Detailed view for Tb927.10.13680

Basic information

TDR Targets ID: 17943
Trypanosoma brucei, lipase domain protein, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 7.7023 | Length (AA): 696 | MW (Da): 77507 | Paralog Number: 1

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 5

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01764   Lipase (class 3)

Gene Ontology

Mouse over links to read term descriptions.
GO:0004806   triacylglycerol lipase activity  
GO:0006629   lipid metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Lower 20-40% percentile Procyclic, Bloodstream Form. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_129115)

Species Accession Gene Product
Brugia malayi Bm1_28335   Lipase family protein
Caenorhabditis elegans CELE_F42G9.6   Protein F42G9.6, isoform A
Dictyostelium discoideum DDB_G0289839   hypothetical protein
Dictyostelium discoideum DDB_G0291354   hypothetical protein
Dictyostelium discoideum DDB_G0278621   hypothetical protein
Drosophila melanogaster Dmel_CG33174   inactivation no afterpotential E
Echinococcus granulosus EgrG_000642000   sn1 specific diacylglycerol lipase beta
Echinococcus multilocularis EmuJ_000642000   sn1 specific diacylglycerol lipase beta
Homo sapiens ENSG00000164535   diacylglycerol lipase, beta
Homo sapiens ENSG00000134780   diacylglycerol lipase, alpha
Leishmania braziliensis LbrM.18.0180   hypothetical protein, conserved
Leishmania donovani LdBPK_180160.1   Lipase (class 3), putative
Leishmania infantum LinJ.18.0160   hypothetical protein, conserved
Leishmania major LmjF.18.0160   hypothetical protein, conserved
Leishmania mexicana LmxM.18.0160   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_07964   lipase
Mus musculus ENSMUSG00000035735   diacylglycerol lipase, alpha
Mus musculus ENSMUSG00000039206   diacylglycerol lipase, beta
Onchocerca volvulus OVOC7719  
Schmidtea mediterranea mk4.002913.01   Sn1-specific diacylglycerol lipase beta
Trypanosoma brucei gambiense Tbg972.10.16810   lipase domain protein, putative
Trypanosoma brucei Tb927.10.13680   lipase domain protein, putative
Trypanosoma brucei Tb11.v5.0627   lipase domain protein, putative
Trypanosoma congolense TcIL3000_10_11520   lipase domain protein, putative
Trypanosoma congolense TcIL3000_10_11480   lipase domain protein, putative
Trypanosoma cruzi TcCLB.511277.620   hypothetical protein, conserved
Trypanosoma cruzi TcCLB.507993.180   hypothetical protein, conserved
Trichomonas vaginalis TVAG_004510   lipase containing protein, putative
Trichomonas vaginalis TVAG_431360   lipase containing protein, putative

Essentiality

Tb927.10.13680 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.10.13680 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.10.13680 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.10.13680 this record Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb927.10.13680 this record Trypanosoma brucei significant loss of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) increased (PATO:0000470) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: increased cell proliferation (significant gain of fitness) in procyclic forms . References: 21363968
cell proliferation (GO:0008283) decreased (PATO:0000468) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.1

