Detailed view for LmjF.22.1360

Basic information

TDR Targets ID: 22228
Leishmania major, farnesyl pyrophosphate synthase
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.6024 | Length (AA): 362 | MW (Da): 40967 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00348   Polyprenyl synthetase

Gene Ontology

Mouse over links to read term descriptions.
GO:0008299   isoprenoid biosynthetic process  

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 362 1yhl (A) 1 362 64.00 0 1 1.97 -2.49
2 362 4jzx (A) 2 362 99.99 0 1 2.25374 -1.64

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

PDB tag
  • 4JZB:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4JZX:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date
PDB tag
  • 4K10:
  • Resolution Method # Atoms # Residues Dep. Date Pub. Date Mod. Date

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_127590)

Species Accession Gene Product
Arabidopsis thaliana AT4G17190   farnesyl diphosphate synthase 2
Arabidopsis thaliana AT5G47770   farnesyl diphosphate synthase 1
Babesia bovis BBOV_I000120   farnesyl pyrophosphate synthetase, putative
Brugia malayi Bm1_54695   Polyprenyl synthetase family protein
Candida albicans CaO19.11967   similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
Candida albicans CaO19.4491   similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase)
Caenorhabditis elegans CELE_R06C1.2   Protein FDPS-1
Cryptosporidium hominis Chro.40285   farnesyl pyrophosphate synthase
Cryptosporidium parvum cgd4_2550   putative farnesyl pyrophosphate synthase
Dictyostelium discoideum DDB_G0268742   hypothetical protein
Dictyostelium discoideum DDB_G0278735   FDP synthase
Dictyostelium discoideum DDB_G0278823   hypothetical protein
Drosophila melanogaster Dmel_CG12389   Farnesyl pyrophosphate synthase
Echinococcus granulosus EgrG_001040000   farnesyl pyrophosphate synthase
Echinococcus multilocularis EmuJ_001040000   farnesyl pyrophosphate synthase
Giardia lamblia GL50803_6633   Farnesyl diphosphate synthase
Homo sapiens ENSG00000160752   farnesyl diphosphate synthase
Leishmania braziliensis LbrM.22.1240   farnesyl pyrophosphate synthase
Leishmania donovani LdBPK_221210.1   farnesyl pyrophosphate synthase
Leishmania infantum LinJ.22.1210   farnesyl pyrophosphate synthase
Leishmania major LmjF.22.1360   farnesyl pyrophosphate synthase
Leishmania mexicana LmxM.22.1360   farnesyl pyrophosphate synthase, putative
Loa Loa (eye worm) LOAG_06272   polyprenyl synthetase
Mus musculus ensembl-mmu:ENSMUSG00000059743   farnesyl diphosphate synthetase
Mycobacterium tuberculosis Rv2173   Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase)
Mycobacterium ulcerans MUL_0373   geranylgeranyl pyrophosphate synthase
Mycobacterium ulcerans MUL_3516   geranylgeranyl pyrophosphate synthase
Neospora caninum NCLIV_048200   hypothetical protein
Oryza sativa 4337261   Os04g0657300
Oryza sativa 4337260   Os04g0657100
Oryza sativa 4324245   Os01g0703400
Oryza sativa 4339489   Os05g0543400
Plasmodium berghei PBANKA_0919800   geranylgeranyl pyrophosphate synthase, putative
Plasmodium falciparum PF3D7_1128400   geranylgeranyl pyrophosphate synthase, putative
Plasmodium knowlesi PKNH_0926500   geranylgeranyl pyrophosphate synthase, putative
Plasmodium vivax PVX_092040   geranylgeranyl pyrophosphate synthase
Plasmodium yoelii PY05919   farnesyl pyrophosphate synthase
Saccharomyces cerevisiae YJL167W   bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
Schistosoma japonicum Sjp_0216390   ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative
Schistosoma mansoni Smp_070710   farnesyl pyrophosphate synthase
Schmidtea mediterranea mk4.033514.01  
Schmidtea mediterranea mk4.003779.02   Farnesyl pyrophosphate synthase
Schmidtea mediterranea mk4.025052.00  
Trypanosoma brucei gambiense Tbg972.7.3690   farnesyl pyrophosphate synthase, putative
Trypanosoma brucei Tb927.7.3360   farnesyl pyrophosphate synthase
Trypanosoma congolense TcIL3000_7_2560   farnesyl pyrophosphate synthase
Trypanosoma cruzi TcCLB.511823.70   farnesyl pyrophosphate synthase
Trypanosoma cruzi TcCLB.508323.9   farnesyl pyrophosphate synthase, putative
Toxoplasma gondii TGME49_224490   polyprenyl synthetase superfamily protein
Theileria parva TP03_0857   farnesyl pyrophosphate synthetase, putative
Trichomonas vaginalis TVAG_150090   geranylgeranyl pyrophosphate synthase, putative
Trichomonas vaginalis TVAG_388030   geranylgeranyl pyrophosphate synthase, putative
Trichomonas vaginalis TVAG_353270   geranylgeranyl diphosphate synthase, putative

