pI: 6.583 |
Length (AA): 2375 |
MW (Da): 273438 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 21 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
472 | 657 | 1qdl (B) | 2 | 195 | 24.00 | 0 | 1 | 0.24 | -1.53 |
633 | 1090 | 1w96 (A) | 14 | 554 | 14.00 | 0 | 0.97 | -0.1 | 0.34 |
675 | 1138 | 1ulz (A) | 1 | 451 | 18.00 | 0 | 1 | 0.08 | -0.03 |
690 | 1071 | 1kjq (A) | 15 | 388 | 16.00 | 0 | 1 | 0.32 | -0.16 |
714 | 994 | 1iow () | 18 | 302 | 16.00 | 0 | 1 | 0.3 | -0.2 |
1783 | 2273 | 1w96 (A) | 15 | 556 | 15.00 | 0 | 1 | -0.03 | 0.23 |
1839 | 2307 | 1w96 (A) | 59 | 540 | 14.00 | 0 | 1 | 0.19 | -0.02 |
1909 | 2174 | 1kjq (A) | 70 | 330 | 17.00 | 0 | 1 | 0.37 | -0.58 |
65 | 663 | 1a9x (B) | 1503 | 1880 | 33.00 | 0 | 1 | -0.124189 | 1.91 |
474 | 652 | 1wl8 (A) | 3 | 182 | 21.00 | 0 | 0.99 | 0.391968 | -0.83 |
513 | 571 | 3l7n (A) | 45 | 115 | 41.00 | 0.69 | 0.76 | 0.311842 | -0.15 |
677 | 2373 | 1a9x (A) | 8 | 1073 | 33.00 | 0 | 1 | 0.0419263 | 1.86 |
689 | 1349 | 1a9x (A) | 20 | 674 | 37.00 | 0 | 1 | 0.697916 | -0.35 |
1396 | 1587 | 4tql (A) | 43 | 236 | 14.00 | 0.013 | 0.02 | 0.230442 | -0.83 |
65 | 663 | 1a9x (B) | 1503 | 1880 | 33.00 | 0 | 1 | -0.0908017 | 1.67 |
472 | 711 | 3uow (A) | 7 | 283 | 20.00 | 0.000000019 | 0.61 | 0.146168 | 0.4 |
474 | 652 | 1wl8 (A) | 3 | 182 | 21.00 | 0 | 0.98 | 0.404505 | -0.87 |
677 | 2375 | 1a9x (A) | 8 | 1073 | 32.00 | 0 | 1 | 0.0672665 | 1.76 |
689 | 1318 | 1a9x (A) | 20 | 636 | 39.00 | 0 | 1 | 0.73624 | -0.47 |
785 | 983 | 3tw6 (B) | 111 | 314 | 20.00 | 0.00036 | 1 | 0.328919 | -0.2 |
1438 | 1624 | 4uos (A) | 1 | 183 | 15.00 | 0.3 | 0.01 | 0.286871 | -1.23 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, merozoite, sporozoite, early ring, early trophozoite, late ring, late trophozoite, Ring. | Otto TD PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | early schizont, Oocyst. | PlasmoDB Zanghi G |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, late schizont, Male Gametocyte. | Otto TD PlasmoDB Lasonder E |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | Sporozoite, Female Gametocyte. | Zanghi G Lasonder E |
Zanghi G | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection. |
Otto TD | New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq. |
Lasonder E | Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression. |
PlasmoDB | Data on upregulation of P. falciparum genes in different life cycle stages, combined from several microarray experiments available in PlasmoDB |
Ortholog group members (OG5_126835)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G29900 | carbamoyl phosphate synthetase B |
Babesia bovis | BBOV_III003590 | carbamoyl phosphate synthetase |
Brugia malayi | Bm1_55375 | carbamoyl-phosphate synthase, large subunit |
Candida albicans | CaO19.9896 | aspartate transcarbamylase similar to S. cerevisiae URA2 (YJL130C) pyrimidine biosynthesis enzyme |
Candida albicans | CaO19.2360 | aspartate transcarbamylase similar to S. cerevisiae URA2 (YJL130C) pyrimidine biosynthesis enzyme |
Candida albicans | CaO19.3221 | likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis |
Candida albicans | CaO19.10732 | likely carbamoyl-phosphate synthase large subunit similar to S. cerevisiae CPA2 (YJR109C) invovled in arginine biosynthesis |
Caenorhabditis elegans | CELE_D2085.1 | Protein PYR-1 |
Dictyostelium discoideum | DDB_G0276335 | aspartate carbamoyltransferase |
Drosophila melanogaster | Dmel_CG18572 | rudimentary |
Escherichia coli | b0033 | carbamoyl-phosphate synthase large subunit |
Homo sapiens | ENSG00000021826 | carbamoyl-phosphate synthase 1, mitochondrial |
Homo sapiens | ENSG00000084774 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
Leishmania braziliensis | LbrM.16.0600 | carbamoyl-phosphate synthase, putative |
Leishmania donovani | LdBPK_160590.1 | carbamoyl-phosphate synthase, putative |
Leishmania infantum | LinJ.16.0590 | carbamoyl-phosphate synthase, putative |
Leishmania major | LmjF.16.0590 | carbamoyl-phosphate synthase, putative |
Leishmania mexicana | LmxM.16.0590 | carbamoyl-phosphate synthase, putative |
Mycobacterium leprae | ML0536 | Probable carbamoyl-phosphate synthase large subunit CarB (Carbamoyl-phosphate synthetase ammonia chain) |
