Detailed view for LmjF.09.1450

Basic information

TDR Targets ID: 20920
Leishmania major, hypothetical protein, conserved
Source Database / ID:  TriTrypDB  GeneDB

pI: 8.3283 | Length (AA): 131 | MW (Da): 15030 | Paralog Number: 2

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00581   Rhodanese-like domain

Gene Ontology

Mouse over links to read term descriptions.
No GO information for this protein.

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 5 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
3 125 2hhg (A) 13 129 16.00 0 0.88 1.26 -1.3
13 121 1urh (A) 6 127 17.00 0 1 1.03 -1.72
2 127 3tp9 (A) 362 470 23.00 0.00028 1 1.12073 0.04
10 128 3d1p (A) 22 138 24.00 0 1 1.271 -0.86
31 113 2jtq (A) 3 73 23.00 0 0.82 0.741188 -0.12

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes. Fernandes MC
Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127795)

Species Accession Gene Product
Arabidopsis thaliana AT1G79230   mercaptopyruvate sulfurtransferase 1
Candida albicans CaO19.2363   potential mitochondrial rhodanese-like protein similar to S. cerevisiae FMP31 (YOR286W)
Candida albicans CaO19.9899   potential mitochondrial rhodanese-like protein similar to S. cerevisiae FMP31 (YOR286W) and to YOR285W
Dictyostelium discoideum DDB_G0267698   hypothetical protein
Dictyostelium discoideum DDB_G0277009   hypothetical protein
Drosophila melanogaster Dmel_CG12279   CG12279 gene product from transcript CG12279-RA
Drosophila melanogaster Dmel_CG6000   CG6000 gene product from transcript CG6000-RD
Echinococcus granulosus EgrG_000663100   heat shock protein 67b2
Echinococcus multilocularis EmuJ_000663100   heat shock protein 67b2
Homo sapiens 100130890   thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
Homo sapiens ENSG00000215845   thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
Leishmania braziliensis LbrM.09.1530   hypothetical protein, conserved
Leishmania braziliensis LbrM.09.1520   hypothetical protein, conserved
Leishmania braziliensis LbrM.09.1510   hypothetical protein, conserved
Leishmania donovani LdBPK_091550.1   hypothetical protein, conserved
Leishmania donovani LdBPK_091540.1   hypothetical protein, conserved
Leishmania donovani LdBPK_091530.1   hypothetical protein, conserved
Leishmania infantum LinJ.09.1550   hypothetical protein, conserved
Leishmania infantum LinJ.09.1540   hypothetical protein, conserved
Leishmania infantum LinJ.09.1530   hypothetical protein, conserved
Leishmania major LmjF.09.1460   hypothetical protein, conserved
Leishmania major LmjF.09.1470   hypothetical protein, conserved
Leishmania major LmjF.09.1450   hypothetical protein, conserved
Leishmania mexicana LmxM.09.1470   hypothetical protein, conserved
Leishmania mexicana LmxM.09.1460   hypothetical protein, conserved
Leishmania mexicana LmxM.09.1450   hypothetical protein, conserved
Mus musculus ENSMUSG00000028251   thiosulfate sulfurtransferase (rhodanese)-like domain containing 3
Mus musculus ENSMUSG00000103711   thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
Saccharomyces cerevisiae YOR285W   Rdl1p
Saccharomyces cerevisiae YOR286W   Rdl2p
Schistosoma japonicum Sjp_0130080   Heat shock protein 67B2, putative
Schistosoma japonicum Sjp_0022500   ko:K01010 thiosulfate sulfurtransferase [EC2.8.1.1], putative
Schistosoma mansoni Smp_007450.2   hypothetical protein
Schistosoma mansoni Smp_006560   hypothetical protein
Schistosoma mansoni Smp_007450.1   hypothetical protein
Schmidtea mediterranea mk4.006224.02  
Schmidtea mediterranea mk4.005066.02   Sulfurtransferase
Schmidtea mediterranea mk4.001140.02   Sulfurtransferase
Schmidtea mediterranea mk4.040091.00   Sulfurtransferase
Schmidtea mediterranea mk4.030239.02  
Trypanosoma brucei gambiense Tbg972.11.15200   hypothetical protein, conserved
Trypanosoma brucei gambiense Tbg972.11.15190   hypothetical protein, conserved
Trypanosoma brucei Tb927.11.13620   rhodanese-like domain containing protein, putative
Trypanosoma brucei Tb927.11.13610   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.506753.140   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.506753.150   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.510357.40   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.510357.30   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.510357.20   rhodanese-like domain containing protein, putative
Trypanosoma cruzi TcCLB.506753.130   rhodanese-like domain containing protein, putative

Essentiality

LmjF.09.1450 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb11.01.5200 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5200 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5200 Trypanosoma brucei significant gain of fitness in procyclic forms alsford
Tb11.01.5200 Trypanosoma brucei no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms alsford
Tb11.01.5195 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb11.01.5195 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb11.01.5195 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb11.01.5195 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

No enough druggable targets predicted through repurposing network model to make a plot

Putative Drugs List

Compound Raw Global Species
0.0005 0.3625 0.3625

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier LmjF.09.1450 (Leishmania major), hypothetical protein, conserved
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