Essentiality

LmjF.22.1360 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (3 days) alsford
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in bloodstream forms (6 days) alsford
Tb927.7.3360 Trypanosoma brucei no significant loss or gain of fitness in procyclic forms alsford
Tb927.7.3360 Trypanosoma brucei significant gain of fitness in differentiation of procyclic to bloodstream forms alsford
CELE_R06C1.2 Caenorhabditis elegans embryonic lethal wormbase
CELE_R06C1.2 Caenorhabditis elegans larval arrest wormbase
CELE_R06C1.2 Caenorhabditis elegans sterile wormbase
YJL167W Saccharomyces cerevisiae inviable yeastgenome
PBANKA_0919800 Plasmodium berghei Essential plasmo
TGME49_224490 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity Phenotypic quality Occurs in Occurs at Evidence Observed in Drugs/Inhibitors
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania donovani 27181   335042   335833   335834   530570   534274   536350   536351   570944  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates; Drug: 109552-15-0; Drug: (Alendronate) 129318-43-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; . References: 11850291
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania donovani 27181   335042   335833   335834   530570   534274   536350   536351   570944  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates; Drug: 109552-15-0; Drug: (Alendronate) 129318-43-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; . References: 11850291
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) host (GO:0018995) Leishmania amazonensis 27181   335833   570944  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates; Drug: 109552-15-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; . References: 12089677
growth (GO:0040007) decreased time (PATO:0000716) single cell organism (CARO:0000064) amastigote (BTO:0000062) inferred from bioassay (ECO:0000094) Leishmania amazonensis 27181   335833   570944  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates; Drug: 109552-15-0. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, homologue LmjF22.1360) inhibitors leads to slow growth of Leishmania sp. in vivo (balb/c mouse lesions); Q0GKD7_LEIDO; . References: 12089677
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from in-silico analysis (ECO:0000043) Leishmania major No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, LmjF22.1360) inhibitors (designed via comparative molecular similarity indices analysis [COMSIA]) leads to reduced enzyme activity in vitro; Bisphosphonate class. References: 14613320 15828834
catalytic activity (GO:0003824) decreased (PATO:0000468) in vitro (MI:0492) inferred from specific protein inhibition (ECO:0000020) Leishmania major No drug identifiers listed for this gene.
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates. chemical inhibition with farnesyl pyrophosphate synthase (2.5.1.10, LmjF22.1360) inhibitors (designed via comparative molecular similarity indices analysis [COMSIA]) leads to reduced enzyme activity in vitro; Bisphosphonate class. References: 14613320 15828834
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from over expression (ECO:0000120) Leishmania major 335042   530570   534274  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates. overexpression of recombinant enzyme confers resistance to FPPS inhibitors; . References: 16835450
growth (GO:0040007) drug insensitive (PATO:0000528) single cell organism (CARO:0000064) promastigote (BTO:0001124) inferred from bioassay (ECO:0000094) Leishmania major 335042   530570   534274  
Annotator: aaronjr@u.washington.edu. Comment: Drug: Bisphosphonates. overexpression of recombinant enzyme confers resistance to FPPS inhibitors; . References: 16835450

