pI: 8.3843 |
Length (AA): 451 |
MW (Da): 51213 |
Paralog Number:
1
Signal peptide: Y | GPI Anchor: N | Predicted trans-membrane segments: 4
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
350 | 450 | 1eue (A) | 1 | 83 | 28.00 | 0 | 0.91 | 0.43 | -0.53 |
352 | 446 | 1cxy (A) | 6 | 86 | 23.00 | 0 | 0.99 | 0.29 | -0.39 |
29 | 324 | 4ymk (A) | 48 | 342 | 27.00 | 0 | 0.61 | 0.929419 | -0.07 |
355 | 447 | 1aw3 (A) | 6 | 80 | 27.00 | 0 | 1 | 0.351308 | -0.49 |
355 | 447 | 2keo (A) | 25 | 99 | 17.00 | 0 | 0.95 | 0.258308 | -0.61 |
364 | 423 | 3ks0 (A) | 15 | 62 | 46.00 | 0.67 | 0.91 | 0.185738 | 0.42 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Upregulation Percent | Ranking | Stage | Dataset |
---|---|---|---|
Upper 80-100% percentile | amastigotes, metacyclic. | Fernandes MC |
Fernandes MC | Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures. |
Ortholog group members (OG5_126939)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT2G31360 | 16:0delta9 desaturase 2 |
Arabidopsis thaliana | AT1G06350 | delta-9 desaturase-like 4 protein |
Arabidopsis thaliana | AT3G15870 | putative lipid desaturase ADS3.2 |
Arabidopsis thaliana | AT1G06090 | delta-9 desaturase-like 1 protein |
Arabidopsis thaliana | AT1G06120 | delta-9 desaturase-like 3 protein |
Arabidopsis thaliana | AT1G06360 | delta-9 desaturase-like 5 protein |
Arabidopsis thaliana | AT1G06100 | delta-9 desaturase-like 2 protein |
Arabidopsis thaliana | AT3G15850 | palmitoyl-monogalactosyldiacylglycerol delta-7 desaturase |
Arabidopsis thaliana | AT1G06080 | delta-9 acyl-lipid desaturase 1 |
Brugia malayi | Bm1_22105 | acyl-CoA desaturase |
Candida albicans | CaO19.12583 | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase |
Candida albicans | CaO19.5117 | one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase |
Caenorhabditis elegans | CELE_VZK822L.1 | Protein FAT-6, isoform C |
Caenorhabditis elegans | CELE_W06D12.3 | Protein FAT-5 |
Caenorhabditis elegans | CELE_F10D2.9 | Protein FAT-7 |
Dictyostelium discoideum | DDB_G0273105 | cytochrome b5 domain-containing protein |
Dictyostelium discoideum | DDB_G0288801 | cytochrome b5 domain-containing protein |
Dictyostelium discoideum | DDB_G0273837 | delta 9 fatty acid desaturase |
Drosophila melanogaster | Dmel_CG5887 | Desaturase 1 |
Drosophila melanogaster | Dmel_CG7923 | CG7923 gene product from transcript CG7923-RA |
Drosophila melanogaster | Dmel_CG8630 | CG8630 gene product from transcript CG8630-RA |
Drosophila melanogaster | Dmel_CG5925 | Desaturase 2 |
Homo sapiens | ENSG00000145284 | stearoyl-CoA desaturase 5 |
Homo sapiens | ENSG00000099194 | stearoyl-CoA desaturase (delta-9-desaturase) |
Leishmania braziliensis | LbrM.24.2330 | fatty-acid desaturase, putative |
Leishmania braziliensis | LbrM.11.0330 | stearic acid desaturase |
Leishmania donovani | LdBPK_140520.1 | stearic acid desaturase, putative |
Leishmania donovani | LdBPK_242340.1 | fatty-acid desaturase, putative |
Leishmania infantum | LinJ.24.2340 | fatty-acid desaturase, putative |
Leishmania infantum | LinJ.14.0520 | stearic acid desaturase, putative |
Leishmania major | LmjF.24.2250 | fatty-acid desaturase, putative |
Leishmania major | LmjF.14.0510 | stearic acid desaturase, putative |
Leishmania mexicana | LmxM.14.0510 | stearic acid desaturase, putative |
Leishmania mexicana | LmxM.24.2250 | fatty-acid desaturase, putative |
Loa Loa (eye worm) | LOAG_12298 | acyl-CoA desaturase |
Mus musculus | ENSMUSG00000025202 | stearoyl-coenzyme A desaturase 3 |
Mus musculus | ENSMUSG00000025203 | stearoyl-Coenzyme A desaturase 2 |
Mus musculus | 102642893 | acyl-CoA desaturase 1-like |
Mus musculus | ENSMUSG00000037071 | stearoyl-Coenzyme A desaturase 1 |
Mus musculus | 102641835 | acyl-CoA desaturase-like |
Mus musculus | ENSMUSG00000050195 | stearoyl-coenzyme A desaturase 4 |
Neospora caninum | NCLIV_015790 | fatty acyl-CoA desaturase, putative |
Onchocerca volvulus | OVOC7274 |
|
Onchocerca volvulus | OVOC7275 |
|
Plasmodium berghei | PBANKA_1110700 | stearoyl-CoA desaturase, putative |
Plasmodium falciparum | PF3D7_0511200 | stearoyl-CoA desaturase |
Plasmodium knowlesi | PKNH_1022400 | stearoyl-CoA desaturase, putative |
Plasmodium vivax | PVX_080675 | stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative |
Plasmodium yoelii | PY04895 | delta-9 fatty acid desaturase |
Saccharomyces cerevisiae | YGL055W | stearoyl-CoA 9-desaturase |
Trypanosoma brucei gambiense | Tbg972.8.6000 | fatty acid desaturase, putative |
Trypanosoma brucei | Tb927.8.6000 | fatty acid desaturase, putative |
Trypanosoma congolense | TcIL3000_8_5770 | fatty acid desaturase, putative |
Trypanosoma cruzi | TcCLB.511073.10 | fatty acid desaturase, putative |
Trypanosoma cruzi | TcCLB.426435.9 | fatty acid desaturase, putative |
Trypanosoma cruzi | TcCLB.509239.10 | fatty acid desaturase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.8.6000 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.8.6000 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb927.8.6000 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb927.8.6000 | Trypanosoma brucei | no significant loss or gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_W06D12.3 | Caenorhabditis elegans | slow growth | wormbase |
CELE_VZK822L.1 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_VZK822L.1 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_VZK822L.1 | Caenorhabditis elegans | slow growth | wormbase |
CELE_VZK822L.1 | Caenorhabditis elegans | sterile | wormbase |
CELE_F10D2.9 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_F10D2.9 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_F10D2.9 | Caenorhabditis elegans | slow growth | wormbase |
CELE_F10D2.9 | Caenorhabditis elegans | sterile | wormbase |
YGL055W | Saccharomyces cerevisiae | inviable | yeastgenome |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Druggability index (range: 0 to 1): 0.1
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Mus musculus | stearoyl-Coenzyme A desaturase 1 | Compounds | References |
Rattus norvegicus | Acyl-CoA desaturase 1 | Compounds | References |
Homo sapiens | stearoyl-CoA desaturase (delta-9-desaturase) | Compounds | References |
Homo sapiens | stearoyl-CoA desaturase 5 | Compounds | References |