Detailed view for Bm1_07670

Basic information

TDR Targets ID: 233427
Brugia malayi, cytochrome C-type heme lyase
Source Database / ID:  GenBank

pI: 8.458 | Length (AA): 277 | MW (Da): 31976 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF01265   Cytochrome c/c1 heme lyase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005739   mitochondrion  
GO:0004408   holocytochrome-c synthase activity  

Metabolic Pathways

Porphyrin and chlorophyll metabolism (KEGG)

Structural information

Modbase 3D models:

There is 1 model calculated for this protein. More info on this model, including the model itself is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
183 215 4k6l (F) 76 108 36.00 0.89 0.06 0.340534 1.38

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127581)

Species Accession Gene Product
Babesia bovis BBOV_IV008890   cytochrome c/c1 heme lyase, putative
Babesia bovis BBOV_III011500   cytochrome c/c1 heme lyase, putative
Brugia malayi Bm1_07670   cytochrome C-type heme lyase
Candida albicans CaO19.1957   cytochrome c heme lyase similar to S. cerevisiae CYC3 (YAL039C)
Candida albicans CaO19.12047   cytochrome c1 heme lyase
Candida albicans CaO19.4578   cytochrome c1 heme lyase
Caenorhabditis elegans CELE_T06D8.6   Protein CCHL-1
Dictyostelium discoideum DDB_G0275895   cytochrome c heme-lyase
Drosophila melanogaster Dmel_CG6022   Cytochrome c heme lyase
Echinococcus granulosus EgrG_000965700   cytochrome c type heme lyase
Echinococcus multilocularis EmuJ_000965700   cytochrome c type heme lyase
Homo sapiens ENSG00000004961   holocytochrome c synthase
Loa Loa (eye worm) LOAG_08710   cytochrome C-type heme lyase
Mus musculus ENSMUSG00000031352   holocytochrome c synthetase
Neospora caninum NCLIV_000340   hypothetical protein
Neospora caninum NCLIV_057230   cytochrome c heme lyase, putative
Plasmodium berghei PBANKA_1439500   cytochrome c heme lyase
Plasmodium berghei PBANKA_0602600   cytochrome c1 heme lyase
Plasmodium falciparum PF3D7_1224600   cytochrome c heme lyase, putative
Plasmodium falciparum PF3D7_1203600   cytochrome c1 heme lyase, putative
Plasmodium knowlesi PKNH_1443900   cytochrome c heme lyase, putative
Plasmodium knowlesi PKNH_1303400   cytochrome c1 heme lyase, putative
Plasmodium vivax PVX_084225   cytochrome c1 heme lyase, putative
Plasmodium vivax PVX_123860   cytochrome c heme lyase, putative
Plasmodium yoelii PY05914   cytochrome c1 heme lyase
Saccharomyces cerevisiae YKL087C   cytochrome c1 heme lyase CYT2
Saccharomyces cerevisiae YAL039C   holocytochrome c synthase CYC3
Schistosoma japonicum Sjp_0011050   ko:K01764 cytochrome c heme-lyase [EC4.4.1.17], putative
Schistosoma mansoni Smp_022320.1   cytochrome C1 heme lyase
Schistosoma mansoni Smp_022320.2   cytochrome C1 heme lyase
Schmidtea mediterranea mk4.003317.04  
Schmidtea mediterranea mk4.006193.00   Probable cytochrome c-type heme lyase
Schmidtea mediterranea mk4.004164.00  
Schmidtea mediterranea mk4.011512.02  
Toxoplasma gondii TGME49_314042   cytochrome c1 heme lyase, putative
Toxoplasma gondii TGME49_293390   cytochrome C-type heme lyase, putative
Theileria parva TP02_0784   cytochrome c heme lyase, putative
Theileria parva TP01_0886   cytochrome c1 heme lyase, putative

Essentiality

Bm1_07670 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_T06D8.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_T06D8.6 Caenorhabditis elegans larval arrest wormbase
CELE_T06D8.6 Caenorhabditis elegans slow growth wormbase
PBANKA_1439500 Plasmodium berghei Essential plasmo
TGME49_293390 Toxoplasma gondii Probably essential sidik
TGME49_314042 Toxoplasma gondii Probably essential sidik
TGME49_293390 Toxoplasma gondii Essentiality uncertain sidik
TGME49_314042 Toxoplasma gondii Essentiality uncertain sidik
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_07670 (Brugia malayi), cytochrome C-type heme lyase
Title for this comment
Comment