pI: 11.89 |
Length (AA): 118 |
MW (Da): 12302 |
Paralog Number:
3
Signal peptide: Y | GPI Anchor: | Predicted trans-membrane segments: 2
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | Procyclic, Bloodstream Form. | Siegel TN |
Siegel TN | Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites. |
Ortholog group members (OG5_126818)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | ArthMp094 | ATPase subunit 9 |
Arabidopsis thaliana | ArthCp009 | ATPase III subunit |
Arabidopsis thaliana | AT2G07671 | ATP synthase subunit C family protein |
Babesia bovis | BBOV_III004620 | ATP synthase subunit C family protein |
Brugia malayi | Bm1_47320 | ATP synthase lipid-binding protein, mitochondrial precursor |
Candida albicans | CaalfMp05 | ATPase subunit 9 |
Caenorhabditis elegans | CELE_Y82E9BR.3 | Protein Y82E9BR.3 |
Dictyostelium discoideum | DidioMp16 | ATPase subunit 9 |
Drosophila melanogaster | Dmel_CG1746 | CG1746 gene product from transcript CG1746-RA |
Escherichia coli | b3737 | F0 sector of membrane-bound ATP synthase, subunit c |
Echinococcus granulosus | EgrG_001064800 | mitochondrial ATP synthase subunit 9 |
Echinococcus multilocularis | EmuJ_001064800 | mitochondrial ATP synthase subunit 9 |
Homo sapiens | ENSG00000159199 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) |
Homo sapiens | ENSG00000135390 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) |
Homo sapiens | 518 | ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9) |
Leishmania braziliensis | LbrM.21.0820 | ATPase subunit 9, putative |
Leishmania braziliensis | LbrM.26.0480 | ATPase subunit 9, putative |
Leishmania donovani | LdBPK_210820.1 | ATPase subunit 9, putative |
Leishmania donovani | LdBPK_260450.1 | ATPase subunit 9, putative |
Leishmania donovani | LdBPK_240640.1 | ATPase subunit 9, putative |
Leishmania infantum | LinJ.21.0820 | ATPase subunit 9, putative |
Leishmania infantum | LinJ.24.0640 | ATPase subunit 9, putative |
Leishmania major | LmjF.24.0630 | ATPase subunit 9, putative |
Leishmania major | LmjF.21.0740 | ATPase subunit 9, putative |
Leishmania major | LmjF.26.0460 | ATPase subunit 9, putative |
Leishmania mexicana | LmxM.21.0740 | ATPase subunit 9, putative |
Leishmania mexicana | LmxM.26.0460 | ATPase subunit 9, putative |
Mycobacterium leprae | ML1140 | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) |
Mus musculus | ENSMUSG00000018770 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9) |
Mus musculus | ENSMUSG00000062683 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C2 (subunit 9) |
Mus musculus | 11951 | ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9) |
Mycobacterium tuberculosis | Rv1305 | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) |
Mycobacterium ulcerans | MUL_3959 | F0F1 ATP synthase subunit C |
Neospora caninum | NCLIV_065850 | ATP synthase lipid-binding protein, putative |
Oryza sativa | 6450130 | ATP synthase F0 subunit 9 |
Oryza sativa | 3131392 | ATPase III subunit |
Plasmodium berghei | PBANKA_0803500 | ATP synthase subunit C, putative |
Plasmodium falciparum | PF3D7_0705900 | ATP synthase subunit C, putative |
Plasmodium knowlesi | PKNH_0104400 | ATPase subunit 9, putative |
Plasmodium vivax | PVX_087835 | ATP synthase lipid-binding protein, mitochondrial precursor, putative |
Plasmodium yoelii | PY03813 | ATPase subunit 9, putative |
Saccharomyces cerevisiae | Q0130 | F0 ATP synthase subunit C |
Schistosoma japonicum | Sjp_0205580 | ko:K02128 F-type H+-transporting ATPase subunit c, putative |
Schistosoma mansoni | Smp_000880.1 | ATP synthase lipid-binding protein-like protein |
Schistosoma mansoni | Smp_000880.2 | ATP synthase lipid-binding protein-like protein |
Schmidtea mediterranea | mk4.000902.01 | ATP synthase lipid-binding protein, mitochondrial |
