Detailed view for Bm1_45670

Basic information

TDR Targets ID: 233756
Brugia malayi, WH2 motif family protein

Source Database / ID:  GenBank

pI: 9.6383 | Length (AA): 582 | MW (Da): 64762 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF02205   WH2 motif
PF14943   Mitochondrial ribosome subunit S26

Gene Ontology

Mouse over links to read term descriptions.
GO:0005763   mitochondrial small ribosomal subunit  
GO:0003779   actin binding  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
2 86 3add (A) 159 240 32.00 0.2 0.36 0.440748 -0.53
3 93 5hmo (A) 817 925 32.00 0.16 0.06 0.290057 -0.32
4 76 5lpn (B) 972 1055 14.00 0 0.01 0.41083 -1.96

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein


No expression data available for this gene


Ortholog group members (OG5_130332)

Species Accession Gene Product
Brugia malayi Bm1_45670   WH2 motif family protein
Candida albicans CaO19.9736   similar to S. cerevisiae VRP1 (YLR337C) proline-rich protein verprolin
Candida albicans CaO19.2190   similar to S. cerevisiae VRP1 (YLR337C) proline-rich protein verprolin
Caenorhabditis elegans CELE_R144.4   Protein WIP-1, isoform B
Dictyostelium discoideum DDB_G0270430   WH2 domain-containing protein
Dictyostelium discoideum DDB_G0269708   SH3 domain-containing protein
Drosophila melanogaster Dmel_CG13503   Verprolin 1
Homo sapiens ENSG00000115935   WAS/WASL interacting protein family, member 1
Loa Loa (eye worm) LOAG_01040   hypothetical protein
Mus musculus ENSMUSG00000075284   WAS/WASL interacting protein family, member 1
Onchocerca volvulus OVOC13470  
Saccharomyces cerevisiae YLR337C   Vrp1p
Schistosoma japonicum Sjp_0092690   IPR003124,Actin-binding WH2,domain-containing
Schistosoma japonicum Sjp_0099970   hypothetical protein
Schistosoma mansoni Smp_175620   rhoptry protein
Schistosoma mansoni Smp_189790   hypothetical protein


Bm1_45670 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_R144.4 Caenorhabditis elegans embryonic lethal wormbase
Show/Hide essentiality data references
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • wormbase C. elegans RNAi experiments WormBase web site,, release WS170
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model
No druggable targets predicted through repurposing network model


Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Bm1_45670 (Brugia malayi), WH2 motif family protein
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