pI: 6.4914 |
Length (AA): 254 |
MW (Da): 28105 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 8 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
1 | 254 | 1h5q (A) | 7 | 262 | 22.00 | 0 | 1 | 1.2 | -0.74 |
2 | 251 | 1iy8 (A) | 10 | 262 | 20.00 | 0 | 1 | 1.21 | -1.24 |
2 | 254 | 1n5d (A) | 1 | 276 | 36.00 | 0 | 1 | 1.36 | -0.74 |
1 | 254 | 1h5q (A) | 7 | 262 | 22.00 | 0 | 1 | 1.2214 | -0.34 |
5 | 212 | 3gk3 (A) | 4 | 191 | 28.00 | 0.000034 | 1 | 1.0615 | -0.13 |
5 | 90 | 4o6v (A) | 4 | 83 | 33.00 | 0.084 | 0.94 | 0.743183 | -1.11 |
6 | 93 | 3uxy (A) | 7 | 83 | 40.00 | 0.68 | 1 | 0.695057 | -0.29 |
7 | 254 | 1wma (A) | 6 | 276 | 36.00 | 0 | 1 | 1.33298 | -0.87 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 60-80% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_128075)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G01800 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT2G24190 | Short-chain dehydrogenase/reductase 2 |
Arabidopsis thaliana | AT5G51030 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT3G61220 | (+)-neomenthol dehydrogenase |
Arabidopsis thaliana | AT3G59710 | Rossmann-fold NAD(P)-binding domain-containing protein |
Arabidopsis thaliana | AT5G61830 | NAD(P)-binding Rossmann-fold superfamily protein |
Brugia malayi | Bm1_44405 | oxidoreductase, short chain dehydrogenase/reductase family protein |
Echinococcus granulosus | EgrG_000114400 | carbonyl reductase 1 |
Echinococcus granulosus | EgrG_000114500 | carbonyl reductase 1 |
Echinococcus granulosus | EgrG_000115300 | carbonyl reductase 1 |
Echinococcus granulosus | EgrG_000113500 | carbonyl reductase 1 |
Echinococcus granulosus | EgrG_000115200 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000115200 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000113500 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000114500 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000114300 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000114400 | carbonyl reductase 1 |
Echinococcus multilocularis | EmuJ_000115300 | carbonyl reductase 1 |
Homo sapiens | ENSG00000159231 | carbonyl reductase 3 |
Homo sapiens | ENSG00000159228 | carbonyl reductase 1 |
Leishmania braziliensis | LbrM.34.1150 | short chain dehydrogenase, putative |
Leishmania donovani | LdBPK_351240.1 | short chain dehydrogenase, putative |
Leishmania infantum | LinJ.35.1240 | short chain dehydrogenase, putative |
Leishmania major | LmjF.35.1230 | short chain dehydrogenase, putative |
Leishmania mexicana | LmxM.34.1230 | short chain dehydrogenase, putative |
Mus musculus | ENSMUSG00000051483 | carbonyl reductase 1 |
Mus musculus | ENSMUSG00000022947 | carbonyl reductase 3 |
Mus musculus | 102641578 | carbonyl reductase [NADPH] 1-like |
Mus musculus | 102642943 | carbonyl reductase [NADPH] 1-like |
Neospora caninum | NCLIV_042760 | Dehydrogenases with different specificities, related |
Oryza sativa | 4344332 | Os07g0685800 |
Oryza sativa | 4336497 | Os04g0532400 |
Oryza sativa | 4329932 | Os02g0607700 |
Oryza sativa | 4336495 | Os04g0532100 |
Oryza sativa | 4336494 | Os04g0531900 |
Oryza sativa | 4336492 | Os04g0531700 |
Oryza sativa | 4326939 | Os01g0929500 |
Oryza sativa | 9271852 | Os04g0531750 |
Onchocerca volvulus | OVOC8261 |
|
Schistosoma japonicum | Sjp_0075840 | ko:K00079 carbonyl reductase (NADPH) [EC1.1.1.184], putative |
Schistosoma japonicum | Sjp_0128240 | Carbonyl reductase [NADPH] 1, putative |
Schistosoma mansoni | Smp_033530.1 | carbonyl reductase |
Schistosoma mansoni | Smp_033530.3 | carbonyl reductase |
Schistosoma mansoni | Smp_140270 | carbonyl reductase |
Schistosoma mansoni | Smp_033540 | carbonyl reductase |
Schmidtea mediterranea | mk4.039386.02 | |
Schmidtea mediterranea | mk4.008144.00 | |
Trypanosoma cruzi | TcCLB.508297.50 | short chain dehydrogenase, putative |
Trypanosoma cruzi | TcCLB.508805.80 | short chain dehydrogenase, putative |
Toxoplasma gondii | TGME49_290890 | carbonyl reductase 1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
TGME49_290890 | Toxoplasma gondii | Essentiality uncertain | sidik |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.4
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | carbonyl reductase 3 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Macaca mulatta | Hydroxysteroid 11-beta dehydrogenase 1 | 140 aa | 30.2% | 139 aa | Compounds | References |
Type | Source | Notes |
---|---|---|
soluble recombinant protein | Structural Genomics for Pathogenic Protozoa (SGPP) | Lmaj00462; Recombinant protein: full-length; Source: L major; short chain dehydrogenase, putative; old ID L3377.9 ; |