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

  • Validation: inhibited in cell-free system
  • annotated by: aaronjr@u.washington.edu.
  • References: 14613320 15828834
  • Validation: inhibition during in vitro culture
  • annotated by: aaronjr@u.washington.edu.
  • References: 11300872 16835450
  • Validation: in vivo inhibition
  • annotated by: aaronjr@u.washington.edu.
  • References: 11850291 12089677

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.8

Known modulators for this target

Compound Source Reference
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
Curated by TDRTargets References
ChEMBL23 References

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Compounds References
Toxoplasma gondii polyprenyl synthetase superfamily protein Compounds References
Trypanosoma cruzi farnesyl pyrophosphate synthase Compounds References
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Compounds References
Leishmania donovani farnesyl pyrophosphate synthase Compounds References
Homo sapiens farnesyl diphosphate synthase Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.1465 0.907 1
0.1235 0.3454 1
0.1416 0.2619 0.4331
0.1146 0.7755 1
0.0996 1 1
0.2567 1 1
0.0325 0.4707 0.4707
0.0657 0.4963 0.4963
0.0404 1 1
0.0852 1 1
0.1079 1 1
0.1373 1 1
0.0201 0.3187 1
0.0408 1 1
0.0248 0.5 0.5
0.1139 0.3333 1
0.0257 0.6456 0.507
0.1765 1 1
0.0917 1 1
0.0643 0.6515 1
0.0124 0.7705 0.5
3.003 1 1
0.0435 0.8219 0.8193
0.0279 1 1
0.0759 1 1
0.2124 0.6929 0.6929
0.0717 0.4095 1
0.0302405 0.5 0.5
0.0248 1 1
0.0318 0.3934 1
0.0927 1 1
0.0124 0.4335 1
0.1694 1 1
0.0422 0.9943 0.9938
0.0235 0.5551 0.7406
0.0124 0.3901 1
0.0123843 0.5 0.5
0.1986 1 1
0.099 1 1
0.0225 0.7347 1
0.0155 0.4556 0.4556
0.0577 0.5 0.5
0.0146 0.3261 0.5992
0.0227 1 1
0.0124 1 1
0.1208 1 1
0.0396 0.9527 0.9216
0.5886 0.5834 1
0.0696 0.5 0.5
0.0448 0.7093 0.67
3.003 1 1
0.0935 0.2503 1
0.0451 1 1
0.1017 0.7114 0
0.3518 0.7875 1
0.3518 0.7875 1
0.0331 1 1
0.0349 0.3549 0.5
0.1167 1 1
0.0758 0.3193 0.5225
0.0536 0.517 0.768
0.1704 1 1
0.4245 0.4145 0.8746
0.8728 0.3979 0.9566
0.0103 0.4084 1
0.0895 1 1
0.5712 0.5834 1
0.2572 1 1
0.0155093 1 1
0.088 1 1
0.1951 1 1
0.0999 0.907 0.9031
0.0124 0.496 1
0.0432 1 1
1.1077 0.5848 1
0.0771 0.324 1
0.0915 0.4421 1