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Mus musculus diacylglycerol lipase, alpha Compounds References
Homo sapiens diacylglycerol lipase, alpha Compounds References
Homo sapiens diacylglycerol lipase, beta Compounds References
Mus musculus diacylglycerol lipase, beta Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0709 1 0.5
0.0575 0.3013 1
0.1305 1 1
0.131 0.3725 1
0.055 0.3588 0.5
0.0173 0.5983 1
0.0419 1 0.5
0.0891 1 1
0.0748 0.2644 0.3342
0.0143 0.6761 1
0.0405 0.7075 0.5
0.1417 0.5 0.5
0.1222 0.3127 1
0.0173 0.3024 0.5
0.0518 1 0.5
0.0173 0.5501 0.5501
0.0766 1 1
0.1312 1 1
0.0173 1 0.5
0.0173 0.5 0.5
0.0464 0.4562 0.5
0.1042 1 1
0.0346 0.3339 0.5
0.0144 0.6608 1
0.0584 0.6168 1
0.1409 0.5 0.5
0.0155 0.2669 0.7135
0.0911 0.6256 1
0.0905 1 1
0.0417 0.5058 1
0.0428 1 0.5
0.1483 1 1
0.0581 1 1
0.0748 0.2644 0.3342
0.0288 0.2828 1
0.0716 1 1
0.0323 1 0.5
0.1082 1 1
0.0416 0.3192 1
0.0703 0.5103 1
0.091 0.2691 1
0.0758 0.349 1
0.2481 0.4173 1
0.0346 1 1
0.1477 1 1
0.1415 1 1
0.061 1 1
0.0173 1 0.5
0.1231 0.6703 0.5
0.135 1 1
0.0288 0.941 1
0.1217 0.3386 1
0.0142 0.2501 1
0.0154 0.6608 1
0.014 0.5 0.5
0.0568 0.9193 1
0.1792 1 0.5
0.2085 0.4228 1
0.0173 0.9206 1
0.0929 1 1
0.5154 0.2563 1
0.1998 0.3339 1
0.0883 1 1
0.0173 0.6907 1
0.0173 0.4288 1
0.1146 1 1
0.0601 0.2913 1
0.2074 0.3705 1
0.1477 1 1
0.1222 0.3127 1
0.0346 0.3339 0.5
0.0418 0.3067 0.5
0.0173 1 0.5
0.0794 0.7696 1
0.0283 0.4856 0.4856
0.2214 1 1
0.0932 0.4647 1
0.1317 0.3339 0.5
0.0543 0.7319 1
0.0744 0.8401 1
0.0861 0.3961 0.5
0.0146 0.3536 0.3964
0.0173 0.302 0.4678
0.0716 1 1
0.1659 1 1
0.1146 1 1
0.0615 0.2617 0.3906
0.0298 0.4126 1
0.1652 1 1
0.0518 1 0.5
0.1507 0.401 0.6181
0.0173 0.5 0.5
0.1045 0.7538 1
0.0851 0.3456 1
0.1772 1 1
0.0292 0.9509 1
0.0173 0.5 0.5
0.1206 0.8343 1
0.0773 0.3129 1
0.029 0.5464 0.5
0.0437 1 1
0.0748 0.2644 0.3342
0.1053 1 1
0.0748 0.2644 0.3342
0.0748 0.2644 0.3342
0.1083 1 1
0.0475 0.964 1
0.0173 0.2924 1
0.087 0.2892 1
0.1083 1 1
0.2374 0.4138 1
0.0499 1 0.5
0.0748 0.2644 0.3342
0.0278 0.3271 1
0.0173 0.6774 1
0.1344 1 1
0.1161 1 1
0.0098 0.3907 1
0.055 0.3588 0.5
0.0142 1 0.5
0.0165 0.4714 0.5
0.0156 0.9194 1
0.0712 0.3206 1
0.0173 0.6608 1
0.0231 1 1
0.0234 0.3569 1
0.0145 0.6608 1
0.1329 1 0.5
0.0173 0.6608 1
0.1729 1 1
0.1507 0.401 0.6181
0.0147 0.2829 1
0.0767 0.3244 1
0.1202 1 1
0.0739 0.2586 1
0.015 0.3756 1
0.0144 0.6608 1
0.1121 1 0.5
0.0763 1 1
0.0173 0.6511 1
0.014 1 1
0.0293985 0.283487 1
0.0427 0.8472 1
0.1346 0.2637 0.631
0.0142 0.3948 1
0.0173 0.5 0.5
0.0173 0.5 0.5
0.0727 1 1
0.0788 0.3328 1
0.0143 0.4356 0.8941
0.105 0.5866 1
0.0156 0.6874 0.5
0.1066 0.7387 1
0.1503 1 0.5
0.0707 0.4436 1
0.144 0.6064 1
0.0173 0.6608 1
0.0346 0.5 0.5
0.0173 0.5 0.5
0.0748 0.2644 0.3342
0.0883 1 1
0.0173 0.4074 0.4074
0.1345 0.5 0.5
0.2456 0.4073 1
0.029 0.929 1
0.0173 1 0.5
0.072 1 1
0.0759 0.442 0.5
0.0173 0.5473 1
0.029 0.5464 0.5
0.1507 0.401 0.6181
0.105 0.5866 1
