSMUSG00000019370 | calmodulin 3 |
Mus musculus | ENSMUSG00000036438 | calmodulin 2 |
Mus musculus | ENSMUSG00000001175 | calmodulin 1 |
Neospora caninum | NCLIV_065440 | hypothetical protein |
Oryza sativa | 4332664 | Os03g0319300 |
Oryza sativa | 4324384 | Os01g0267900 |
Oryza sativa | 4344344 | Os07g0687200 |
Oryza sativa | 4339172 | Os05g0491100 |
Oryza sativa | 4326903 | Os01g0279300 |
Oryza sativa | 4325693 | Os01g0135700 |
Oryza sativa | 9270836 | Os03g0715600 |
Onchocerca volvulus | OVOC7165 |
|
Onchocerca volvulus | OVOC7077 | Calmodulin homolog |
Plasmodium berghei | PBANKA_1010600 | calmodulin, putative |
Plasmodium falciparum | PF3D7_1434200 | calmodulin |
Plasmodium knowlesi | PKNH_0420800 | calmodulin, putative |
Plasmodium vivax | PVX_084825 | calmodulin, putative |
Plasmodium yoelii | PY06908 | calmodulin |
Saccharomyces cerevisiae | YBR109C | calmodulin |
Schistosoma japonicum | Sjp_0211700 | ko:K02183 calmodulin, putative |
Schistosoma japonicum | Sjp_0306580 | Calmodulin, putative |
Schistosoma mansoni | Smp_026560.2 | calmodulin |
Schmidtea mediterranea | mk4.000167.16 | Calmodulin |
Schmidtea mediterranea | mk4.001174.04 | Calmodulin |
Schmidtea mediterranea | mk4.004858.01 | Calmodulin |
Schmidtea mediterranea | mk4.020243.00 | Calmodulin-like protein 3 |
Schmidtea mediterranea | mk4.000046.23 | |
Schmidtea mediterranea | mk4.014755.00 | |
Schmidtea mediterranea | mk4.024912.01 | |
Schmidtea mediterranea | mk4.008639.00 | |
Schmidtea mediterranea | mk4.010122.01 | |
Schmidtea mediterranea | mk4.003231.01 | |
Schmidtea mediterranea | mk4.004517.00 | Calmodulin-like protein 4 |
Schmidtea mediterranea | mk4.002397.03 | |
Trypanosoma brucei gambiense | Tbg972.11.14490 | calmodulin, putative |
Trypanosoma brucei gambiense | Tbg972.11.14500 | calmodulin, putative |
Trypanosoma brucei gambiense | Tbg972.11.14520 | calmodulin, putative |
Trypanosoma brucei gambiense | Tbg972.11.14480 | |
Trypanosoma brucei gambiense | Tbg972.11.14510 | calmodulin, putative |
Trypanosoma brucei | Tb927.11.13050 | calmodulin |
Trypanosoma brucei | Tb927.11.13030 | calmodulin |
Trypanosoma brucei | Tb927.11.13040 | calmodulin |
Trypanosoma brucei | Tb927.11.13020 | calmodulin |
Trypanosoma cruzi | TcCLB.506391.10 | calmodulin |
Trypanosoma cruzi | TcCLB.506391.20 | calmodulin, putative |
Trypanosoma cruzi | TcCLB.506389.79 | calmodulin, putative |
Trypanosoma cruzi | TcCLB.507483.30 | calmodulin, putative |
Trypanosoma cruzi | TcCLB.507483.39 | calmodulin |
Toxoplasma gondii | TGME49_249240 | calmodulin, putative |
Theileria parva | TP02_0717 | calmodulin, putative |
Trichomonas vaginalis | TVAG_038070 | calmodulin, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.01.4621 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb11.01.4621 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.01.4621 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.01.4621 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T21H3.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T21H3.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_T21H3.3 | Caenorhabditis elegans | sterile | wormbase |
YBR109C | Saccharomyces cerevisiae | inviable | yeastgenome |
TGME49_249240 | Toxoplasma gondii | Probably essential | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | calmodulin 2 (phosphorylase kinase, delta) | Compounds | References |
Bos taurus | Calmodulin | Compounds | References |
1 literature reference was collected for this gene.