Mus musculus | ENSMUSG00000013629 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
Mus musculus | ENSMUSG00000025991 | carbamoyl-phosphate synthetase 1 |
Mycobacterium tuberculosis | Rv1384 | Probable carbamoyl-phosphate synthase large chain CarB (carbamoyl-phosphate synthetase ammonia chain) |
Mycobacterium ulcerans | MUL_1784 | carbamoyl phosphate synthase large subunit |
Neospora caninum | NCLIV_052220 | hypothetical protein |
Oryza sativa | 4326346 | Os01g0570700 |
Plasmodium berghei | PBANKA_1406700 | carbamoyl phosphate synthetase, putative |
Plasmodium falciparum | PF3D7_1308200 | carbamoyl phosphate synthetase |
Plasmodium knowlesi | PKNH_1408600 | carbamoyl phosphate synthetase, putative |
Plasmodium vivax | PVX_122240 | carbamoyl phosphate synthetase, putative |
Plasmodium yoelii | PY04780 | carbamoyl phosphate synthetase II-related |
Plasmodium yoelii | PY04781 | carbamoyl phosphate synthetase II-related |
Plasmodium yoelii | PY06257 | carbamoyl phosphate synthetase II-related |
Saccharomyces cerevisiae | YJR109C | carbamoyl-phosphate synthase (glutamine-hydrolyzing) CPA2 |
Saccharomyces cerevisiae | YJL130C | bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase |
Schistosoma japonicum | Sjp_0026210 | ko:K01465 dihydroorotase [EC3.5.2.3], putative |
Schistosoma japonicum | Sjp_0080610 | CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase, putative |
Schistosoma japonicum | Sjp_0026200 | ko:K00609 aspartate carbamoyltransferase catalytic chain [EC2.1.3.2C], putative |
Schistosoma mansoni | Smp_186670 | carbamoyl-phosphate synthetase |
Schistosoma mansoni | Smp_106150 | aspartate carbamoyltransferase |
Schmidtea mediterranea | mk4.003398.06 | |
Schmidtea mediterranea | mk4.035059.00 | CAD protein |
Schmidtea mediterranea | mk4.015554.00 | |
Schmidtea mediterranea | mk4.032484.00 | |
Schmidtea mediterranea | mk4.003398.05 | CAD protein |
Schmidtea mediterranea | mk4.016070.00 | |
Schmidtea mediterranea | mk4.014140.00 | |
Trypanosoma brucei gambiense | Tbg972.5.5270 | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative |
Trypanosoma brucei | Tb927.5.3800 | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative |
Trypanosoma congolense | TcIL3000_5_4250 | glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative |
Trypanosoma cruzi | TcCLB.507059.80 | glutamine-dependent carbamoyl-phosphate synthetase, putative |
Trypanosoma cruzi | TcCLB.511647.4 | glutamine-dependent carbamoyl-phosphate synthetase, putative |
Trypanosoma cruzi | TcCLB.508373.10 | glutamine dependent carbamoyl-phosphate synthase, putative |
Toxoplasma gondii | TGME49_215260 | carbamoylphosphate synthetase |
Theileria parva | TP03_0048 | glutamine-dependent carbamoyl phosphate synthase, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0512 | carbamoyl phosphate synthase large subunit |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.5.3800 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.5.3800 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.5.3800 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.5.3800 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
b0033 | Escherichia coli | non-essential | goodall |
CELE_D2085.1 | Caenorhabditis elegans | embryonic arrest | wormbase |
CELE_D2085.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_D2085.1 | Caenorhabditis elegans | larval lethal | wormbase |
CELE_D2085.1 | Caenorhabditis elegans | slow growth | wormbase |
PBANKA_1406700 | Plasmodium berghei | Essential | plasmo |
TGME49_215260 | Toxoplasma gondii | Essentiality uncertain | sidik |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Drugs/Inhibitors |
---|---|---|---|---|---|---|
growth (GO:0040007) | lethal (sensu genetics) (PATO:0000718) | multi-cellular organism (CARO:0000012) | bloodstream stage (PLO:0040) | in vivo inhibition (TDR:00016) | Plasmodium falciparum | No drug identifiers listed for this gene. |
Annotator: | saralph@unimelb.edu.au. | Comment: | Drug: phosphorothioated hammerhead ribozymes. . | References: | 9202005 9562429 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.7
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase | Compounds | References |
5 literature references were collected for this gene.