pI: 7.2593 |
Length (AA): 309 |
MW (Da): 33443 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 2 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
9 | 283 | 1v4n (A) | 7 | 271 | 43.00 | 0 | 1 | 1.43497 | -0.86 |
12 | 302 | 4glj (A) | 15 | 297 | 43.00 | 0 | 1 | 1.51875 | -0.88 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_128424)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_42810 | MTAP |
Candida albicans | CaO19.14200 | ADH2 expression |
Candida albicans | CaO19.6938 | ADH2 expression |
Caenorhabditis elegans | CELE_B0228.7 | Protein B0228.7 |
Drosophila melanogaster | Dmel_CG4802 | Methylthioadenosine phosphorylase ortholog |
Echinococcus granulosus | EgrG_000622900 | methylthioadenosine phosphorylase |
Echinococcus multilocularis | EmuJ_000622900 | methylthioadenosine phosphorylase |
Homo sapiens | ENSG00000099810 | methylthioadenosine phosphorylase |
Leishmania braziliensis | LbrM.05.0800 | methylthioadenosine phosphorylase, putative |
Leishmania donovani | LdBPK_050830.1 | methylthioadenosine phosphorylase, putative |
Leishmania infantum | LinJ.05.0830 | methylthioadenosine phosphorylase, putative |
Leishmania major | LmjF.05.0830 | methylthioadenosine phosphorylase, putative |
Leishmania mexicana | LmxM.05.0830 | methylthioadenosine phosphorylase, putative |
Loa Loa (eye worm) | LOAG_01831 | S-methyl-5'-thioadenosine phosphorylase MTAP |
Mus musculus | ENSMUSG00000062937 | methylthioadenosine phosphorylase |
Mycobacterium tuberculosis | Rv0535 | Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) |
Mycobacterium ulcerans | MUL_0634 | 5'-methylthioadenosine phosphorylase |
Saccharomyces cerevisiae | YLR017W | S-methyl-5-thioadenosine phosphorylase |
Schistosoma japonicum | Sjp_0213000 | ko:K00772 5'-methylthioadenosine phosphorylase [EC2.4.2.28], putative |
Schistosoma mansoni | Smp_102440 | methylthioadenosine phosphorylase |
Schistosoma mansoni | Smp_028190 | methylthioadenosine phosphorylase |
Schmidtea mediterranea | mk4.006248.03 | S-methyl-5'-thioadenosine phosphorylase |
Trypanosoma brucei gambiense | Tbg972.7.8280 | methylthioadenosine phosphorylase, putative |
Trypanosoma brucei | Tb927.7.7040 | methylthioadenosine phosphorylase, putative |
Trypanosoma congolense | TcIL3000_7_5710 | methylthioadenosine phosphorylase, putative |
Trypanosoma cruzi | TcCLB.506789.280 | methylthioadenosine phosphorylase, putative |
Trypanosoma cruzi | TcCLB.508387.20 | methylthioadenosine phosphorylase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.7.7040 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.7040 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.7040 this record | Trypanosoma brucei | significant gain of fitness in procyclic forms | alsford |
Tb927.7.7040 this record | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | increased (PATO:0000470) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | increased cell proliferation (significant gain of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.8
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | methylthioadenosine phosphorylase | Compounds | References |
Mus musculus | methylthioadenosine phosphorylase | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Purine-nucleoside phosphorylase | 289 aa | 23.2% | 276 aa | Compounds | References |
Bos taurus | Purine nucleoside phosphorylase | 289 aa | 24.5% | 277 aa | Compounds | References |
1 literature reference was collected for this gene.