0.0112 0.3622 1
0.2097 1 1
0.0278935 0.301949 0.441965
0.1325 0.4003 1
0.1473 0.3498 1
0.1329 1 1
0.0124 1 1
0.2737 0.5976 0.5976
0.2491 1 1
0.0418 1 1
0.1024 1 1
0.0755 1 1
0.0248 0.5 0.5
0.0457 0.4877 0.8457
0.0372 0.5071 1
0.1473 0.3498 1
0.2097 1 1
0.102 0.4126 1
0.0248 0.4424 1
0.1117 1 1
0.0124 1 1
0.0106 0.3847 0.5
1.5058 0.5859 1
0.0759 1 1
0.1031 1 1
0.7031 1 1
0.2132 0.8385 1
0.0372 0.5 0.5
0.0239 1 1
0.3518 0.7875 1
0.0371528 1 1
0.1416 0.2619 0.4331
0.0199 0.5 0.5
0.1525 1 1
0.5097 1 1
0.0124 1 0.5
0.0329 0.3753 0.5756
0.1639 1 1
0.0408 0.8594 1
0.2524 1 1
0.1812 1 1
0.0344 0.3913 0.3667
0.0124 1 1
0.1478 1 1
0.0707 0.3187 1
0.0205 0.6298 1
0.1422 1 1
0.0124 0.3125 1
0.0619 0.5583 1
0.1169 1 1
0.1473 0.3498 1
0.056 0.5436 1
0.1784 0.6065 1
0.0619 0.4725 1
0.0248 1 1
0.1042 1 1
0.1152 0.2891 1
0.1416 0.2619 0.4331
0.1416 0.2619 0.4331
0.1068 1 1
0.1401 0.5624 1
0.0313 0.5716 1
0.0213 0.3615 0.3303
0.1599 0.3676 0.3762
0.0334 0.4035 1
0.2132 0.8385 1
0.0935 0.2503 1
0.1239 1 1
0.0248 0.4311 0.8541
0.0318 0.3934 1
0.1594 0.67 1
0.0247685 0.5 0.5
0.1482 1 1
0.0619 0.4725 1
0.0134 1 1
0.1186 1 1
0.0323 0.5 0.5
0.1594 0.67 1
0.0207 1 1
0.1418 1 1
0.3947 1 1
0.1473 0.3498 1
0.2737 0.5976 0.5976
0.0619 0.5583 1
0.0404 0.4737 1
0.0564 1 1
0.2132 0.8385 1
0.1465 0.907 1
0.0124 1 1
0.3102 0.5368 1
0.0124 1 1
0.1401 0.5624 1
0.0124 0.5019 1
0.1139 0.3333 1
0.0318 0.3934 1
1.6596 0.7012 1
0.1329 1 1
0.1238 1 1
0.0489 0.2703 1
0.1416 0.2619 0.4331
1.5085 1 1
1.4204 1 1
0.0248 1 1
1.4196 0.7025 1
0.0313 0.3128 0.3128
0.1421 0.5737 1
0.1809 1 1
0.0898 0.8087 0.8032
0.088 1 1
0.0963 1 1
0.0759 1 1
0.0432 1 1
0.1072 1 1
0.01 1 1
0.0099 0.4828 0.5
0.0124 0.6005 0.5
0.1321 1 1
0.1524 1 1
0.0279 1 1
0.0247685 0.5 0.5
0.0238 0.6588 0.6397
0.0457 0.4877 0.8457
0.2118 1 1
0.3102 0.5368 1
0.1321 1 1
0.1418 1 1
0.0206 1 1
0.0248 1 1
0.0671 0.6411 0.6311
0.1567 1 1
0.0456 0.4589 1
0.189 1 1
0.1946 1 1
0.0408 0.8594 1
1.4193 1 1
0.3947 1 1
0.0431 1 1
0.1599 0.3676 0.3762
0.0927 1 1
0.0101 1 1
0.0124 0.4286 0.5
0.0248 0.6539 1
0.0279 1 1
0.0858 1 1
0.1885 1 1
0.1772 1 1
0.0248 0.3458 1
0.1372 1 1
0.0753 1 1
0.0269 0.2737 0.2737
0.3789 1 1
0.0424 1 1
0.0104 0.5 0.5
0.0124 0.3325 1
0.1482 1 1
0.0876 0.5194 0.7978
1.5058 0.5859 1
0.1144 1 1
