Detailed view for Wbm0146

Basic information

TDR Targets ID: 232719
Wolbachia endosymbiont of Brugia malayi, Kef-type K+ transport system, membrane component
Source Database / ID:  GenBank

pI: 6.2866 | Length (AA): 572 | MW (Da): 61936 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 12

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00999   Sodium/hydrogen exchanger family
PF02254   TrkA-N domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0015299   solute:hydrogen antiporter activity  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0055085   transmembrane transport  
GO:0008152   metabolic process  
GO:0006813   potassium ion transport  
GO:0006812   cation transport  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
63 376 1zcd (A) 68 378 20.00 0.000029 0.38 0.47 0.99
404 540 2g1u (A) 4 140 22.00 0 1 0.53 -0.65
408 516 2aef (A) 116 222 17.00 0 1 0.5 -1.31
409 525 1lss (A) 2 119 28.00 0.00000003 1 0.67 -1.17

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_128017)

Species Accession Gene Product
Arabidopsis thaliana AT5G51710   K(+) efflux antiporter 5
Arabidopsis thaliana AT4G00630   K(+) efflux antiporter 2
Arabidopsis thaliana AT1G01790   K efflux antiporter KEA1
Arabidopsis thaliana AT5G11800   K(+) efflux antiporter 6
Arabidopsis thaliana AT2G19600   K(+) efflux antiporter 4
Cryptosporidium hominis Chro.10250   potassium/proton antiporter
Cryptosporidium parvum cgd1_2190   K+/H+ antiporter of possible bacterial origin, signal peptide
Escherichia coli b3350   potassium:proton antiporter
Escherichia coli b0478   inner membrane putative NAD(P)-binding transporter
Escherichia coli b0047   potassium:proton antiporter
Homo sapiens ENSG00000150403   transmembrane and coiled-coil domains 3
Mycobacterium leprae ML0782   probable conserved integral membrane transport protein
Mus musculus ENSMUSG00000038497   transmembrane and coiled-coil domains 3
Mycobacterium tuberculosis Rv3236c   Probable conserved integral membrane transport protein
Mycobacterium ulcerans MUL_2572   membrane transporter
Oryza sativa 4341306   Os06g0561200
Oryza sativa 4337441   Os04g0682800
Schmidtea mediterranea mk4.112760.00  
Wolbachia endosymbiont of Brugia malayi Wbm0146   Kef-type K+ transport system, membrane component

Essentiality

Wbm0146 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0047 Escherichia coli non-essential goodall
b0478 Escherichia coli non-essential goodall
b3350 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Wbm0146 (Wolbachia endosymbiont of Brugia malayi), Kef-type K+ transport system, membrane component
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