Detailed view for Tb10.v4.0134

Basic information

TDR Targets ID: 17092
Trypanosoma brucei, variant surface glycoprotein (VSG), putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.5327 | Length (AA): 511 | MW (Da): 54222 | Paralog Number: 14

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00913   Trypanosome variant surface glycoprotein (A-type)

Gene Ontology

Mouse over links to read term descriptions.
GO:0020012   evasion or tolerance of host immune response  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
NA% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_132063)

Species Accession Gene Product
Saccharomyces cerevisiae YKL163W   Pir3p
Trypanosoma brucei Tb927.9.17410   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb927.9.890   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb09.v4.0050   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0461   Variant Surface Glycoprotein, putative
Trypanosoma brucei Tb11.v5.0121   variant surface protein (VSG), putative
Trypanosoma brucei Tb10.v4.0078   hypothetical protein
Trypanosoma brucei Tb08.27P2.410   variant surface glycoprotein, degenerate, interrupted
Trypanosoma brucei Tb927.11.17560   variant surface glycoprotein (VSG), frameshifted and point mutation
Trypanosoma brucei Tb11.v5.1008   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.11.20240   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb11.v5.1019   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb10.v4.0134   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb927.4.5700   variant surface glycoprotein (VSG, atypical), putative
Trypanosoma brucei Tb10.v4.0117   variant surface glycoprotein (VSG), putative
Trypanosoma brucei Tb11.v5.0143   variant surface protein (VSG), putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease 99 aa 27.5% 80 aa Compounds References
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb10.v4.0134 (Trypanosoma brucei), variant surface glycoprotein (VSG), putative
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