0.0768 1 1
0.0344 1 1
0.0124 0.3125 1
0.0372 0.5071 1
0.02 0.5 0.5
0.0247685 0.5 0.5
0.0536 0.517 0.768
0.0619 0.5583 1
3.003 1 1
0.0474 1 1
0.03 0.5749 1
0.0337 0.7115 1
0.1168 0.5 0.5
0.0935 0.2503 1
0.0124 0.5 0.5
0.1416 0.2619 0.4331
0.0124 1 1
0.1895 1 1
0.0421 1 1
0.0299 0.5 0.5
0.0279 1 1
0.3102 0.5368 1
0.3102 0.5368 1
0.1169 1 1
0.0279 1 1
0.0332 1 1
0.1882 1 1
0.0318 0.3934 1
0.034 0.4858 1
1.5058 0.5859 1
1.1077 0.5848 1
0.0707 0.3187 1
1.1077 0.5848 1
0.0939 0.8297 0.8289
0.0915 0.3691 1
0.0248 1 1
0.0337 1 1
0.0451 1 1
0.0778 1 1
0.0211 1 1
0.0124 0.5 0.5
0.0221 0.4868 1
0.1271 1 1
0.0372 1 1
0.0939 0.8297 0.8289
0.0318 0.3934 1
0.0546 0.6597 1
0.102 0.4126 1
0.0256 0.273 1
0.016 1 1
0.1809 1 1
0.1474 1 1
0.0362466 0.5 0.5
0.0248 0.4424 1
0.2666 0.6927 0.6925
0.0247685 0.5 0.5
1.6596 0.7012 1
0.0124 0.5329 1
0.0213 1 1
0.0238 0.5 0.5
0.0123843 0.5 0.5
0.0587 0.524 0.5078
0.0428 0.522 1
0.0247685 0.5 0.5
0.2097 1 1
0.1263 1 1
0.0372 0.5071 1
0.0278935 0.301949 0.441965
0.1758 1 1
0.033 1 1
0.3102 0.5368 1
0.0226 0.2653 1
0.1302 1 1
0.2132 0.8385 1
0.1832 1 1
0.2336 1 1
0.3342 0.7809 1
0.0251 0.2883 0.6453
0.0678 1 1
0.1416 0.2619 0.4331
0.3209 1 1
0.0248 0.7936 1
0.1146 0.3191 1
0.0778 0.5 0.5
0.2491 1 1
0.3753 0.3498 1
0.0239 0.298 1
1.3831 0.6378 1
0.8728 0.3979 0.9566
0.1547 1 1
0.1594 0.67 1
0.2737 0.5976 0.5976
0.034 0.4858 1
0.3389 1 1
0.052 0.6497 1
0.2097 1 1
0.0279 1 1
0.0902 1 1
0.031 1 1
0.0396 0.9527 0.9216
0.0213 0.2542 1
0.0876 0.5194 0.7978
0.0847 0.9725 1
0.0278935 0.301949 0.441965
0.2132 0.8385 1
0.0337 0.7115 1
0.012 1 1
0.0935 0.2503 1
0.1594 0.67 1
0.0536 0.517 0.768
0.1779 1 1
0.00611381 1 1
0.0124 0.713 1
0.1294 0.5 0.5
0.0944 1 1
0.01 0.3008 1
0.0124 1 0.5
0.1898 1 1
0.0403 1 1
0.1502 0.3989 1
0.0939 1 1
0.1295 1 1
0.0236 0.9025 1
0.031 1 1
0.0264 0.8717 0.8536
0.0247685 0.384468 0.344468
0.0536 0.517 0.768
0.0432 1 1
0.3209 1 1
0.1332 1 1
0.3102 0.5368 1
0.0403 1 1
0.1416 0.2619 0.4331
0.3102 0.5368 1
0.0403 0.5139 1
0.0266 1 1
2.5799 1 1
0.0418 0.5768 0.7518
0.0124 1 0.5
0.1765 1 1
0.2399 1 1
0.1822 1 1
0.0247685 0.384468 0.344468
0.2097 1 1
0.0312 0.6844 0.6844
0.0310185 1 1
0.0247685 0.5 0.5
0.0535 1 1
0.0952 1 1
0.1572 1 1
0.150459 0.5 0.5
0.0624 1 1
0.0235 1 1
0.0124 0.7395 1
