Detailed view for Tb927.8.2110

Basic information

TDR Targets ID: 17989
Trypanosoma brucei, Alpha/beta hydrolase family, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.5793 | Length (AA): 357 | MW (Da): 40268 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF12697   Alpha/beta hydrolase family

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile Bloodstream Form. Siegel TN
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile Procyclic. Siegel TN
Show/Hide expression data references
  • Siegel TN Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites.

Orthologs

Ortholog group members (OG5_127681)

Species Accession Gene Product
Arabidopsis thaliana AT4G24160   lysophosphatidic acid acyltransferase
Brugia malayi Bm1_20485   hydrolase, alpha/beta fold family protein
Candida albicans CaO19.7166   induced during aerobic growth
Candida albicans CaO19.11686   Induced during aerobic growth
Candida albicans CaO19.4210   Induced during aerobic growth
Candida albicans CaO19_7166   hypothetical protein
Caenorhabditis elegans CELE_C25A1.12   Protein C25A1.12
Caenorhabditis elegans CELE_C37H5.2   Protein C37H5.2
Caenorhabditis elegans CELE_C37H5.3   Protein C37H5.3, isoform B
Drosophila melanogaster Dmel_CG1882   CG1882 gene product from transcript CG1882-RG
Echinococcus granulosus EgrG_000684300   abhydrolase domain containing protein
Echinococcus multilocularis EmuJ_000684300   abhydrolase domain containing protein
Homo sapiens 51099   abhydrolase domain containing 5
Homo sapiens 63874   abhydrolase domain containing 4
Leishmania braziliensis LbrM.23.0160   hypothetical protein, conserved
Leishmania donovani LdBPK_230160.1   Alpha/beta hydrolase family, putative
Leishmania infantum LinJ.23.0160   hypothetical protein, conserved
Leishmania major LmjF.23.0140   hypothetical protein, conserved
Leishmania mexicana LmxM.23.0140   hypothetical protein, conserved
Loa Loa (eye worm) LOAG_13569   hydrolase
Mus musculus ENSMUSG00000032540   abhydrolase domain containing 5
Mus musculus ENSMUSG00000040997   abhydrolase domain containing 4
Oryza sativa 4347605   Os09g0520200
Onchocerca volvulus OVOC177  
Plasmodium falciparum PF3D7_0301300   epoxide hydrolase 1
Saccharomyces cerevisiae YGR110W   Cld1p
Saccharomyces cerevisiae YLR099C   lysophosphatidic acid acyltransferase ICT1
Schistosoma japonicum Sjp_0120940   expressed protein
Schistosoma japonicum Sjp_0085000   Abhydrolase domain-containing protein 4, putative
Schistosoma mansoni Smp_145880   hydrolase
Schmidtea mediterranea mk4.015060.00   AT25873p
Schmidtea mediterranea mk4.016223.00   AT25873p
Schmidtea mediterranea mk4.012942.00   AT25873p
Schmidtea mediterranea mk4.022943.00   AT25873p
Schmidtea mediterranea mk4.000264.04   AT25873p
Schmidtea mediterranea mk4.000264.13   AT25873p
Trypanosoma brucei Tb927.8.2110   Alpha/beta hydrolase family, putative
Trypanosoma congolense TcIL3000_8_2110   hypothetical protein, conserved

Essentiality

Tb927.8.2110 has direct evidence of essentiality
Gene/Ortholog Organism Phenotype Source Study
Tb927.8.2110 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.8.2110 this record Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.8.2110 this record Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.8.2110 this record Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
cell proliferation (GO:0008283) normal (PATO:0000461) bloodstream stage trypomastigotes (PLO:0027) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). References: 21363968
cell proliferation (GO:0008283) normal (PATO:0000461) procyclic (PLO:0034) inferred from RNAi experiment (ECO:0000019) No drug identifiers listed for this gene.
Annotator: fernan@iib.unsam.edu.ar. Comment: normal cell proliferation (no significant loss or gain of fitness) in differentiation of procyclic to bloodstream forms . References: 21363968

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens abhydrolase domain containing 5 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0038 0.7124 0.5

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Tb927.8.2110 (Trypanosoma brucei), Alpha/beta hydrolase family, putative
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