Schmidtea mediterranea | mk4.009442.00 | ATP synthase lipid-binding protein, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.7.1470 | ATPase subunit 9, putative |
Trypanosoma brucei gambiense | Tbg972.10.1860 | ATPase subunit 9, putative |
Trypanosoma brucei gambiense | Tbg972.11.5960 | ATPase subunit 9, putative |
Trypanosoma brucei | Tb927.11.5280 | Mitochondrial ATP synthase subunit c-1 |
Trypanosoma brucei | Tb927.10.1570 | Mitochondrial ATP synthase subunit c-2 |
Trypanosoma brucei | Tb927.8.595 | hypothetical protein |
Trypanosoma brucei | Tb927.7.1470 | Mitochondrial ATP synthase subunit c-3 |
Trypanosoma congolense | TcIL3000_7_970 | ATPase subunit 9, putative |
Trypanosoma cruzi | TcCLB.507517.60 | ATPase subunit 9, putative |
Trypanosoma cruzi | TcCLB.503579.70 | ATPase subunit 9, putative |
Trypanosoma cruzi | TcCLB.506977.70 | ATPase subunit 9, putative |
Trypanosoma cruzi | TcCLB.504125.40 | ATPase subunit 9, putative |
Trypanosoma cruzi | TcCLB.504131.180 | ATPase subunit 9, putative |
Toxoplasma gondii | TGME49_249720 | ATP synthase F0 subunit 9, putative |
Theileria parva | TP02_0804 | ATP synthase F0, subunit C, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0459 | ATP synthase F0F1 subunit C |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
mtu1327 | Mycobacterium tuberculosis | essential | nmpdr |
Tb927.10.1570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1570 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1570 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb927.7.1470 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb927.7.1470 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.7.1470 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.7.1470 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
Tb11.02.2950 this record | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb11.02.2950 this record | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb11.02.2950 this record | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb11.02.2950 this record | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b3737 | Escherichia coli | non-essential | goodall |
CELE_Y82E9BR.3 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y82E9BR.3 | Caenorhabditis elegans | larval arrest | wormbase |
TGME49_249720 | Toxoplasma gondii | Probably essential | sidik |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
cell proliferation (GO:0008283) | normal (PATO:0000461) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in bloodstream forms (stage 3 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | bloodstream stage trypomastigotes (PLO:0027) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in bloodstream forms (stage 6 days). | References: | 21363968 | |
cell proliferation (GO:0008283) | normal (PATO:0000461) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | normal cell proliferation (no significant loss or gain of fitness) in procyclic forms . | References: | 21363968 | |
cell proliferation (GO:0008283) | decreased (PATO:0000468) | procyclic (PLO:0034) | inferred from RNAi experiment (ECO:0000019) | No drug identifiers listed for this gene. | ||
Annotator: | fernan@iib.unsam.edu.ar. | Comment: | decreased cell proliferation (significant loss of fitness) in differentiation of procyclic to bloodstream forms . | References: | 21363968 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mycobacterium smegmatis | Putative uncharacterized protein atpE | Compounds | References |
Mycobacterium tuberculosis | Probable ATP synthase C chain AtpE (lipid-binding protein) (dicyclohexylcarbodiimide-binding protein) | Compounds | References |
Mycobacterium leprae | PROBABLE ATP SYNTHASE C CHAIN ATPE (LIPID-BINDING PROTEIN) (DICYCLOHEXYLCARBODIIMIDE-BINDING PROTEIN) | Compounds | References |
38 literature references were collected for this gene.