pI: 6.9656 |
Length (AA): 1174 |
MW (Da): 131891 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 11
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 4 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
135 | 1092 | 2o9j (A) | 6 | 979 | 21.00 | 0 | 1 | 0.870714 | 0.83 |
232 | 363 | 2hc8 (A) | 217 | 321 | 31.00 | 0 | 0.99 | 0.219136 | 0.3 |
773 | 885 | 3a1c (A) | 553 | 666 | 25.00 | 0 | 0.96 | 0.407952 | -0.05 |
810 | 856 | 3skx (A) | 555 | 600 | 43.00 | 0.011 | 0.74 | 0.486834 | 0.3 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127048)
Species | Accession | Gene Product |
---|---|---|
Babesia bovis | BBOV_IV008550 | p-type ATPase |
Brugia malayi | Bm1_35140 | E1-E2 ATPase family protein |
Candida albicans | CaO19.9146 | cation translocating P-type ATPase |
Candida albicans | CaO19.1573 | cation translocating P-type ATPase |
Caenorhabditis elegans | CELE_Y59H11AR.2 | Protein CATP-7, isoform C |
Caenorhabditis elegans | CELE_K07E3.7 | Protein CATP-5, isoform A |
Caenorhabditis elegans | CELE_W08D2.5 | Protein CATP-6, isoform B |
Cryptosporidium hominis | Chro.80246 | membrane ATPase |
Cryptosporidium hominis | Chro.30465 | Yor291wp |
Cryptosporidium parvum | cgd3_4140 | P-type ATpase3, 13 transmembrane regions |
Cryptosporidium parvum | cgd8_2090 | cation-transporting ATpase 2 with 8 transmembrane domains |
Dictyostelium discoideum | DDB_G0279183 | P-type ATPase |
Dictyostelium discoideum | DDB_G0284849 | P-type ATPase |
Dictyostelium discoideum | DDB_G0284955 | P-type ATPase |
Drosophila melanogaster | Dmel_CG32000 | CG32000 gene product from transcript CG32000-RH |
Echinococcus granulosus | EgrG_000675400 | cation transporting ATPase 13A3 |
Echinococcus granulosus | EgrG_000572300 | cation transporting atpase worm |
Echinococcus multilocularis | EmuJ_000675400 | cation transporting ATPase 13A3 |
Echinococcus multilocularis | EmuJ_000572300 | cation transporting atpase worm |
Homo sapiens | ENSG00000127249 | ATPase type 13A4 |
Homo sapiens | ENSG00000159363 | ATPase type 13A2 |
Homo sapiens | ENSG00000187527 | ATPase type 13A5 |
Homo sapiens | ENSG00000133657 | ATPase type 13A3 |
Loa Loa (eye worm) | LOAG_08695 | E1-E2 ATPase |
Mus musculus | ENSMUSG00000038094 | ATPase type 13A4 |
Mus musculus | ENSMUSG00000048939 | ATPase type 13A5 |
Mus musculus | ENSMUSG00000022533 | ATPase type 13A3 |
Mus musculus | ENSMUSG00000036622 | ATPase type 13A2 |
Neospora caninum | NCLIV_041450 | cDNA FLJ39191 fis, clone OCBBF2004669, highly similar to Homo sapiens ATPase type 13A4 (ATP13A4), mRNA, related |
Plasmodium berghei | PBANKA_1103600 | cation transporting P-ATPase, putative |
Plasmodium falciparum | PF3D7_0516100 | cation-transporting ATPase 1 |
Plasmodium falciparum | PF3D7_0504000 | cation transporting P-ATPase |
Plasmodium knowlesi | PKNH_1029600 | cation transporting P-ATPase, putative |
Plasmodium vivax | PVX_097770 | P-type ATPase, putative |
Plasmodium yoelii | PY04047 | P-Type ATPase |
Saccharomyces cerevisiae | YOR291W | Ypk9p |
Schistosoma japonicum | Sjp_0052580 | Probable cation-transporting ATPase K07E3.7, putative |
Schistosoma japonicum | Sjp_0203040 | expressed protein |
Schistosoma japonicum | Sjp_0056850 | Probable cation-transporting ATPase K07E3.7, putative |
Schistosoma japonicum | Sjp_0037010 | ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative |
Schistosoma japonicum | Sjp_0037020 | Probable cation-transporting ATPase W08D2.5, putative |
Schistosoma japonicum | Sjp_0017260 | Probable cation-transporting ATPase W08D2.5, putative |
Schistosoma japonicum | Sjp_0316170 | expressed protein |
Schistosoma japonicum | Sjp_0056910 | Conserved hypothetical protein |
Schistosoma mansoni | Smp_175360.2 | cation-transporting atpase worm |
Schistosoma mansoni | Smp_172750 | type V p-type atpase isoform |
Schistosoma mansoni | Smp_128460 | type V p-type atpase isoform |
Schistosoma mansoni | Smp_175370 | type V p-type atpase isoform |
Schistosoma mansoni | Smp_175360.1 | cation-transporting atpase worm |
Schmidtea mediterranea | mk4.005149.00 | |
Schmidtea mediterranea | mk4.002291.03 | Probable cation-transporting ATPase 13A2 |
Schmidtea mediterranea | mk4.002291.02 | |
Schmidtea mediterranea | mk4.002291.01 | |
Schmidtea mediterranea | mk4.009667.03 | |
Schmidtea mediterranea | mk4.009933.00 | |
Theileria parva | TP01_0922 | P-type ATPase, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
PBANKA_1103600 | Plasmodium berghei | Essential | plasmo |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 1043 aa | 23.3% | 889 aa | Compounds | References |
Rattus norvegicus | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 994 aa | 23.3% | 890 aa | Compounds | References |