pI: 9.6354 |
Length (AA): 219 |
MW (Da): 24295 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126974)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G03457 | RNA recognition motif-containing protein |
Arabidopsis thaliana | AT4G03110 | RNA-binding protein-defense related 1 |
Babesia bovis | BBOV_I003530 | RNA recognition motif. (a.k.a. RRM, RBD, or RNP) domain containing protein |
Brugia malayi | Bm1_27610 | RNA binding protein |
Brugia malayi | Bm1_47110 | RNA recognition motif. |
Caenorhabditis elegans | CELE_C17D12.2 | Protein UNC-75 |
Caenorhabditis elegans | CELE_T01D1.2 | Protein ETR-1, isoform C |
Cryptosporidium hominis | Chro.40387 | RNA binding protein |
Cryptosporidium parvum | cgd4_3410 | RNA binding protein, putative |
Dictyostelium discoideum | DDB_G0291486 | RNA recognition motif-containing protein RRM |
Dictyostelium discoideum | DDB_G0270634 | RNA recognition motif-containing protein RRM |
Drosophila melanogaster | Dmel_CG43744 | bruno-3 |
Drosophila melanogaster | Dmel_CG31762 | arrest |
Echinococcus granulosus | EgrG_000940400 | CUGBP Elav family |
Echinococcus granulosus | EgrG_000362600 | bruno-like rna binding protein |
Echinococcus granulosus | EgrG_000942800 | bruno-like rna binding protein |
Echinococcus granulosus | EgrG_000942900 | bruno-like rna binding protein |
Echinococcus granulosus | EgrG_000362500 | bruno-like rna binding protein |
Echinococcus multilocularis | EmuJ_000382900 | alternative splicing factor ASF 1 |
Echinococcus multilocularis | EmuJ_000940400 | bruno-like rna binding protein |
Echinococcus multilocularis | EmuJ_000362500 | CUGBP Elav family |
Echinococcus multilocularis | EmuJ_000942800 | bruno-like rna binding protein |
Echinococcus multilocularis | EmuJ_000362600 | bruno 4, RNA binding protein |
Echinococcus multilocularis | EmuJ_000943000 | bruno-like rna binding protein |
Homo sapiens | ENSG00000140488 | CUGBP, Elav-like family member 6 |
Homo sapiens | ENSG00000101489 | CUGBP, Elav-like family member 4 |
Homo sapiens | ENSG00000149187 | CUGBP, Elav-like family member 1 |
Homo sapiens | ENSG00000161082 | CUGBP, Elav-like family member 5 |
Homo sapiens | ENSG00000048740 | CUGBP, Elav-like family member 2 |
Homo sapiens | 11189 | CUGBP, Elav-like family member 3 |
Leishmania braziliensis | LbrM.25.0450 | RNA-binding protein, putative, UPB1 |
Leishmania braziliensis | LbrM.25.0440 | RNA-binding protein, putative, UPB2 |
Leishmania donovani | LdBPK_250510.1 | RNA-binding protein, putative, UPB2 |
Leishmania infantum | LinJ.25.0510 | RNA-binding protein, putative, UPB2 |
Leishmania infantum | LinJ.25.0500 | RNA-binding protein, putative, UPB1 |
Leishmania major | LmjF.25.0500 | RNA-binding protein, putative, UPB2 |
Leishmania major | LmjF.25.0490 | RNA-binding protein, putative, UPB1 |
Leishmania mexicana | LmxM.25.0490 | RNA-binding protein, putative, UPB1 |
Loa Loa (eye worm) | LOAG_12531 | hypothetical protein |
Loa Loa (eye worm) | LOAG_01549 | hypothetical protein |
Loa Loa (eye worm) | LOAG_05508 | LYST-interacting protein LIP9 |
Mus musculus | ENSMUSG00000002107 | CUGBP, Elav-like family member 2 |
Mus musculus | ENSMUSG00000024268 | CUGBP, Elav-like family member 4 |
Mus musculus | ENSMUSG00000032297 | CUGBP, Elav-like family member 6 |
Mus musculus | ENSMUSG00000028137 | CUGBP, Elav-like family member 3 |
Mus musculus | ENSMUSG00000005506 | CUGBP, Elav-like family member 1 |
Mus musculus | ENSMUSG00000034818 | CUGBP, Elav-like family member 5 |
Neospora caninum | NCLIV_038000 | CUG-BP- and ETR-3-like factor 3, related |
Neospora caninum | NCLIV_004400 | hypothetical protein |
Oryza sativa | 4326538 | Os01g0938200 |
Oryza sativa | 4338600 | Os05g0373400 |
Plasmodium berghei | PBANKA_1135700 | CUGBP Elav-like family member 1, putative |
Plasmodium falciparum | PF3D7_1359400 | CUGBP Elav-like family member 1 |
Plasmodium knowlesi | PKNH_1111900 | CUGBP Elav-like family member 1, putative |
Plasmodium vivax | PVX_114940 | CUGBP Elav-like family member 1, putative |
Plasmodium yoelii | PY04528 | FCA gamma-related |
Plasmodium yoelii | PY02887 | ribonucleoprotein homolog F21B7.26 - Arabidopsis thaliana, putative |
Schistosoma japonicum | Sjp_0024790 | CUG-BP- and ETR-3-like factor 5, putative |
Schistosoma japonicum | Sjp_0134780 | CUG-BP- and ETR-3-like factor 6, putative |
Schistosoma mansoni | Smp_041280 | bruno-like rna binding protein |
Schistosoma mansoni | Smp_131780 | bruno-like rna binding protein |
Schmidtea mediterranea | mk4.003256.01 | |
Schmidtea mediterranea | mk4.022251.00 | |
Schmidtea mediterranea | mk4.020210.00 | |
Schmidtea mediterranea | mk4.002580.00 | Bruno-like |
Schmidtea mediterranea | mk4.006823.00 | |
Schmidtea mediterranea | mk4.009730.00 | |
Schmidtea mediterranea | mk4.006823.01 | ELAV-type RNA binding protein variant E |
Schmidtea mediterranea | mk4.022373.00 | ELAV-type RNA binding protein variant E |
Trypanosoma brucei gambiense | Tbg972.11.450 | RNA-binding protein, putative,UBP1B |
Trypanosoma brucei | Tb927.11.500 | RNA-binding protein, UBP1 |
Trypanosoma congolense | TcIL3000.11.470 | UBP1B |
Trypanosoma cruzi | TcCLB.507093.220 | RNA-binding protein, putative |
Toxoplasma gondii | TGME49_268200 | RNA recognition motif-containing protein |
Toxoplasma gondii | TGME49_321500 | RNA recognition motif-containing protein |
Theileria parva | TP01_0497 | RNA-binding protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb11.03.0620 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.03.0620 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb11.03.0620 this record | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb11.03.0620 this record | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_T01D1.2 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_T01D1.2 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_T01D1.2 | Caenorhabditis elegans | sterile | wormbase |
TGME49_268200 | Toxoplasma gondii | Probably essential | sidik |
TGME49_321500 | Toxoplasma gondii | Probably essential | sidik |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
1 literature reference was collected for this gene.