0.0165 0.4854 1
0.1044 1 1
0.0729 1 0.5
0.1802 0.3681 1
0.0144 0.592 1
0.0589 0.5694 1
0.0897 0.3447 1
0.0145 0.3717 1
0.0069 1 0.5
0.0146 0.4074 1
0.0148 0.2572 1
0.1002 0.5112 0.5
0.0147 0.6537 1
0.029 0.929 1
0.011 0.5 0.5
0.0145 0.6742 1
0.0144 1 0.5
0.0891 0.5 0.5
0.0576 0.381 0.5
0.0289 0.9416 1
0.014 1 1
0.0894 0.26 1
0.0851 0.5345 1
0.0173 0.5415 1
0.0173 0.6608 1
0.0886 1 1
0.0749 0.3554 0.3554
0.0852 1 0.5
0.0346 0.5 0.5
0.0165 0.6608 1
0.1346 0.2637 0.631
0.0346 0.6198 0.5
0.0785 1 1
0.1615 0.4031 1
0.0892 0.4175 1
0.2481 0.4173 1
0.0437 0.5021 1
0.1081 0.6429 0.5
0.0445 0.6173 1
0.1415 0.5 0.5
0.0615 0.2617 0.3906
0.0767 0.9812 1
0.0437 0.5021 1
0.143 1 1
0.1487 1 1
0.0554 0.6054 1
0.0346 0.5 0.5
0.0173 1 1
0.0611 1 1
0.0418 0.3047 0.5
0.0173 0.302 0.4678
0.0147 0.3948 1
0.0173 0.3367 1
0.0422 0.461 1
0.1253 1 1
0.1295 1 1
0.0143 0.4333 1
0.139 1 1
0.1222 0.3127 1
0.0173 0.5 0.5
0.1507 1 0.5
0.0173 1 0.5
0.1133 0.3368 1
0.0173 1 0.5
0.014 0.3712 0.5895
0.0909 1 0.5
0.0716 1 0.5
0.1187 1 0.5
0.044 1 1
0.0764 0.3309 1
0.1507 0.401 0.6181
0.0154 1 0.5
0.0173 1 1
0.0173 1 0.5
0.043 0.832 1
0.0346 0.5 0.5
0.0764 0.35 1
0.1066 0.6185 1
0.0346 0.3339 0.5
0.168 0.3667 1
0.0605 0.5017 1
0.129 0.5784 1
0.1016 0.4012 1
0.1507 0.401 0.6181
0.0749 0.3554 0.3554
0.1616 0.7397 1
0.1477 1 1
0.0875 0.3724 1
0.0173 1 0.5
0.0141 0.6608 1
0.0231 1 1
0.1222 1 1
0.0148 0.6608 1
0.1641 0.631 1
0.0173 0.9424 0.5
0.1282 0.5514 1
0.0173 0.3053 1
0.142 1 1
0.0769 1 1
0.1231 0.6703 0.5
0.1189 1 1
0.0173 0.7076 1
0.0120321 0.342566 0.310286
0.1439 1 1
0.0908 0.2535 1
0.0288178 0.374316 0.894113
0.0138 0.4764 0.5
0.0748 0.2644 0.3342
0.0566 0.6987 1
0.1066 0.6185 1
0.0612 0.4079 1
0.1222 0.3127 1
0.0173 0.6608 1
0.0173 1 0.5
0.2141 0.3589 1
0.0595 0.4599 1
0.1333 0.5262 1
0.0284 0.9224 1
0.0601 0.2913 1
0.2301 0.3952 1
0.0297 0.2642 1
0.1034 0.6817 1
0.0428 0.2889 1
0.0173 1 1
0.0455 1 1
0.0148 0.276 0.9612
0.0144 0.267 1
0.0173 0.3414 1
0.0299 0.9311 1
0.0284 0.9224 1
0.0173 0.4384 0.5
0.0141 0.5 0.5
0.0748 0.2644 0.3342
0.0922 1 1
0.0155 0.2669 0.7135
0.0142 0.3303 0.6715
0.1282 0.5198 1
0.0433 0.4548 1
0.0886 0.2801 1
0.105 0.5866 1
0.0146 1 0.5
0.0165 0.6828 1
0.0125 0.8762 1
0.0173 0.5 0.5
0.0147 0.6608 1
0.1477 1 1
0.0173 1 1
0.0882 0.3343 1
0.1797 1 1
0.0173 0.5 0.5
0.0147 0.684 1
0.1133 0.3368 1
0.0346 0.6964 0.8582
0.2361 0.4101 1
0.1507 0.401 0.6181
0.0157 0.6608 1
0.1044 1 1
0.014 0.347 1
0.15 0.5 0.5
0.0159 0.3894 1
0.1346 0.2637 0.631
0.0151 0.3196 1
0.0903 0.6201 1
0.044 1 1
0.0156 0.5645 1
0.0346 0.3339 0.5
0.0147 0.6608 1
0.0573 0.5299 0.5421
0.0173 0.4762 0.5
0.0619 1 1
0.2301 0.3952 1
0.2481 0.4173 1
0.0173 0.5585 0.5585
0.0346 0.6585 0.5
0.178 1 1
0.1605 1 1
0.0346 0.3339 0.5
0.0173 0.8855 1
0.0173 0.3528 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.10.13680 (Trypanosoma brucei), lipase domain protein, putative
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