pI: 5.3415 |
Length (AA): 1109 |
MW (Da): 122083 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 8
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 5 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
82 | 1024 | 1wpg (A) | 2 | 991 | 29.00 | 0 | 1 | 1.25 | -0.97 |
82 | 1026 | 2o9j (A) | 2 | 993 | 29.00 | 0 | 1 | 1.11662 | 0.23 |
480 | 645 | 3gwi (A) | 396 | 545 | 25.00 | 0 | 0.97 | 0.394184 | -0.31 |
701 | 783 | 4dw8 (A) | 184 | 255 | 36.00 | 0.043 | 0.43 | 0.238242 | 0.47 |
713 | 794 | 1wr8 (A) | 142 | 223 | 24.00 | 0 | 0.23 | 0.24944 | 0.64 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Mid 40-60% percentile | metacyclic. | Fernandes MC |
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Lower 20-40% percentile | amastigotes. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128979)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV010020 | P-type ATPase4, putative |
Candida albicans | CaO19.12637 | P-type Na+ATPase |
Candida albicans | CaO19.13491 | P-type ATPase, Na+ efflux |
Candida albicans | CaO19.6070 | P-type ATPase, Na+ efflux |
Candida albicans | CaO19.5170 | P-type Na+ATPase |
Candida albicans | CaO19_5170 | hypothetical protein |
Cryptosporidium hominis | Chro.40306 | ATPase |
Cryptosporidium parvum | cgd4_2720 | P-type ATpase involved in cation transport |
Entamoeba histolytica | EHI_027710 | calcium-transporting P-type ATPase, putative |
Leishmania braziliensis | LbrM.34.1990 | calcium motive p-type ATPase, putative |
Leishmania donovani | LdBPK_352080.1 | calcium motive p-type ATPase, putative |
Leishmania infantum | LinJ.35.2080 | calcium motive p-type ATPase, putative |
Leishmania major | LmjF.35.2080 | calcium motive p-type ATPase, putative |
Leishmania mexicana | LmxM.34.2080 | calcium motive p-type ATPase, putative |
Neospora caninum | NCLIV_067350 | P-type Ca(2 )-ATPase, putative |
Saccharomyces cerevisiae | YDR038C | putative Na(+)-exporting P-type ATPase ENA5 |
Saccharomyces cerevisiae | YDR039C | Na(+)-exporting P-type ATPase ENA2 |
Saccharomyces cerevisiae | YDR040C | Na(+)/Li(+)-exporting P-type ATPase ENA1 |
Trypanosoma brucei gambiense | Tbg972.9.9590 | calcium motive p-type ATPase, putative |
Trypanosoma brucei | Tb927.9.15460 | calcium motive p-type ATPase, putative |
Trypanosoma cruzi | TcCLB.506241.70 | calcium motive p-type ATPase, putative |
Trypanosoma cruzi | TcCLB.510769.120 | calcium motive p-type ATPase, putative |
Toxoplasma gondii | TGME49_278660 | P-type ATPase4, putative |
Theileria parva | TP01_0720 | P-type ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.244.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb09.244.2570 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb09.244.2570 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb09.244.2570 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
TGME49_278660 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.5
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 1103 aa | 24.9% | 1004 aa | Compounds | References |
Trypanosoma cruzi | P-type H+-ATPase, putative | 645 aa | 25.4% | 735 aa | Compounds | References |
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 1043 aa | 29.4% | 995 aa | Compounds | References |
Oryctolagus cuniculus | Sarcoplasmic/endoplasmic reticulum calcium ATP-ase | 1001 aa | 29.8% | 982 aa | Compounds | References |
Trypanosoma cruzi | P-type H+-ATPase, putative | 259 aa | 30.1% | 216 aa | Compounds | References |
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 994 aa | 29.4% | 978 aa | Compounds | References |
Trypanosoma cruzi | plasma membrane Ca2+ ATPase | 1101 aa | 24.7% | 1004 aa | Compounds | References |
2 literature references were collected for this gene.