0.0247685 0.5 0.5
0.6219 1 1
0.1031 1 1
0.0486 1 1
0.1079 1 1
0.0123843 0.5 0.5
0.0758 0.3193 0.5225
0.0428 0.3611 0.796
0.2132 0.8385 1
0.0247685 0.5 0.5
0.2 1 1
0.2572 1 1
0.0778 1 1
0.0329 0.3753 0.5756
0.1528 1 1
0.0618 0.261 0.3228
0.1913 0.5 0.5
0.1765 1 1
0.1905 1 1
0.2572 1 1
0.0326 1 1
0.0124 0.5 0.5
0.0664 0.5 0.5
0.0302 0.5 0.5
0.021 1 1
0.0124 1 1
0.1169 1 1
0.0124 0.2583 1
0.263 1 1
0.1221 0.4186 1
0.3102 0.5368 1
0.1107 1 1
1.6596 0.7012 1
0.3482 1 1
0.0811 1 1
0.1169 1 1
0.3102 0.5368 1
0.0249215 0.256643 0.236191
0.1169 1 1
0.0591 0.8033 1
0.0248 0.7936 1
0.1784 0.6065 1
0.1473 0.3498 1
0.0123843 0.5 0.5
0.0244 1 1
0.088 1 1
0.0536 0.517 0.768
0.0975 1 1
0.3102 0.5368 1
0.3102 0.5368 1
0.0414 0.82 1
0.2737 0.5976 0.5976
0.0457 0.4877 0.8457
0.0226 0.2653 1
0.2572 1 1
0.1401 0.5624 1
0.102 0.4126 1
0.1416 0.2619 0.4331
0.0305 0.5 0.5
0.1922 1 1
0.0687 0.4766 1
0.1235 0.3454 1
0.2124 0.6929 0.6929
0.0372 0.2583 0.2576
0.0124 0.5 0.5
0.0678 1 1
0.0256 0.273 1
0.0232 1 1
0.1152 0.2891 1
0.0564 1 1
0.0619 0.4725 1
0.0396 0.9527 0.9216
0.0155 0.4556 0.4556
0.1599 0.3676 0.3762
0.1401 0.5624 1
0.1153 1 1
0.0212 0.4652 1
0.2572 1 1
0.102 0.4126 1
0.0439 0.5 0.5
0.1208 1 1
0.0489 0.2703 1
0.0822 1 1
0.2491 1 1
0.2378 1 1
0.2399 1 1
0.1765 1 1
0.0281 0.4433 0.5527
0.0229 0.8541 1
0.0217 0.5586 1
0.1169 1 1
0.1465 0.907 1
0.0248 0.6976 1
0.0467 0.6622 1
0.0124 0.44 1
1.4204 1 1
0.0363166 1 1
0.1482 1 1
0.0248 0.4311 0.8541
0.1425 0.5 0.5
0.0279 1 1
0.0939 1 1
0.3518 0.7875 1
0.0124 1 1
0.1473 0.3498 1
0.2132 0.8385 1
0.0815 1 1
0.0536 0.517 0.768
0.0332 1 1
0.098 1 1
0.4495 1 1
0.4466 1 1
0.1972 1 1
0.2132 0.8385 1
0.0228 0.2707 1
0.0124 0.4608 1
1.5058 0.5859 1
0.0758 0.3193 0.5225
0.0418 0.5768 0.7518
0.0124 0.54 1
0.2052 1 1
0.0124 1 1
0.0123843 0.5 0.5
0.1416 0.2619 0.4331
0.0535 1 1
0.0372 0.2583 0.2576

Assayability

Assay information

  • ChEMBL
  • Inhibition of Leishmania major FPPS

Reagent availability

No reagent availability information for this target.

Bibliographic References

8 literature references were collected for this gene.

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Gene identifier LmjF.22.1360 (Leishmania major), farnesyl pyrophosphate synthase
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